The aim of this study was to evaluate the chemical profile, somatic cell count (SCC) and milk production of Holstein, Girolando and Jersolando cows. Fresh milk samples were collected from 34 high-production cows, averaging 31 L/day, belonging to three genetic groups (Holstein, Girolando and Jersolando). Experimental design was completely randomized, in which data collected were submitted to analysis of variance considering the effects of genetic group on milk quality and production. Correlations between milk volume and fat, protein, lactose, total dry extract, defatted dry extract and SCC were assessed. Jersolando herd produced milk with higher content of solids compared to the Holstein and Girolando. In relation to milk production, Girolando cows stood out over the others. Correlations between volume and fat, protein, total dry extract and defatted dry extract were negative; however, lactose showed positive correlation. The dairy system evaluated in this study demonstrated potential to meet the quality requirements of milk related to SCC in the current period and also from 2014, showing that large investments in facilities are not required to obtain quality milk.