Immune responses following McKenzie lumbar spine exercise in individuals with acute low back pain: A preliminary study

Al‐Obaidi, Saud; Mahmoud, Fadia

doi:10.5644/ama2006-124.96

Cited by 7 publications

(8 citation statements)

References 50 publications

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“… Al-Obaidi & Mahmoud (2014) recently reported on a study with characteristics similar to ours, which found increased production of pro-inflammatory cytokine TNF- α after treatment, but no change in IL-6 production. The author justified this result by stating that overexpression of TNF- α and other pro-inflammatory cytokines occurs in many studies of low-back pathologies ( Takahashi et al, 1996 ).…”

Section: Discussionsupporting

confidence: 74%

Effectiveness of specific stabilization exercise compared with traditional trunk exercise in women with non-specific low back pain: a pilot randomized controlled trial

Minobes-Molina

Nogués

Giralt

et al. 2020

PeerJ

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Background Non-specific low back pain (LBP) is the leading cause of disability worldwide. The primary physiotherapeutic treatment for LBP is physical exercise, but evidence suggesting a specific exercise as most appropriate for any given case is limited. Objective To determine if specific stabilization exercise (SSE) is more effective than traditional trunk exercise (TTE) in reducing levels of pain, disability and inflammation in women with non-specific low back pain (LBP). Design A pilot randomized controlled trial was conducted in Rovira i Virgili University, Catalonia. Methods Thirty-nine females experiencing non-specific LBP were included in two groups: the TTE program and SSE program, both were conducted by a physiotherapist during twenty sessions. The primary outcome was pain intensity (10-cm Visual Analogue Scale). Secondary outcomes were disability (Roland Morris Disability Questionnaire), and inflammation (IL-6 and TNF-α plasma levels). Measurements were taken at baseline, at half intervention, at post-intervention, and a month later. Results Mean group differences in change from baseline to post-intervention for TTE were: −4.5 points (CI 3.3 to 5.6) for pain, −5.1 points (CI 3.0 to 7.3) for disability, 0.19 pg/mL (95% CI [−1.6–1.2]) for IL-6 levels, and 46.2 pg/mL (CI 13.0 to 85.3) for TNF-α levels. For SSE, differences were: −4.3 points (CI 3.1 to 5.6) for pain, −6.1 points (CI 3.7 to 8.6) for disability, 1.1 pg/mL (CI 0.0 to 2.1) for IL-6 levels , and 12.8 pg/mL (95% CI [−42.3–16.7]) for TNF-α levels. There were an insignificant effect size and no statistically significant overall mean differences between both groups. Conclusion This study suggests that both interventions (traditional trunk and specific stabilization exercises) are effective in reducing pain and disability in non-specific LBP patients, but the two programs produce different degrees of inflammation change. Clinical trial registration number NCT02103036.

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Section: Discussionsupporting

confidence: 74%

Effectiveness of specific stabilization exercise compared with traditional trunk exercise in women with non-specific low back pain: a pilot randomized controlled trial

Minobes-Molina

Nogués

Giralt

et al. 2020

PeerJ

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“…Our results with regard to inflammation indicate that, following TTEP, TNF-α levels had increased; when SSEP was used, IL-6 levels had increased by the end of our 20-session course of treatment. Al-Obaid et al, recently reported on a study with characteristics similar to ours, which found increased production of pro-inflammatory cytokine TNF-α after treatment, but no change in IL-6 production (Al-Obaidi & Mahmoud, 2014). The author justified this result by stating that overexpression of TNF-α and other pro-inflammatory cytokines occurs in many studies of lowback pathologies (Takahashi et al, 1996).…”

Section: Discussionsupporting

confidence: 63%

Peer Review #3 of "Effectiveness of specific stabilization exercise compared with traditional trunk exercise in women with non-specific low back pain: a pilot randomized controlled trial (v0.1)"

2020

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Background. Non-specific low back pain (LBP) is the leading cause of disability worldwide. The primary physiotherapeutic treatment for LBP is physical exercise, but evidence suggesting a specific exercise as most appropriate for any given case is limited. Objective. To determine if specific stabilization exercise (SSE) is more effective than traditional trunk exercise (TTE) in reducing levels of pain, disability and inflammation in women with non-specific low back pain (LBP). Design. A pilot randomized controlled trial was conducted in Rovira i Virgili University, Catalonia. Methods. 39 females experiencing non-specific LBP were included in two groups: the TTE program and SSE program, both were conducted by a physiotherapist during twenty sessions. The primary outcome was pain intensity (10-cm Visual Analogue Scale). Secondary outcomes were disability (Roland Morris Disability Questionnaire), and inflammation (IL-6 and TNF-α plasma levels). Measurements were taken at baseline, at half intervention, at post-intervention, and a month later. Results: Mean group differences in change from baseline to post-intervention for TTE were:-4.5 points (CI 3.3 to 5.6) for pain,-5.1 points (CI 3.0 to 7.3) for disability, 0.19 pg/mL (95% CI-1.6 to 1.2) for IL-6 levels, and 46.2 pg/mL (CI 13.0 to 85.3) for TNF-α levels. For SSE, differences were:-4.3 points (CI 3.1 to 5.6) for pain,-6.1 points (CI 3.7 to 8.6) for disability, 1.1 pg/mL (CI 0.0 to 2.1) for IL-6 levels , and 12.8 pg/mL (95% CI-42.3 to 16.7) for TNF-α levels. There were an insignificant effect size and no statistically significant overall mean differences between both groups. Conclusion: This study suggests that both interventions (traditional trunk and specific stabilization exercises) are effective in reducing pain and disability in non-specific LBP patients, but the two programs produce different degrees of inflammation change. Clinical trial registration number: NCT02103036.

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“…However, the mechanisms of the immune system’s action on LDH have been discussed in various studies, mainly focusing on cytokine and immunoglobulins ( Naylor et al, 1975 ; Miyamoto et al, 2000 ; Shamji et al, 2010 ). Regarding immune factors, previous studies ( Miyamoto et al, 2000 ; Shamji et al, 2010 ; Al-Obaidi and Mahmoud, 2014 ; Djuric et al, 2020 ) detected the presence of large amounts of IL-1β, IL-17, and IL-10 in the intervertebral discs of patients with LDH and investigated the mechanism of their action on LDH. The results showed a significant negative correlation between the concentrations of IL-1β and IL-17 and the condition of LDH ( Al-Obaidi and Mahmoud, 2014 ; Tan et al, 2022 ).…”

Section: Biological Mechanisms Of Exercise In the Treatment Of Ldhmentioning

confidence: 99%

“…Regarding immune factors, previous studies ( Miyamoto et al, 2000 ; Shamji et al, 2010 ; Al-Obaidi and Mahmoud, 2014 ; Djuric et al, 2020 ) detected the presence of large amounts of IL-1β, IL-17, and IL-10 in the intervertebral discs of patients with LDH and investigated the mechanism of their action on LDH. The results showed a significant negative correlation between the concentrations of IL-1β and IL-17 and the condition of LDH ( Al-Obaidi and Mahmoud, 2014 ; Tan et al, 2022 ). At the same time, IL-10, a critical immunosuppressive factor, had a significant positive correlation with the condition of LDH ( Uçeyler et al, 2007 ).…”

Section: Biological Mechanisms Of Exercise In the Treatment Of Ldhmentioning

confidence: 99%

Clinical effects and biological mechanisms of exercise on lumbar disc herniation

Wang,

Liu,

Gao

et al. 2024

Front. Physiol.

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Lumbar Disc Herniation (LDH) is a syndrome in which lumbar disc degeneration, rupture of the annulus fibrosus, and herniation of the nucleus pulposus irritate and compress the nerve roots and cauda equina, resulting in the main manifestations of lumbar pain and/or lower extremity pain. There is evidence in various clinical areas that exercise is effective in treating LDH, and exercise intervention for more than 2 weeks reduces disease activity in LDH. However, the mechanism of exercise’s action in reducing disease activity in LDH is unclear. In this article, we first summarize and highlight the effectiveness of exercise in treating LDH and provide guideline recommendations regarding exercise type, intensity, frequency, and duration. Then, we integrate the existing evidence and propose biological mechanisms for the potential effects of exercise on neuromechanical compression, inflammatory chemical stimuli, and autoimmune responses from the perspective of LDH pathogenesis as an entry point. However, a large body of evidence was obtained from non-LDH populations. Future research needs to investigate further the proposed biological mechanisms of exercise in reducing disease activity in LDH populations. This knowledge will contribute to the basic science and strengthen the scientific basis for prescribing exercise therapy for the routine clinical treatment of LDH.

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Immune responses following McKenzie lumbar spine exercise in individuals with acute low back pain: A preliminary study

Cited by 7 publications

References 50 publications

Effectiveness of specific stabilization exercise compared with traditional trunk exercise in women with non-specific low back pain: a pilot randomized controlled trial

Effectiveness of specific stabilization exercise compared with traditional trunk exercise in women with non-specific low back pain: a pilot randomized controlled trial

Peer Review #3 of "Effectiveness of specific stabilization exercise compared with traditional trunk exercise in women with non-specific low back pain: a pilot randomized controlled trial (v0.1)"

Clinical effects and biological mechanisms of exercise on lumbar disc herniation

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