Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study

Kraychete, Durval Campos; Sakata, Rioko Kimiko; Issy, Adriana Machado; Bacellar, Olı́via; Santos-Jesus, Rogério; Carvalho, Edgar M.

doi:10.1590/s1516-31802010000500003

Cited by 81 publications

(66 citation statements)

References 34 publications

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“…Some studies of trauma or chronic pain do report correlation between IL-6 and symptom severity [26,42,57,103], but circulating IL-6 levels are likely to be much higher in these populations (e.g. chronic LBP [60,117]) than the acute LBP group reported here. The few studies that have examined IL-6 in acute conditions report similar findings to the present study.…”

Section: Il-6 Elevated Only In High-paincontrasting

confidence: 50%

Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain

Klyne

Barbe

Hodges

2017

Brain, Behavior, and Immunity

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Please cite this article as: Klyne, D.M., Barbe, M.F., Hodges, P.W., Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain, Brain, Behavior, and Immunity (2016), doi: http://dx.doi.org/10. 1016/j.bbi.2016.10.003 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. and control participants, and in a separate analysis, for those with "high-pain" (VAS≥4) and "low-pain" (VAS<4). The relationships between biomarkers and all other variables, including other cytokines/CRP were assessed. CRP was higher in LBP than controls and in those with high-than low-pain (p<0.01). IL-6 was higher in those with high-than low-pain (p<0.05), but not controls. Various pain and non-pain factors were associated with each biomarker differently. These findings suggest systemic CRP and IL-6 are important contributors to inflammation in the early post-onset phase of LBP and that various factors can shape these responses.3

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Section: Il-6 Elevated Only In High-paincontrasting

confidence: 50%

Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain

Klyne

Barbe

Hodges

2017

Brain, Behavior, and Immunity

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“…The absence of a relationship between pain scores and intercellular proinflammatory cytokines level in this study was statistically insignificant, possibly due to the small sample size. However, in their study Kraychete et al did not find any correlation between blood serum levels of TNF-α or IL-6 and pain intensity, or the duration of pain among patients with low back pain (55). In contrast, Koch et al reported that the serum level of proinflammatory cytokine (IL-1-β, IL-2, IL-6, IFN-g and TNFα) correlated significantly with increased pain intensity in patients experiencing chronic pain (56).…”

Section: Discussionmentioning

confidence: 74%

Immune responses following McKenzie lumbar spine exercise in individuals with acute low back pain: A preliminary study

Al‐Obaidi

Mahmoud

2014

AMA

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Objective. This study explores the immune responses following 4 weeks of McKenzie lumbar spine exercise in individuals with acute low back pain (ALBP). Patients and methods. Fifteen patients with ALBP and 15 healthy individuals volunteered in this study. Ten ml of peripheral blood were obtained from each patient before and after exercise sessions, and from healthy individuals at the beginning of the study.

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“…Chen et al found that the bacterium was able to induce disc degeneration outright in rabbit models [28]. Furthermore, long-term antibiotics targeting anaerobes may improve lower back pain in those with disc herniation and vertebral edema [22]. Despite this, however, other studies have failed to correlate P. acnes prevalence with LDH pathology [29].…”

Section: Propionibacterium Acnesmentioning

confidence: 99%

Lumbar Disc Herniation

Amin

Andrade

Neuman³

2017

Curr Rev Musculoskelet Med

207

202

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Purpose of Review Substantial advancements have been made in the cause, diagnosis, imaging, and treatment options available for patients with lumbar disc herniation (LDH). We examined the current evidence and highlight the concepts on the frontline of discovery in LDH. Recent Findings There are a myriad of novel etiologies of LDH detailed in recent literature including inflammatory factors and infectious microbes. In the clinical setting, recent data focuses on improvements in computer tomography as a diagnostic tool and non-traditional injection options including tumor necrosis alpha inhibitors and platelet-rich plasma. Operative treatment outcomes have focused on minimally invasive endoscopic approaches and demonstrated robust 5-year post-operative outcomes. Summary Advances in the molecular etiology of LDH will continue to drive novel treatment options. The role of endoscopic treatment for LDH will continue to evolve. Further research into10-year outcomes will be necessary as this surgical approach continues to gain widespread popularity.

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Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study

Cited by 81 publications

References 34 publications

Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain

Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain

Immune responses following McKenzie lumbar spine exercise in individuals with acute low back pain: A preliminary study

Lumbar Disc Herniation

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