PANDAS - Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infection: constitui-se num transtorno clínico específico?

Singer, Harvey S.

doi:10.1590/s1516-44462004000400002

Cited by 3 publications

(3 citation statements)

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“…Because the goal of this article is to review neurobiology rather than diagnostic controversies, the reader is referred to other sources for an update on this ongoing debate. [3][4][5][6][7]…”

Section: Clinical Descriptive and Diagnostic Featuresmentioning

confidence: 99%

Tic Disorders: Neural Circuits, Neurochemistry, and Neuroimmunology

2006

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The neuroanatomy and neurochemistry underlying tic disorders are thought to involve corticostriatothalamocortical circuits and dysregulation of their component neurotransmitter systems. Tourette syndrome is a tic disorder that begins in childhood and follows a waxing and waning course of tic severity. Although it is generally believed to have a genetic component, its etiology has not been fully elucidated. The clinical entity pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) has led some to suggest that the pathophysiology of tics in some individuals might involve a postinfectious autoimmune component. We review the neural circuits and neurochemistry of Tourette syndrome and evaluate the evidence for and against a role for autoimmunity in the expression of tics.

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Section: Clinical Descriptive and Diagnostic Featuresmentioning

confidence: 99%

Tic Disorders: Neural Circuits, Neurochemistry, and Neuroimmunology

2006

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“…3 Their striking finding is that the large majority of psychiatric exacerbations in this subgroup of patients could not be related to the acute group A ␤-hemolytic streptococcal (GABHS) infections, contradicting the hallmark of the PANDAS hypothesis. 1 Their findings suggest that obsessive-compulsive disorder (OCD) and Tourette syndrome are complex and heterogeneous conditions that may include subgroups prone to be triggered by a possible array of precipitants, including GABHS infections.…”

Section: The Role Of Group a ␤-Hemolytic Streptococcal Infection In Nmentioning

confidence: 88%

The Role of Group A β-Hemolytic Streptococcal Infection in Neuropsychiatric Disorders

2008

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“…En 1998, Swedo et al 11 describieron un subgrupo de niños en los cuales los tics y/o sín-tomas obsesivo-compulsivos estaban asociados a la ocurrencia de una infección estreptocócica, una patología que fue designada como pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). La existencia de esta patología genera, sin embargo, mucha controversia 3,4,8,[12][13][14][15][16][17][18] .…”

Section: Introductionunclassified