Obsessive-compulsive disorder and 5-HTTLPR

Rocha, Felipe Filardi da; Marco, Luiz Armando De; Romano-Silva, Marco Aurélio; Corrêa, Humberto

doi:10.1590/s1516-44462009000300021

Cited by 8 publications

(11 citation statements)

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“…2,3 Moreover, OCD is a spectrum disorder with multiple genes involved, each of which contributing only a small fraction to the overall risk. [2][3][4][5] The importance of homogeneous patient groups is exemplified by recent reports that have demonstrated the association between Met allele and the early onset of OCD in males, similarly to the association between the Val66Val genotype and the Val allele in males and OCD patients with sexual/religious obsessions. Furthermore, Met66Met genotype has been previously associated to mild OCD in female patients.…”

Section: Associação Entre O Alelo Met (Polimorfismo Bdnf Val66met) E mentioning

confidence: 98%

“…Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric condition. [2][3][4][5] Considering that the serotonin system plays an important role in the pathogenesis of OCD, the BDNF gene is an interesting candidate gene for OCD. 4,5 BDNF Val66Met is a polymorphism that has been widely investigated in psychiatric disorders.…”

Section: Associação Entre O Alelo Met (Polimorfismo Bdnf Val66met) E mentioning

confidence: 99%

“…[2][3][4][5] Considering that the serotonin system plays an important role in the pathogenesis of OCD, the BDNF gene is an interesting candidate gene for OCD. 4,5 BDNF Val66Met is a polymorphism that has been widely investigated in psychiatric disorders. The Met allele of the BDNF Val66Met polymorphism is associated with reduced BDNF activity and harm avoidance, and it has been suggested that it may be associated with depression, schizophrenia, bipolar disorder and OCD, although findings have been inconsistent.…”

Section: Associação Entre O Alelo Met (Polimorfismo Bdnf Val66met) E mentioning

confidence: 99%

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Positive association between MET allele (BDNF Val66Met polymorphism) and obsessive-compulsive disorder

Rocha

Malloy-Diniz

Lage

et al. 2010

Rev. Bras. Psiquiatr.

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Section: Associação Entre O Alelo Met (Polimorfismo Bdnf Val66met) E mentioning

confidence: 98%

Section: Associação Entre O Alelo Met (Polimorfismo Bdnf Val66met) E mentioning

confidence: 99%

Section: Associação Entre O Alelo Met (Polimorfismo Bdnf Val66met) E mentioning

confidence: 99%

See 1 more Smart Citation

Positive association between MET allele (BDNF Val66Met polymorphism) and obsessive-compulsive disorder

Rocha

Malloy-Diniz

Lage

et al. 2010

Rev. Bras. Psiquiatr.

Self Cite

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“…[1][2][3][4] Thus, the chance of detecting these putative genes may be reduced in a relatively small sample of patients. Therefore, larger and more homogeneous groups are needed to achieve a more accurate characterization of the genetic component of OCD.…”

Section: Discussionmentioning

confidence: 99%

“…A particular emphasis has been placed on genes related to the serotonin system, which is likely to play an important role in the pathogenesis of OCD. [1][2][3][4] The gene for tryptophan hydroxylase (TPH), the rate-limiting step in serotonin (5-HT) synthesis, is an interesting candidate for association analyses. The TPH gene was first identified in 1990 and was believed to be unique.…”

Section: Introductionmentioning

confidence: 99%

Associations between polymorphic variants of the tryptophan hydroxylase 2 gene and obsessive-compulsive disorder

Rocha

Alvarenga

Lage

et al. 2011

Rev. Bras. Psiquiatr.

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OBJECTIVE: A substantial body of evidence suggests that obsessive-compulsive disorder has a genetic component, and substantial candidate genes for the disorder have been investigated through association analyses. A particular emphasis has been placed on genes related to the serotonergic system, which is likely to play an important role in the pathogenesis of obsessive-compulsive disorder. The gene for tryptophan hydroxylase 2, which is a rate limiting enzyme in serotonin synthesis is considered an important candidate gene associated with psychiatric disorders. METHOD: Our sample consisted of 321 subjects (107 diagnosed with obsessive-compulsive disorder and 214 healthy controls), which were genotyped for eight tagSNPs (rs4448731, rs4565946, rs11179000, rs7955501, rs10506645, rs4760820, rs1487275 and rs10879357) covering the entire human tryptophan hydroxylase 2 gene. Statistical analyses were performed using UNPHASED, version 3.0.12, and Haploview ((R)). RESULTS: Single markers, genotype analysis did not show a significant genetic association with obsessive-compulsive disorder. A significant association between the T-C-T (rs4448731, rs4565946, rs10506645) and C-A-T (rs4565946, rs7955501, rs10506645) haplotypes and obsessive-compulsive disorder was observed, as well as a strong linkage disequilibrium between SNPs rs4448731 and rs4565946, and SNPs rs10506645 and 4760820. DISCUSSION: Our research has not demonstrated the existence of associations between the eight SNPs of TPH2 and obsessive-compulsive disorder. However, two LD and two haplotypes areas were demonstrated, thus suggesting that more studies in TPH2 are needed to investigate the role of tryptophan hydroxylase 2 variants in obsessive-compulsive disorder.

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