Implementing Genomics in the Care of Neuropsychiatric Patients in Latin America

Forero, Diego A.; Urriago, Hermes; López-Léon, Sandra; González-Giraldo, Yeimy; Miranda, Débora Marques de; Jovel, Camilo Alfonso Espinosa

doi:10.1016/b978-0-12-811531-2.00005-9

Cited by 3 publications

(1 citation statement)

References 188 publications

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“…American sample. Future studies should analyze variants in MAOA gene and coping and neuroticism in other populations (29,30).…”

Section: Discussionmentioning

confidence: 99%

Association Between a Functional Polymorphism in the MAOA Gene and Both Emotional Coping Style and Neuroticism

López-Léon¹,

Forero

Adán

2019

Preprint

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Objective: Identification of genetic risk factors for major depressive disorder (MDD) represents a major challenge around the world. Molecular studies of endophenotypes associated with MDD, such as personality traits and coping, are useful for the identification of candidate genes. The aim of this study was to evaluate the possible association between a functional polymorphism in the monoamine oxidase A (MAOA) gene and scores in coping and neuroticism in young adults.Results: A sample of 251 healthy young participants from Colombia were evaluated with the short forms of the Coping Inventory for Stressful Situations (CISS-SF) and the Big Five Inventory (BFI-S) and genotyped for MAOA-VNTR polymorphism. A statistically significant association of the functional MAOA-VNTR for scores in both emotion-oriented coping and neuroticism was found. Individuals carrying the 4 allele (3/4 or 4/4 genotypes) had higher scores for both emotion-oriented coping and neuroticism than individuals with a 3/3 genotype. Our results are the first description about a significant association between a functional polymorphism in the MAOA gene and coping and add evidence to the association of this gene with neuroticism. Our findings support the hypothesis of a broad effect of the MAOA gene on several dimensions of human behavior of psychiatric relevance.

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“…American sample. Future studies should analyze variants in MAOA gene and coping and neuroticism in other populations (29,30).…”

Section: Discussionmentioning

confidence: 99%

Association Between a Functional Polymorphism in the MAOA Gene and Both Emotional Coping Style and Neuroticism

López-Léon¹,

Forero

Adán

2019

Preprint

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Genome-Wide Expression Profiles for Ischemic Stroke: A Meta-Analysis

Gutiérrez-Garzón

Barreto

Forero

2018

Journal of Stroke and Cerebrovascular Diseases

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Association Between a Functional Polymorphism in the Monoamine Oxidase A (MAOA) Gene and Both Emotional Coping Style and Neuroticism

Forero¹,

Adán²,

López-Léon³

2020

TONEUJ

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Background: Identification of novel genetic factors for Depressive Disorders (DD) represents a major challenge around the world. Molecular studies of endophenotypes associated with DD, such as personality traits and coping, are powerful strategies for finding genetic markers. Objective: The main objective of this work was to confirm the potential relationship between a functional polymorphism in the monoamine oxidase A (MAOA) gene and scores in coping and neuroticism in young adults. Methods: A Colombian sample of two hundred fifty-one young participants was evaluated with the short forms of the Coping Inventory for Stressful Situations (CISS-SF) and the Big Five Inventory (BFI-S). Genotypes for MAOA-VNTR polymorphism were obtained by PCR. Results: A significant relationship between the functional MAOA-VNTR polymorphism and scores in both emotion-oriented coping and neuroticism was found. Individuals carrying the 4 allele (3/4 or 4/4 genotypes) had higher scores for both emotion-oriented coping and neuroticism than individuals with a 3/3 genotype. Conclusion: Our current findings are novel in terms of being the first report of a relationship between a functional polymorphism in the MAOA gene and coping and add evidence to the association of this gene with neuroticism. Our results expand the associations between MAOA gene and multiple dimensions of human emotion and personality.

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Implementing Genomics in the Care of Neuropsychiatric Patients in Latin America

Cited by 3 publications

References 188 publications

Association Between a Functional Polymorphism in the MAOA Gene and Both Emotional Coping Style and Neuroticism

Association Between a Functional Polymorphism in the MAOA Gene and Both Emotional Coping Style and Neuroticism

Genome-Wide Expression Profiles for Ischemic Stroke: A Meta-Analysis

Association Between a Functional Polymorphism in the Monoamine Oxidase A (MAOA) Gene and Both Emotional Coping Style and Neuroticism

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