Growth and puberty in a prospective cohort of patients with sickle-cell anaemia: an assessment over ten years abstract

Gomes, Ingrid Cristiane Pereira; Melo, Hugo Nivaldo; Melo, Suyaluane Italla Amana; Menezes, Nelmo V; Dantas, Túlio Vinicius Paes; Cipolotti, Rosana

doi:10.7322/jhgd.127681

Cited by 5 publications

(7 citation statements)

References 25 publications

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“…The overall prevalence of sub-clinical hypothyroidism reported in the present study is within the range of 2 – 6% reported by previous researchers ( 8 , 26 , 27 ). On the contrary, this reported prevalence rate was lower to what Gomes et al ( 28 ) reported amongst thirty Brazilian children with sickle cell anaemia aged > 10 years. The observed difference is possibly an effect of the characteristics of the population studied.…”

Section: Discussioncontrasting

confidence: 86%

Are We Missing Hypothyroidism among Children with Sickle Cell Anaemia?

Akodu SO,

Adekanmbi AF,

Ogunlesi TA

et al. 2023

Ethiop J Health Sci

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BACKGROUND: Children with sickle cell anaemia have been reported to have potential risk of hypothyroidism from chronic blood transfusions and probable thyroid tissue ischaemia. However, few studies on hypothyroidism status of children with sickle cell anaemia in Nigeria are available. The objective of this study was to determine the prevalence of hypothyroidism among children with sickle cell anaemia. METHODS: A cross sectional study that assayed the thyroid hormones and thyroid stimulating hormone (TSH) of 71 children with sickle cell anaemia was conducted at Olabisi Onabanjo University Teaching Hospital Sagamu. Using age appropriate hormonal reference values, the subjects were classified into sub-clinical, primary and secondary hypothyroidism. RESULTS: The mean serum TSH, Free T3, and Free T4 were comparable irrespective of age category (p > 0.05). No subject was identified to have low TSH value while 7.0% had high TSH value. Low free T3 was identified in 1.4% and 8.5% had high free T3 values. Low free T3 and free T4 were seen in 11.3% each of the subjects. The overall prevalence of primary, secondary and sub-clinical hypothyroidism was 0%, 0% and 4.2%, respectively. CONCLUSION: Sub-clinical hypothyroidism does occur in Nigerian children with sickle cell anaemia. Routine screening for hypothyroidism is advocated in all children with sickle cell anaemia.

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Section: Discussioncontrasting

confidence: 86%

Are We Missing Hypothyroidism among Children with Sickle Cell Anaemia?

Akodu SO,

Adekanmbi AF,

Ogunlesi TA

et al. 2023

Ethiop J Health Sci

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“…Furthermore, the group of patients with SCA had lower anthropometric indices than the control group, a finding related to weight and BMI in agreement with previous studies. 7,29 The findings of increased food intake and reduced anthropometric measurements support the hypercatabolic state of patients with SCA.…”

Section: Discussionmentioning

confidence: 81%

Lipid Profile, Nutritional Status and Severity Biomarkers in Adults With Sickle Cell Anemia

Pereira Gomes,

Costa Machado Teles,

Sousa Coelho

et al. 2023

Clin Med�Insights�Blood�Disord

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BACKGROUND Lipid alterations have been described in sickle cell anemia (SCA), but their association with the disease severity is not fully understood and their correlation with the nutritional status of this population has not been widely studied. OBJECTIVES This study aimed to assess the lipid profile and its relation with the nutritional status, including anthropometric characteristics and daily macronutrient intake, and with the severity biomarkers in adults with SCA in a steady state. DESIGN Cross-sectional study METHODS This was an analytical cross-sectional study with 55 adults with SCA and 60 members of the control group. Sociodemographic, anthropometric, nutritional, and laboratory data were collected between March 2019 and June 2020. Mann–Whitney test was used to compare groups and Spearman's correlation coefficient was used to test the relation between variables. RESULTS The SCA group presented higher calorie, protein, and carbohydrate intake, lower levels of high-density lipoprotein-cholesterol (HDL-c), and a higher triglyceride (TG)/HDL-c ratio than the control. HDL-c showed a positive correlation with hemoglobin and hematocrit (HcT) and a negative correlation with indirect bilirubin and lactate dehydrogenase (LDH). The TG/HDL-c ratio was positively linked with reticulocyte count, LDH, and leukocyte count and negatively linked with Hb. CONCLUSIONS The study findings showed hypocholesterolemia in SCA and its independent correlation with macronutrient intake. The links of HDL-c and TG/HDL-c ratio with hemolysis indices indicate that they are easily accessible, low-cost markers capable of predicting SCA severity.

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“…In the current issue of JHGD these studies evaluate technologies that involve the improvement of health conditions and/or issues for public health investigating the health situation of the population, especially children and adolescents [8][9][10] , which corroborate the themes in the health promotion field within the context of primary care focusing on teens and their vulnerabilities [11][12][13] , nutrition and influence on child and adolescent development [14][15][16][17][18] and themes focused on translational medicine, describing results to improve the health indicators of the population [19][20][21][22] . With an emphasis on nutritional status, to highlight obesity in adolescents, Tebar et al 17 found the prevalence of abdominal obesity in adolescents in the city of Londrina, Paraná, Brazil, and its associated factors.…”

mentioning

confidence: 81%

“…Also in this issue of evaluation of growth and development, Gomes et al 22 evaluated the pattern of growth and pubertal development of a group of patients with Sickle Cell Anaemia (SCA) from childhood to adulthood. Patients with SCA presented growth impairment and pubertal delay when compared to healthy controls.…”

mentioning

confidence: 99%

Translational medicine and its contribution to public health

Bezerra

2017

J. Hum. Growth Dev.

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Abstract:Introduction: Translational medicine is a new paradigm that favors a transfer of knowledge from the lab to the clinical practice. It correlates to the field of Public Health, although there are still challenges. There is a full contribution of Brazil in the theme of Translational Medicine and Public Health. These contributions to public health maximize decision making in health, which is fundamental to maintain a healthy population. Objective: Thus, the Journal of Human Growth and Development has been repository these discussions, contributing to a dissemination of this knowledge worldwide. Different aspects involving clinical practice and public health are highlighted, discussing the real situation of health conditions in the different contexts. These discussions range from the actions to promote health for the population to investigations that bring results, promoting an improvement in health and contributing to the (re)construction of health actions. The importance of researches investigating on means to get the reengineering of the health system is noted. It should consider the needs medical, researchers, managers and users in order to produce knowledge that will become products to improve the health of population.

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Growth and puberty in a prospective cohort of patients with sickle-cell anaemia: an assessment over ten years abstract

Cited by 5 publications

References 25 publications

Are We Missing Hypothyroidism among Children with Sickle Cell Anaemia?

Are We Missing Hypothyroidism among Children with Sickle Cell Anaemia?

Lipid Profile, Nutritional Status and Severity Biomarkers in Adults With Sickle Cell Anemia

Translational medicine and its contribution to public health

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