Metabolismo do ferro: uma revisão sobre os principais mecanismos envolvidos em sua homeostase

Grotto, Helena Zerlotti Wolf

doi:10.1590/s1516-84842008000500012

Cited by 56 publications

(60 citation statements)

References 36 publications

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“…23 Anemia in patients with neoplasm can be explained by several factors such as the increase in the cytokine interferon gamma, tumor necrosis factor alpha, interleukin (IL) IL1, IL6. 24 As expected, anemia was a frequent finding in the groups studied, with an average final Hb (last collection) of 9.35 g/dL in SG and 8.3 g/dL in DG, which is a statistically significant difference (p=0.0241).…”

Section: Discussionsupporting

confidence: 71%

Cervical cancer: Renal complications and survival after percutaneous nephrostomy

Souza

Kirsztajn

et al. 2016

Rev. Assoc. Med. Bras.

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Introduction:Obstructive nephropathy is a frequent complication in the course of advanced cervical cancer (CC), and ultrasonography-guided percutaneous nephrostomy (PCN) is a well established technique for fast ureteral desobstruction. Objective: To identify possible factors related to the survival and quality of life of patients with advanced CC presenting acute urinary obstructive complications that after desobstruction by PCN recovered urinary flux and renal function. Method: This is an analytical, descriptive, cross-sectional study that included 45 patients with CC who underwent PCN and were divided into 2 groups: "death" (DG) and "survival" (SG), in a public hospital that is reference for oncologic diseases in Northern Brazil. Results: The mean serum creatinine of the patients preceding PCN was >10 mg/ dL, and after PCN <2 mg/dL. The cutoffs of 8.7 g/dL for Hb (p=0.0241) and 27% for Ht (p=0.0065) indicated the values that better discriminate the outcomes of the groups. The presence of low blood pressure was statistically correlated (p=0.0037) to the outcome "death". Changes in glomerular filtration rate (already reduced in all cases) were not associated to the levels of Hb/Ht or to the outcome "death" during the nephrological follow-up. Conclusion: PCN was responsible for the recovery of renal function in 61.7% of the patients, leading to interruption of renal replacement therapy (RRT) in all of those patients. Hb levels >8.7g/dL and Ht >27% were associated to longer survival, and the presence of low blood pressure during follow-up was associated with progression to death.

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Section: Discussionsupporting

confidence: 71%

Cervical cancer: Renal complications and survival after percutaneous nephrostomy

Souza

Kirsztajn

et al. 2016

Rev. Assoc. Med. Bras.

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“…Studies that related hepcidin to hemochromatosis, thalassemia, and anemia of chronic disease and inflammation were excluded, resulting in 36 studies: 35 articles published in international journals and one article in a Brazilian journal 20 .…”

Section: Methodsmentioning

confidence: 99%

“…Iron homeostasis is regulated by two main mechanisms: an intracellular mechanism, dependent on the amount of iron available for the cell, and a systemic mechanism, in which hepcidin plays a crucial role 20,28 .…”

Section: Hepcidin Expression Related To Iron Deficiency Anemiamentioning

confidence: 99%

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A hepcidina como parâmetro bioquímico na avaliação da anemia por deficiência de ferro

Lemos¹,

Ismael²,

Boato³

et al. 2010

Rev. Assoc. Med. Bras.

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“…[12][13][14] The absorption of iron occurs primarily in the bowel and, according to Grotto (2008), approximately 1 to 2 mg of iron is absorbed per day via the duodenum. Iron is considered to be essential, as it is required for several critical functions in the human body.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of in vitro Bioaccessibility of Copper, Iron and Manganese in Amazonian Fruits

Alves¹,

Nunes²,

Dantas³

2017

Rev. Virtual Quim.

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Abstract:The bioaccessibility of Cu, Fe and Mn in Amazonian fruits (açaí, white açaí, bacuri and tucumã) was evaluated in this study using in vitro methods. Flame atomic absorption spectrometry (FAAS) was used for total metal quantification, and graphite furnace atomic absorption spectrometry (GFAAS) was used to quantify the metals in the simulated gastric and gastrointestinal digestions. The Cu concentration in the fruits tested varied between 8.59 and 14.99 mg/kg. For Fe, the concentration in the samples ranged from 35.88 to 60.45 mg/kg. The lowest and highest concentrations of Mn were found in bacuri (5.01 mg/kg) and white açaí (709.93 mg/kg), respectively. In the açaí, white açaí and tucumã samples, the bioaccessible percentage of Cu was higher than the human can absorb. The available Fe value determined in the gastric simulation was similar to that observed in the gastrointestinal simulation, varying from 42.95 to 56.22%. The bioaccessible Mn fraction varied between 28.72 and 68.78% in the gastric simulation and between 26.81 and 64.85% in the gastrointestinal simulation. This study contributes to our knowledge of the actual amount of Cu, Fe and Mn absorbed by ingestion of the studied fruits.Keywords: Bioaccessibility; Amazonian fruits; inorganic elements; FAAS, GFAAS. ResumoA bioacessibilidade de Cu, Fe e Mn em frutas da Amazônia (açaí, açaí branco, bacuri e tucumã) foram avaliadas neste estudo utilizando métodos in vitro. A espectrometria de absorção atômica com chama (FAAS) foi utilizada para a quantificação total de metal e a espectrometria de absorção atômica em forno de grafite (GF AAS) foi utilizada para quantificar os metais nas digestões gástricas e gastrointestinais simuladas. A concentração de Cu nos frutos testados variou entre 8,59-14,99 mg/kg. Para Fe, a concentração nas amostras variou de 35,88-60,45 mg/kg. As menores e maiores concentrações de Mn foram encontradas nos bacuri (5,01 mg/kg) e açaí branco (709,93 mg/kg), respectivamente. Nas amostras de açaí, açaí branco e tucumã, o percentual bioaccessível de Cu foi maior do que o ser humano pode absorver. O valor de Fe disponível na simulação gástrica foi semelhante ao observado na simulação gastrointestinal, variando de 42,95 a 56,22%. A fração Mn bioacessível variou entre 28,72-68,78% na simulação gástrica e 26,81-64,85% na simulação gastrointestinal. Este estudo contribui para o conhecimento da quantidade real de Cu, Fe e Mn absorvidos pela ingestão dos frutos estudados.

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Metabolismo do ferro: uma revisão sobre os principais mecanismos envolvidos em sua homeostase

Cited by 56 publications

References 36 publications

Cervical cancer: Renal complications and survival after percutaneous nephrostomy

Cervical cancer: Renal complications and survival after percutaneous nephrostomy

A hepcidina como parâmetro bioquímico na avaliação da anemia por deficiência de ferro

Evaluation of in vitro Bioaccessibility of Copper, Iron and Manganese in Amazonian Fruits

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