The Role of Group A β-Hemolytic Streptococcal Infection in Neuropsychiatric Disorders

Alvarenga, Pedro Gomes de; Hounie, Ana Gabriela; Miguel, Eurí­pedes Constantino

doi:10.1542/peds.2008-2118

Cited by 6 publications

(4 citation statements)

References 10 publications

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“…20 Hence, future prospective, systematic longitudinal studies evaluating environmental factors in individuals at risk are warranted especially to investigate the possible relation between infection (i.e., group A beta-hemolytic streptococcal infection), the immunological system and the development of OCD. 21 Despite the negative results of the present investigation, future studies with NFKBIL polymorphisms are welcomed because of the interesting region where this gene is located. The NFKBIL is around 30 kb to the TNF-α at the telomeric end of the central MHC region.…”

Section: Resultsmentioning

confidence: 69%

Association study between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder

Cordeiro

Cappi

Sampaio

et al. 2009

Rev. Bras. Psiquiatr.

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Section: Resultsmentioning

confidence: 69%

Association study between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder

Cordeiro

Cappi

Sampaio

et al. 2009

Rev. Bras. Psiquiatr.

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“…19,20 Neurological manifestation may cause or exacerbate pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS), a disorder that is not yet established as a unique clinical entity (Figure 1). [21][22][23] As recently summarized by Tandon et al, the histopathology of ARF indicates that extracellular matrix (ECM) components are the common target of autoimmune responses in the various manifestations of ARF. Most of the affected tissues heal completely after the acute episode of ARF and no visible damage remains.…”

Section: Arf and Rhd Pathology Of Arf And Rhdmentioning

confidence: 99%

Challenges to developing effective streptococcal vaccines to prevent rheumatic fever and rheumatic heart disease

Sharma¹,

Nitsche-Schmitz²

2014

VDT

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Acute rheumatic fever is a sequela of Streptococcus pyogenes and potentially of Streptococcus dysgalactiae subsp. equisimilis infections. Acute rheumatic fever is caused by destructive autoimmunity and inflammation in the extracellular matrix and can lead to rheumatic heart disease, which is the most frequent cardiologic disease that is acquired in youth. Although effective treatments are available, acute rheumatic fever and rheumatic heart disease remain serious threats to human health, which affect millions and cause high economic losses. This has motivated the search for a vaccine that prevents the causative streptococcal infections. A variety of potential vaccine candidates have been identified and investigated in the past. Today, new approaches are applied to find alternative candidates. Nevertheless, several obstacles lie in the way of an approved S. pyogenes vaccine for use in humans. Herein, a subjective selection of promising vaccine candidates with respect to the prevention of acute rheumatic fever/rheumatic heart disease and safety regarding immunological side effects is discussed.

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“…Analysis of all the randomized, controlled trials demonstrates a significant decrease in this combined outcome of invasive Candida infection or mortality (odds ratio: 0.36 [95% confidence interval: 0.23-0.58]; P Ͻ .0001) ( Table 1). On the basis of data from the Centers for Disease Control and Prevention, 8 nearly 30 000 patients are born at Ͻ1000 g each year in the United States, which translates into ϳ3000 invasive Candida infections, 400 Candida-related deaths, and 1500 infants developing NDI. It is important to note that fluconazole does not have any mechanism that would increase NDI.…”

Section: Fluconazole Prophylaxis Decreases the Combined Outcome Of Inmentioning

confidence: 99%