Effect of crude extract and its semi purified constituents from guaraná seeds [Paullinia cupana var. sorbilis (Mart.) lucke] on cognitive performance in Morris water maze in rats

Abstract

The effect of crude lyophilized extract (EBPC) and the semi-purified constituents (EPA and EPB) of

Spectrophotometric determination of tannins and caffeine in preparations from Paullinia cupana var. sorbilis

“…sorbilis (guaraná), a plant native to the Amazon region, are popularly used as a brain-function stimulant, aphrodisiac, tonic, diuretic, and sedative, among others (Henman, 1982;Duke, 1985). Reports have shown that the extracts from its powdered seeds show antioxidant (Ushirobira, 2003;Mattei et al, 1998), antiplatelet (Bydlowski et al, 1988), antifatigue (Espínola et al, 1997) and antidepressant activities (Otobone et al, 2005). The analyses of P. cupana demonstrated that the caffeine (Henman, 1982;Corrêa, 1984;Ushirobira, 2003;Bempong et al, 1993;Andrade, 1996) and condensed tannins such as flavan-3-ol and procyanidins (Ushirobira, 2003;Andrade, 1996;Carlson et al, 1998) were the main constituents of the extracts from its seeds.…”

Effect of lyophilized extracts from guaraná seeds [Paullinia cupana var. sorbilis (Mart.) Ducke] on behavioral profiles in rats

“…Whereas EBPC and EPA extracts reduced the latency of escape, showing a nootropic-like effect in normal rats and in scopolamine-induced-amnesia rats, caffeine altered the escape latency only in scopolamine-induced-amnesia rats in the emerged platform in the Morris water maze (Otobone et al, 2005). In popular medicine, caffeine is generally considered to be a psychostimulant and a fatigue reducer (Benowitz, 1990).…”

Paullinia cupana Kunth (Sapindaceae): A review of its ethnopharmacology, phytochemistry and pharmacology

“…Low toxicity Vermaak (2011), Mello (2010a, , Santa Maria (1998), Mattei (1998), andFonseca (1994) Antioxidant activity Bittencourt (2013), Portella (2013), Dalonso (2012), Majhenic (2007), Mendes and Carlini (2007), Yamaguti-Sasaki (2007), Basile (2005), and Mattei (1998) Antibacterial and antifungal activities Basile (2013Basile ( , 2005, Majhenic (2007), Yamaguti-Sasaki (2007) Antidepressive, anxiolytic and antiamnesic effects Roncon (2011), Shahwar (2010, Antonelli (2007), Majhenic (2007), Otobone (2005Otobone ( , 2007, , Basile (2005), Espinola (1997), and Mattei (1998) Chemoprophylactic in carcinogenesis and antigenotoxic activity Fukumasu (2011Fukumasu ( , 2008Fukumasu ( , 2006a, Oliveira ( , 2011, Leite (2011);Cragg (2006), and Espinola (1997) Inhibition of platelet aggregation Bydlowski (1991Bydlowski ( , 1988) Protection against gastric lesions Campos (2003) Lower risk of obesity, hypertension and metabolic syndrome Krewer (2011) Antifatigue effects Campos (2011) The seeds of Guaraná also contain acylglycerols and cyanolipids (Figure 3), an unusual class of plant lipids restricted to only a few families, such as Sapindaceae, Hippocastanacaeae and Boraginaceae (Moller and Seigler, 1999). The study of the oil from P. cupana Kunth var.…”

“…The extracts of P. cupana show antidepressive, anxiolytic and anti-amnesic effects (Roncon et al, 2011;Shahwar et al, 2010;Antonelli et al, 2007;Otobone et al, 2007Otobone et al, , 2005Ushirobira et al, 2007;Basile et al, 2005;Majhenic et al, 2007;Espinola et al, 1997;Mattei et al, 1998). Different from caffeine, its antidepressant action, particularly after long-term treatment, is comparable to that of the tricyclic antidepressant imipramine (Tofranil), and it has a beneficial effect on cognition without altering locomotor activity Otobone et al, 2005Otobone et al, , 2007Kennedy et al, 2004;Roncon et al, 2011;Carlini, 2003).…”

“…Different from caffeine, its antidepressant action, particularly after long-term treatment, is comparable to that of the tricyclic antidepressant imipramine (Tofranil), and it has a beneficial effect on cognition without altering locomotor activity Otobone et al, 2005Otobone et al, , 2007Kennedy et al, 2004;Roncon et al, 2011;Carlini, 2003).…”