Absence of antidiabetic and hypolipidemic effect of Gymnema sylvestre in non-diabetic and alloxan-diabetic rats

Abstract

In this study we investigated the antidiabetic and hypolipidemic potential of dried powdered leaves of Gymnema sylvestre (GS). The acute effect of GS administered by oral gavage on glucose blood level of and lipids in nondiabetic and alloxan-diabetic rats were investigated in the following conditions: a) after a balanced meal; b) after the ingestion of 1000 mg/kg amylose or 1000 mg/kg glucose; c) after the ingestion of a mixture of 12 mL/kg soybean oil + 1% cholesterol (SOC). In addition, the effect of the treatment with GS during two (sub-acute)

Effect of naringerin on biochemical parameters in the streptozotocin-induced diabetic rats

“…Streptozotocin was recognised as a toxic agent for B-cells of the islets of Langerhans (Agarwal 1980), and has since then been widely used for the induction of diabetes mellitus with concomitant insulin deficiency (Bolzán and Bianchi, 2002). Changes in concentrations of plasma lipids including cholesterol and lipoprotein are complication frequently observed in patients with diabets mellitus and certainly contributes to the development of coronary heart disease in these patients (Soyers et al, 2001;Galletto et al, 2004;Wold et al, 2005). A high dietary content of fresh fruits and vegetables has been positively associated with a reduced incidence of coronary heart disease (CHD) by several epidemiological studies (Spignoli, 2000).…”

Hypoglycemic effect of the hydroalcoholic extract of leaves of Averrhoa carambola L. (Oxalidaceae)

“…Since our fi rst study demonstrating antidiabetic properties of Stevia rebaudiana leaves (Curi et al, 1986), we have been investigating the hypotensive , antiobesity (Siqueira et al, 2006), hypolipidemic (Silva et al, 2004) and antidiabetic (Galletto et al, 2004) properties of the Brazilian plants.…”

Investigation of the Acute Effects of Dry Extract of Glycine Max on Postprandial Glycemia in Rats

“…However, there is absence of in vivo studies demonstrating antihyperglycemic properties of these compounds. Furthermore, as we previously demonstrated [23][24][25] nondiabetic rats represents a suitable pre-clinical model to investigate the impact of oral carbohydrates on post prandial glycemia. Thus, by using this rat model we investigate if dried extracts of GM could reduce the elevation of glycemia promoted by oral ingestion of soluble starch.…”