Tics en niños y adolescentes: análisis retrospectivo de 78 casos

Prior, C.; Tavares, Susana M.; Figueiroa, Sónia; Temudo, Teresa

doi:10.1157/13098929

Cited by 13 publications

(3 citation statements)

References 24 publications

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“…In our study, a diagnosis of PANDAS was made in 24 (60%) out 40 children with motor tics referred by pediatric neurologists and neuropsychiatrists to our Unit. Conversely, in the report by Catarina Prior et al [27] only five (6.4%) out seventy-eight children with motor tics had PANDAS. This discrepancy may be explained by differences in data collection from clinical records.…”

Section: Discussionmentioning

confidence: 79%

Ocular Tics and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS)

Dore,

Satta,

Zinellu

et al. 2024

Diseases

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Little is known about ocular tics in Pediatric Autoimmune Neuropsychiatric Disorders associated with Streptococcal infections (PANDAS). In this retrospective study, we examined the clinical records of children with motor tics referred to the Ophthalmology Unit, Azienda Ospedaliero-Universitaria di Sassari, Italy, in 2010–2019. The presence of ocular tics was investigated. Data about antistreptolysin O (ASO) and anti-DNase B antibody titers, erythrocyte sedimentation rate (ESR), plasma C-reactive protein (CRP), and antibiotic use were recorded. Forty children (thirty-four boys and six girls; mean age: 7.65 ± 2.5 years) with motor tics were identified; thirty-three (82.5%) showed ocular tics. Children with ocular tics had significantly higher titers of anti-DNase B antibodies (p = 0.04) and CRP (p = 0.016) than those with extraocular tics. A diagnosis of PANDAS was made in 24 (60%) children. PANDAS children with oculomotor tics had significantly higher titers of anti-DNase B antibodies (p = 0.05) than those with extraocular tics. Oral antibiotics were given to 25/33 (76%) children with ocular tics and 21/24 (87.5%) with PANDAS. All treated patients showed marked improvement/complete resolution of symptoms. Results suggest that higher titers of anti-DNase B antibodies may be implicated in the pathogenesis of ocular tics in PANDAS. Oral antibiotics may be beneficial in improving ocular tics. Further research is necessary to confirm our findings.

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Section: Discussionmentioning

confidence: 79%

Ocular Tics and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS)

Dore,

Satta,

Zinellu

et al. 2024

Diseases

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“…Twenty-nine patients with a diagnosis of TS without comorbidities (attention-deficit/hyperactivity disorder or obsessive-compulsive disorder) according to Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) (16), and 20 healthy subjects were recruited for our study. All patients underwent a complete neurological examination, which revealed no additional abnormalities.…”

Section: Participantsmentioning

confidence: 99%

The Suppressive Effect of the Motor System on the Sensory System in Patients With Tourette Syndrome

et al. 2020

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Objective: Tourette syndrome (TS) is a complicated sensorimotor disorder. Some patients with TS relieve their involuntary premonitory urges via tics. However, the effect of the motor system on the sensory system has not yet been elucidated. The purpose of the present study was to investigate changes in the excitability of the sensory cortex following repetitive transcranial magnetic stimulation (rTMS) of the motor cortex in patients with TS. Methods: Twenty-nine patients with TS and 20 healthy, age-matched controls were enrolled in this study. All subjects were divided into four groups: patients with rTMS, patients with sham-rTMS, controls with rTMS, and controls with sham-rTMS. The clinical severity of tics was evaluated using the Yale Global Tic Severity Scale. Single somatosensory evoked potentials (SEPs) and paired SEPs were recorded by stimulating the median nerve at the wrist of all subjects. The resting motor threshold (RMT) was tested in each subject in the rTMS group. Afterwards, all four groups were administered rTMS (1 Hz, 90% RMT) or sham-rTMS for 200 s, followed by a 15-min rest. Finally, single SEPs and paired SEPs were repeated for each subject. Results: No significant differences in RMT, the amplitudes of single SEPs, or the suppression of paired SEPs were observed between patients with TS and controls at baseline. After rTMS, a significant suppression of the peak-to-peak amplitude of the N20-P25 responses of single SEPs was observed in both controls (p = 0.049) and patients (p < 0.0001). The suppression of the N20-P25 peak-to-peak amplitude was more significant in patients than in controls (p = 0.039). A significant difference in the suppression of paired SEPs after rTMS was not observed between groups. Conclusions: The more significant suppression of N20-P25 components of single SEPs with normal suppressed paired SEPs in patients with TS after 1-Hz rTMS of the motor cortex suggests that the suppressive effect of the motor system on the sensory system might originate from the motor-sensory cortical circuits rather than the sensory system itself.

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“…Se caracterizan por ser movimientos o sonidos involuntarios, repetitivos, y frecuentemente hereditarios (Cubo et al, 2013). Característicamente, los tics suelen presentar diferentes trastornos neuropsiquiátricos asociados como son el trastorno de déficit de atención e hiperactividad (60%), trastorno obsesivo compulsivo (40%) y otros trastornos conductuales (Catarina, Tavares, Figueiroa & Temudo, 2007). Este conjunto de síntomas hacen que estos trastornos un reconocido impacto tanto a nivel de participación social -handicap-como a la calidad de vida (Eirís-Puñal, 2014).…”

Section: Introductionunclassified

Los tics y su relación con las dificultades de aprendizaje: estudio longitudinal de la prevalencia de los tics primarios y comorbilidad asociada en población escolar.

2017

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Con el objetivo de estudiar la prevalencia de los trastornos con tics y la asociación con las dificultades de aprendizaje, se realizó un estudio epidemiológico en una muestra de 1.139 escolares. Los resultados señalaron una prevalencia del 16,86% (IC 95% del 14,10 – 19,63). Además se encontraron dificultades académicas en el 11,9% de los escolares, y la presencia de tics en el 8,6%. La presencia de trastornos de tics no se asoció con el bajo rendimiento académico en la cohorte. Los resultados obtenidos fueron contradictorios con relación a otros estudios publicados anteriormente. Como consecuencia de la divergencia en los resultados, se diseña un segundo estudio, que toma como punto de partida el seguimiento longitudinal de la cohorte de los escolares estudiados. En el análisis de regresión de Cox, durante el periodo de seguimiento de 4 años, la repetición de curso se asoció con una menor frecuencia de apoyo psicológico en el centro escolar (HR = 17,5; IC del 95% 5,7 a 53,9) y menor practica de deporte (HR = 4,02, 95% CI 01/03 a 11/08). No se encontró una asociación entre los tics y mayor riesgo de repetir curso.

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Tics en niños y adolescentes: análisis retrospectivo de 78 casos

Cited by 13 publications

References 24 publications

Ocular Tics and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS)

Ocular Tics and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS)

The Suppressive Effect of the Motor System on the Sensory System in Patients With Tourette Syndrome

Los tics y su relación con las dificultades de aprendizaje: estudio longitudinal de la prevalencia de los tics primarios y comorbilidad asociada en población escolar.

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