Crescimento e desenvolvimento nas doenças falciformes

Veríssimo, Monica P. A.

doi:10.1590/s1516-84842007000300015

Cited by 8 publications

(11 citation statements)

References 23 publications

(35 reference statements)

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“…The anthropometric abnormalities of both male and female adult SCA patients have been well known for a long time. For example, menarche in SCA women is two to three years later than in non-SCA individuals with weight being a predictive factor ( 4) .…”

Section: Introductionmentioning

confidence: 99%

Sexuality and sickle cell anemia

Côbo¹,

Chapadeiro²,

Ribeiro³

et al. 2013

Revista Brasileira De Hematologia E Hemoterapia

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Background Sickle cell disease, the most common hereditary blood disease in the world, is the result of an atypical hemoglobin called S (Hb S) which, when homozygous (Hb SS) is the cause of sickle cell anemia. Changes of puberty, correlated with a delayed growth spurt, begin late in both male and female sickle cell anemia individuals with repercussions on sexuality and reproduction. The objectives of this exploratory and descriptive study were to characterize the development of sexuality in adults with sickle cell anemia by investigating the patient's perception of their sex life, as well as the information they had and needed on this subject. Methods Twenty male and female sickle cell anemia patients treated at the Hemocentro Regional de Uberaba (UFTM) with ages between 19 and 47 years old were enrolled. A socioeconomic questionnaire and a semi-structured interview on sexuality, reproduction and genetic counseling were applied. Results This study shows that the sickle cell anemia patients lacked information on sexuality especially about the risks of pregnancy and the possible inheritance of the disease by their children. Moreover, the sexual life of the patients was impaired due to pain as well as discrimination and negative feelings experienced in close relationships. Conclusion The health care of sickle cell anemia patients should take into account not only the clinical aspects of the disease, but also psychosocial aspects by providing counseling on sexuality, reproduction and genetics, in order to give this population the possibility of a better quality of life.

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Section: Introductionmentioning

confidence: 99%

Sexuality and sickle cell anemia

Côbo¹,

Chapadeiro²,

Ribeiro³

et al. 2013

Revista Brasileira De Hematologia E Hemoterapia

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“…The pubertal delay associated with bone age delay, followed by abnormal delay of epiphyseal fusion during puberty, allows the growth of long bones for a variable period of time in early adulthood, thereby explaining the paradoxical relationship between delayed prepubertal growth and standard height in adulthood 19 . IGF-1 levels in children and adolescents with sickle-cell anaemia at Te1 were significantly lower than those of the control group, which matches the pubertal delay presented by the group and is in accordance with previous findings 20 .…”

Section: Discussionmentioning

confidence: 99%

Growth and puberty in a prospective cohort of patients with sickle-cell anaemia: an assessment over ten years abstract

Gomes

Melo

et al. 2017

J. Hum. Growth Dev.

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Suggested citation: Gomes ICP, Melo HI, Melo SIA, Menezes NV, Dantas TVP, Cipolotti R. Growth and puberty in a prospective cohort of patients with sickle-cell anaemia: an assessment over ten years. J Hum Growth Dev. 2017; 7(1): 91-98 AbstractIntroduction: Hereditary haemoglobinopathies are the most common group of monogenic hereditary diseases in the world. Erythrocytes in sickle form, cellular expression of polymerization of deoxygenated HbS, cause intermittent vascular obstruction, leading to tissue ischaemia and consequent chronic damage in organs and endocrine glands.

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“…4 Consequently, reproductive issues will take a higher priority in SCD, such as delay of pubertal development, delay of first pregnancy, complications in pregnancy and postpartum, and the choice of contraceptive method. [4][5][6][7][8] Although several studies have demonstrated the influence of the HbSS genotype on some sexual and reproductive issues, there are limited data regarding other SCD genotypes. 5,7,9 The objective of this study was to describe the reproductive variables in different SCD genotypes and the influence of the contraceptive method on acute painful episodes among women with the HbSS genotype.…”

Section: Introductionmentioning

confidence: 99%

Profile of Reproductive Issues Associated with Different Sickle Cell Disease Genotypes

Carvalho

Souza

Ferreira

et al. 2017

Rev Bras Ginecol Obstet

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To describe the reproductive variables associated with different sickle cell disease (SCD) genotypes and the influence of contraceptive methods on acute painful episodes among the women with the homozygous hemoglobin S (HbSS) genotype. A cross-sectional study was conducted between September of 2015 and April of 2016 on 158 women afflicted with SCD admitted to a hematology center in the Northeast of Brazil. The reproduction-associated variables of different SCD genotypes were assessed using the analysis of variance (ANOVA) test to compare means, and the Kruskal-Wallis test to compare medians. The association between the contraceptive method and the acute painful episodes was evaluated by the Chi-square test. The mean age of women with SCD was 28.3 years and 86.6% were mixed or of African-American ethnicity. With respect to the genotypes, 134 women (84.8%) had HbSS genotype, 12 women (7.6%) had hemoglobin SC (HbSC) disease genotype, and 12 (7.6%) were identified with hemoglobinopathy S-beta (S-β) thalassemia. The mean age of HbSS diagnosis was lower than that of HbSC disease, the less severe form of SCD ( < 0.001). The mean age of menarche was 14.8 ± 1.8 years for HbSS and 12.7 ± 1.5 years for HbSC ( < 0.001). Among women with HbSS who used progestin-only contraception, 16.6% had more than 4 acute painful episodes per year. There was no statistically significant difference when compared with other contraceptive methods. With respect to reproduction-associated variables, only the age of the menarche showed delay in HbSS when compared with HbSC. The contraceptive method used was not associated with the frequency of acute painful episodes among the HbSS women.

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Crescimento e desenvolvimento nas doenças falciformes

Cited by 8 publications

References 23 publications

Sexuality and sickle cell anemia

Sexuality and sickle cell anemia

Growth and puberty in a prospective cohort of patients with sickle-cell anaemia: an assessment over ten years abstract

Profile of Reproductive Issues Associated with Different Sickle Cell Disease Genotypes

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