Predictors of quality-of-life improvement following pulmonary resection due to lung cancer

Saad, Ivete Alonso Bredda; Botega, Neury José; Toro, Ivan Felizardo Contrera

doi:10.1590/s1516-31802007000100009

Cited by 29 publications

(28 citation statements)

References 20 publications

(18 reference statements)

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“…(23,27) One study demonstrated that, within one month of the surgery, lower values are obtained for most scales, and that these values return to preoperative levels from the third month onward. (28) The authors of that study also reported that cancer patients presented a worse initial QoL than did the general population, and that, except for general health, the scores on all scales remained below 50% in cancer patients even after the third postoperative month, which is in accordance with our results.…”

Section: Discussionmentioning

confidence: 99%

Avaliação da função pulmonar e da qualidade de vida em pacientes submetidos à ressecção pulmonar por neoplasia

et al. 2009

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Objective: To evaluate the effects that pulmonary resection has on pulmonary function and quality of life (QoL) in patients with primary or metastatic lung cancer. Methods: This was a prospective cohort study involving all patients submitted to pulmonary resection for cancer between September of 2006 and March of 2007 at the A. C. Camargo Hospital in São Paulo, Brazil. Patients underwent spirometry in the preoperative period and at six months after the surgical procedure. After a postoperative period of six months, the patients completed an overall QoL questionnaire (the Medical Outcomes Study 36-item Short-form Health Survey) and another one, specific for respiratory symptoms (the Saint George's Respiratory Questionnaire). The scores obtained in our study were compared with those previously obtained for a general population and for a population of patients with COPD. Results: We included 33 patients (14 males and 19 females), ranging in age from 39 to 79 years. All of the patients, smokers and nonsmokers alike, presented significant worsening of pulmonary function. The mean scores on the overall QoL questionnaire were approximately 5% lower than those obtained for the general population. The scores of various domains of the symptom-specific QoL questionnaire were 50-60% lower than those obtained for the general population and approximately 20% higher than those obtained for the population with COPD. Conclusions: Pulmonary resection has a direct negative impact on pulmonary function and QoL, especially on the QoL related to aspects directly linked to pulmonary function. We highlight the importance of preoperative assessment of pulmonary function in patients undergoing pulmonary resection, in order to predict their postoperative evolution.Keywords: Thoracic surgery; Lung neoplasms/surgery; Spirometry; Quality of life; Questionnaires. ResumoObjetivo: Avaliar as repercussões da ressecção pulmonar sobre a função pulmonar e a qualidade de vida (QV) de pacientes com câncer de pulmão primário ou metastático. Métodos: Estudo de coorte prospectivo que incluiu todos os pacientes que realizaram ressecção pulmonar por neoplasia no Hospital A. C. Camargo entre setembro de 2006 e março de 2007. Os pacientes foram avaliados no pré-operatório e após seis meses do procedimento cirúr-gico através de espirometria. Após seis meses de pós-operatório, os pacientes responderam a um questionário de QV geral (Medical Outcomes Study 36-item Short-form Health Survey) e um específico para sintomas respiratórios (Saint George's Respiratory Questionnaire). Os valores de QV obtidos foram comparados a valores de uma população geral e aos de uma população de portadores de DPOC. Resultados: Foram incluídos 33 pacientes (14 homens e 19 mulheres), com idade entre 39 e 79 anos. Todos os pacientes, tabagistas ou não, apresentaram piora significativa da função pulmonar. Observamos uma redução de aproximadamente 5% na média dos escores do questionário de QV geral em comparação àquela da população geral. Houve uma redução de 50-60% nos vários d...

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Section: Discussionmentioning

confidence: 99%

Avaliação da função pulmonar e da qualidade de vida em pacientes submetidos à ressecção pulmonar por neoplasia

et al. 2009

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“…Thirteen studies evaluated the HRQoL of patients by performing therapeutic interventions, distributed as follows: six were on physical interventions (12)(13)(14)(15)(16)(17) , four were on emotional interventions (18)(19)(20)(21) , and three were on spiritual interventions (22)(23)(24) (Chart 1). Finally, eight studies addressed the signs and the symptoms that negatively affected the HRQoL of patients with advanced cancer (25)(26)(27)(28)(29)(30)(31)(32) (Chart 2).…”

Section: Characterization Of the Studiesmentioning

confidence: 99%

“…Among the studies that reported results that positively affected the HRQoL of patients after performing physical (12)(13)(14)(15)(16)(17) interventions, the highlights were three interventions with invasive procedure (12)(13)(14) , two with pharmacological interventions (15)(16) and one with alternative therapy (17) .…”

Section: Interventions Outcomesmentioning

confidence: 99%

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Health-related quality of life among patients with advanced cancer: an integrative review

Freire

Sawada

França

et al. 2014

Rev. esc. enferm. USP

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RESUMENEsta revisión integradora de la literatura tuvo como objetivo caracterizar los artícu-los de la literatura nacional e internacional que abordan la calidad de vida relacionada con la salud (CVRS) de los pacientes con cáncer avanzado y resumir los factores evidenciados en la literatura que contribuyen a mejorarla o empeorarla. La búsqueda se realizó en las bases de datos electrónicas CINHAL, EMBASE, LILACS, SCIELO y PUB-MED. De los 21 artículos de la muestra, 13 estudios mostraron una mejoría de la CVRS de los pacientes con cáncer avanzado mediante la realización de intervenciones físicas, emocionales y espirituales. En ocho estudios se identificaron signos y síntomas predictores de baja de la CVRS citados como dolor, fatiga, trastornos del sueño, depresión, cambios nutricionales, entre otros. Los resultados muestran que las manifestaciones clínicas inherentes al cáncer son factores que pueden reducir la CVRS del paciente, mientras que los beneficios físicos, psicológicos y espirituales resultantes de las intervenciones terapéuticas pueden promover su mejora. DESCRIPTORES Neoplasias Enfermo terminal Calidad de vida Enfermería oncológica Revisión RESUMOEsta revisão integrativa da literatura objetivou caracterizar artigos abordando a qualidade de vida relacionada à saúde -QVRS -de pacientes com câncer avança-do nas literaturas nacional e internacional e sumarizar os fatores contribuintes para a melhora ou a piora da QVRS de pacientes com câncer avançado, evidenciados na literatura pesquisada. A busca foi realizada nas bases eletrônicas CINHAL, EMBA-SE, PUBMED, SCIELO e LILACS. Dentre os 21 artigos que compuseram a amostra, 13 evidenciaram melhora da QVRS de pacientes com câncer avançado mediante a realização de intervenções físicas, emocionais e espirituais. Em oito estudos, foram identificados sinais e sintomas preditores de baixa QVRS, como dor, fadiga, distúrbio do sono, depressão, alterações nutricionais, entre outros. Os resultados mostram que manifestações clínicas inerentes ao câncer são fatores que podem rebaixar a QVRS do paciente, enquanto os benefícios físicos, psicológicos e espirituais resultantes de intervenções terapêuticas, podem promover a melhora. DESCRITORES Neoplasias Doente terminal Qualidade de vida Enfermagem oncológica Revisão ABSTRACTThis integrative literature review aimed to characterize scientific articles on healthrelated quality of life -HRQoL -among patients with advanced cancer from national and international literature, and summarize those factors evidenced in the literature that contributed to the improvement or worsening of HRQoL among patients with advanced cancer. The search for materials was conducted in the following databases: CINAHL, EMBASE, PubMed, SciELO and LILACS. Among the 21 articles in the sample, 13 showed an improvement of HRQoL among patients with advanced cancer related to the development of physical, emotional and spiritual interventions. In eight studies, we identified predictive symptoms of low HRQoL, such as pain, fatigue, sleep disorders, depression, nu...

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“…5 Currently, many therapeutic options are possible for NSCLC treatment: surgery for the early stages, and also target therapies for advanced cases with good performance status. 2,7 We believe that taking genome studies into consideration in identifying populations at risk could improve NSCLC screening strategies and therefore would help oncologists to implement prompt approaches. …”

mentioning

confidence: 99%

Loci identified through genome-wide association studies and lung cancer risk: is there anything more?

et al. 2013

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and rs931794 on 15q25 modified the effect of cumulative tobacco smoking on lung cancer risk, but that these two loci showed no statistically significant main effects on lung cancer risk. Furthermore, they reported that the associations shown by the TERT-CLPM1L locus on 5p15 with lung cancer risk among Japanese patients were of a similar magnitude to those among Western patients. 4 Meanwhile, a Portuguese study 5 reported that epidermal growth factor (EGF)+61 genetic A/G polymorphisms were also associated with increased risk of NSCLC in a Portuguese population. EGF +61 A/G genetic polymorphisms are located on chromosome 4 and have also previously been reported to be risk factors for glioma and predictive biomarkers for cetuximab in colorectal cancer cases. 5In this manner, the genome has now acquired a central role in NSCLC susceptibility. 3-6Recent studies have shown that low-dose computed tomography could serve as an important screening tool in selected populations. 5 Currently, many therapeutic options are possible for NSCLC treatment: surgery for the early stages, and also target therapies for advanced cases with good performance status. 2,7 We believe that taking genome studies into consideration in identifying populations at risk could improve NSCLC screening strategies and therefore would help oncologists to implement prompt approaches.

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Predictors of quality-of-life improvement following pulmonary resection due to lung cancer

Abstract: The predictors that affected QoL positively were better FVC and 6-MWT results and less extensive lung resection. Three months after the surgery, an improvement in social life was already seen.

Cited by 29 publications

References 20 publications

Avaliação da função pulmonar e da qualidade de vida em pacientes submetidos à ressecção pulmonar por neoplasia

Avaliação da função pulmonar e da qualidade de vida em pacientes submetidos à ressecção pulmonar por neoplasia

Health-related quality of life among patients with advanced cancer: an integrative review

Loci identified through genome-wide association studies and lung cancer risk: is there anything more?

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