Importância da presença de granulações tóxicas para o diagnóstico hematológico de septicemia

Abstract

Importância da presença de granulações tóxicas para o diagnóstico hematológico de septicemia The investigation of the presence of toxic granulation for septicemia hematologic diagnostic

Pathological profiles of systemic infections by Panton‐Valentine leukocidin‐positive, methicillin‐resistant Staphylococcus aureus strains in a murine model

“…In all animal groups, the presence of reactive lymphocytes after 24 h, and monocytes in 48 h, is suggestive of an intense immunological response to the pathogen. Both cells may cause cellular and tissue lesions, frequently observed during multiple organ failure associated with sepsis (Hokama and Machado 1997;Salgado et al 2007).…”

“…The presence of activated neutrophils is suggestive of disseminated destruction that occurs in severe inflammatory processes during the bacterial infections (Salgado et al 2007). The neutrophils observed in both BC01 PVL + and BC02 PVL + groups presented diverse aspects.…”

“…Bands were previously related to pro-inflammatory cytokines mediated bone marrow response (Hokama and Machado 1997). In some instances, granulocytes may present toxic granules, formed during endocytosis of bacterial toxic compounds and other specific inductors, and are associated with the damage of tissues (Salgado et al 2007). In all of the animal groups infected with PVL-positive strains, the neutrophils presented micronuclei and may represent a pattern of neutrophil damage associated with PVL-positive strains (Agostini 1993;Boyle-Vavra and Daum 2007;Ferraz et al 2016).…”