Therapeutical Effect of Extracts of Terminalia chebula In Inhibiting Human Pathogens and Free Radicals

Abstract

Abstract-In recent years, multiple drug resistance has been developed due to indiscriminate use of existing antimicrobial drugs in the treatment of infectious diseases. Conventional antibiotics are strong medicines, which if not used in precise way may cause harmful effects. The major thrust is to establish alternative antimicrobial agent in order to treat microbial infections with less or no toxic effect to body and less negligible side effects. The herbal medicines have shown potential to overcome the limitation associated with conventional drugs. However, the appropriate choice of source for herbal medicine is also very important. Terminalia chebula possesses potential pharmaceutical activities and used in several Ayurvedic formulations. The study of solvent-free organic (ethylacetate, acetone, methanol of increasing polarity) and aqueous extracts of the fruits of T. chebula, showed the potential to reduce growth of microorganisms, minimizing the risk of infection, while optimizing the conditions to encourage healing. In our study we found, methanol extract as a potential bactericidal and potent antioxidant while aqueous extract showed the least potential as an antimicrobial agent, though a moderate antioxidant. The finding may provide scientific rationale for the use of crude extract of the plant as a new drug compound as potential antioxidant and antimicrobial agent.

Effect of Extracts of Terminalia chebula on Proliferation of Keratinocytes and Fibroblasts Cells: An Alternative Approach for Wound Healing

“…The principle compound known in T. chebula extracts is gallic acid which is an active blocker of T-lymphocyte mediated cytotoxicity which in turn blocks the major immunocascade resulting in enhanced cellular functionality. Besides this cytoprotective effect of T. chebula extract on inhibitory effect and oxidative stress on cellular aging is well documented [ 13 , 29 – 31 ]. However, this is first time different extracts are tested in the in vitro system together to identify the optimal concentration that can influence metabolic activity of cells.…”

In Vitro Evaluation of Bilvadi Agada (Herbo-Mineral Compound) for Anti-Microbial and Anti-Fungal Activity

“…10 Similarly O. sanctum displayed marked antibacterial efficacy against E. coli, S. aureus and B. subtilis. 11,12 Likewise Pongamia pinnata [13][14][15][16] Valeriana wallichii [17][18][19][20] Cedrus deodara 21,22 Terminalia chebula as anti-microbial [23][24][25][26][27][28][29][30][31][32][33] and anti-fungal [34][35][36][37] Terminalia bellirica [38][39][40] Emblica officinalis [41][42][43][44][45] Zingiber officinale [46][47][48][49] Piper nigrum [50][51][52] Piper longum [53][54][55] Curcuma longa [56][57][58][59]…”