Paullinia cupana Kunth (Sapindaceae): A review of its ethnopharmacology, phytochemistry and pharmacology

Hamerski, Lidilhone; Somner, Genise Vieira; Tamaio, Neusa

doi:10.5897/jmpr2013.5067

Cited by 26 publications

(6 citation statements)

References 68 publications

(102 reference statements)

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“…In agreement with previously reported results, guarana showed a high antioxidant activity in vitro [41][42][43][44][45][46]. It is not surprising that the radical scavenging capacity of the extract was so high, given the known hydrogen and electron-donating ability of polyphenols [47].…”

Section: Discussionsupporting

confidence: 92%

Alterations in Bacterial Metabolism Contribute to the Lifespan Extension Exerted by Guarana in Caenorhabditis elegans

et al. 2022

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Guarana (Paullinia cupana) is a widely consumed nutraceutical with various health benefits supported by scientific evidence. However, its indirect health impacts through the gut microbiota have not been studied. Caenorhabditis elegans is a useful model to study both the direct and indirect effects of nutraceuticals, as the intimate association of the worm with the metabolites produced by Escherichia coli is a prototypic simplified model of our gut microbiota. We prepared an ethanoic extract of guarana seeds and assessed its antioxidant capacity in vitro, with a 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, and in vivo, utilizing C. elegans. Additionally, we studied the impact of this extract on C. elegans lifespan, utilizing both viable and non-viable E. coli, and assessed the impact of guarana on E. coli folate production. The extract showed high antioxidant capacity, and it extended worm lifespan. However, the antioxidant and life-extending effects did not correlate in terms of the extract concentration. The extract-induced life extension was also less significant when utilizing dead E. coli, which may indicate that the effects of guarana on the worms work partly through modifications on E. coli metabolism. Following this observation, guarana was found to decrease E. coli folate production, revealing one possible route for its beneficial effects.

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Section: Discussionsupporting

confidence: 92%

Alterations in Bacterial Metabolism Contribute to the Lifespan Extension Exerted by Guarana in Caenorhabditis elegans

et al. 2022

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“…Guarana seeds in addition to caffeine, contains a number of other possible stimulants such as flavonoids, or other potentially psychoactive components, including saponins and tannins, which could enhance cognitive function (33,34).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Caffeine and Pre-Workout Multi-Ingredient Performance Supplement on Reactive Agility and Countermovement Jump Height

Kaczka

Kubicka

Batra

et al. 2021

Preprint

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BackgroundThe purpose of this investigation was to examine the acute effects of a commercially available multi-ingredient performance supplement (MIPS) in comparison to caffeine, on reactive agility and jump height, in recreationally-trained handball male players. MethodsThe study followed a randomized double-blind, crossover design. Twenty-four individuals were treated with placebo, caffeine or multi-ingredient performance supplement (MIPS). Dosage of caffeine in caffeine supplement and MIPS contain the same amounts of caffeine for each subject (5 mg/kg) . All subjects attended a familiarization session 1 week before testing. Participants underwent reactive agility test (Y-test: 1-1-2 test) on three separate days with 72 h apart between test days. Just after accomplishing of each repetition of reactive agility tests participants were asked to perform countermovement jump (CMJ; 2 repetitions separated by one minute break) to establish the average height of jump, that is directly related to lower body power. To assess the significance of differences between the groups studied, Friedmann ANOVA test was used, the chi-square value (χ2) calculated and the p value of statistical significance estimated. ResultsThe research indicated significant inter-group differences in 1-1-2 agility test (p=0.04). The time was significantly shorter for MIPS supplement group in comparison to placebo (-3.4%; p=0.02) and to caffeine (-2.8%; p=0.004) group. Significant improvements (p<0.01) were observed in jump height for MIPS supplement group in comparison to placebo (+5.2%; p=0.001) and caffeine (+5.1%; p=0.001) groups, but not in caffeine to placebo comparison (p=0.84). ConclusionsThe results of these study may contribute to the assessment of the usefulness of multi-ingredient performance type supplementation in comparison to the ingestion of identical amounts of caffeine only in enhancing reactive agility and jump performance.

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“…Aparna Sudhan 1 , Prabhu K 2 , Deepalakkshmi Balakrishnan 3 , Sumathi Jones 4* , Mudiganthi Ramakrishna Rao 5 , Kavimani M 6 memory and immunity (27). Cynodon dactylon is a common herb, known as Durva grass in Ayurveda, is used traditionally to treat various ailments such as anasarca, cancer, convulsions, cough, cramps, dropsy, dysentery, epilepsy, headache, internal bleeding, high blood pressure, hysteria, measles, rubella, snakebite, sores, stones, tumours, UTI disorders, warts, and wounds (28).…”

Section: Arukaladi Tailammentioning

confidence: 99%

The GCMS, antioxidant, and anti-inflammatory activity of the Ayurveda oil, Arukaladi tailam

Sudhan,

Balakrishnan

et al. 2024

IJAM

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Ayurvedic tailams have a long history of use and efficacy. They have been used for centuries, with many individuals reporting positive results in managing and improving their health. Ayurvedic tailams typically have fewer side effects compared to synthetic medications, making them a preferred choice for individuals seeking natural remedies and can be applied both externally (for massage) and, in some cases, internally (for specific therapies). This versatility allows for a wide range of applications and health benefits.The current study focuses on the GC MS analysis of Arukaladi tailam, an oil composition used in Ayurveda to treat jaundice when administered topically. Before being subjected to the GC MS analysis, the product was appropriately prepared after being purchased from a reputable Ayurvedic dealer in Chennai, India. The IC50 value of the DPPH assay was found to be 744.7391μl/ml and FRAP reveals that the tailam had good reducing power. Further the anti-inflammatory of the tailam exhibited 14.2% of haemolysis at 1000μl/ml and inhibited protein denaturation by 63.74% with an IC50 value of 789.4013 µl/ml. The presence of biomolecules as shown in the GC MS profile are 2-Fluoro-6-trifluoromethylbenzoic acid, 2- tetradecyl ester, Tridecanol, 2-ethyl-2-methyl-, etc. These chemicals could help the medication work better to treat jaundice.

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Paullinia cupana Kunth (Sapindaceae): A review of its ethnopharmacology, phytochemistry and pharmacology

Cited by 26 publications

References 68 publications

Alterations in Bacterial Metabolism Contribute to the Lifespan Extension Exerted by Guarana in Caenorhabditis elegans

Alterations in Bacterial Metabolism Contribute to the Lifespan Extension Exerted by Guarana in Caenorhabditis elegans

The Effects of Caffeine and Pre-Workout Multi-Ingredient Performance Supplement on Reactive Agility and Countermovement Jump Height

The GCMS, antioxidant, and anti-inflammatory activity of the Ayurveda oil, Arukaladi tailam

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