Nuchal translucency: an ultrasound marker for fetal chromosomal abnormalities

Acácio, Gregório Lorenzo; Barini, Ricardo; Júnior, Walter Pinto; Ximenes, Renato Luís Silveira; Pettersen, Heverton; Faria, Marcos

doi:10.1590/s1516-31802001000100006

Cited by 5 publications

(9 citation statements)

References 34 publications

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“…Acacio et al . also found 69.5 and 75% sensitivity for aneuploidy and for trisomy 21, alternatively, at the same threshold of 2.5 mm 14 . To confirm the increase of fetal NT according to gestational age as stated by Snijder, 33 Hsu et al .…”

Section: Discussionmentioning

confidence: 73%

“…(1.9 mm) in Germany 25 and Acacio et al . (2.18 mm) in Brazil 14 . In fact, there were no clinical relevant effects in NT measurements by ethnic origin following Adekunle et al ., and Chen et al 19,26 .…”

Section: Discussionmentioning

confidence: 86%

“…measured fetal NT thickness in a sample of fetuses with a larger CRL mean than our study: 63.3 mm (range 45.0–84.0 mm) versus 55.4 mm (range 45.0–83.0 mm), 25 whereas, Acacio et al . investigated fetal NT thickness in high‐risk group women (whose average age were 35.8 years) 14 …”

Section: Discussionmentioning

confidence: 99%

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Fetal nuchal translucency thickness in different cut‐off points for aneuploidy screening in the south of Vietnam

Tomai

Schaaps

Foidart

2011

J of Obstet and Gynaecol

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Aims: The purpose of this study was to define the most suitable cut-off point for fetal nuchal translucency thickness in a screening program for aneuploidy and trisomy 21 in the south of Vietnam. Material & Methods: Two thousand and five hundred cases of singleton pregnancies were followed prospectively from the first trimester to the delivery. The rate of aneuploidy was calculated by seeking a relationship to increased fetal nuchal translucency thickness then calculating the sensitivity and specificity of different cut-off points in thickness measurement to find the most suitable point for screening. Results:The prevalence of fetal abnormality was 1.5% (95% CI 1.1-2.1), and 1.2% (95% CI 0.8-1.7) of aneuploidy cases found and the commonest was trisomy 21. A cut-off point at 2.4 mm showed the highest level of sensitivity and specificity for the detection of aneuploidy (65.5 and 95.7%) and trisomy 21 (75.0 and 95.1%), with a false-positive rate of 4.3 and 4.9%, respectively. Conclusion:Using a cut-off point of nuchal translucency at 2.4 mm has potential for aneuploidy and trisomy 21 screening in the south of Vietnam.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 86%

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Fetal nuchal translucency thickness in different cut‐off points for aneuploidy screening in the south of Vietnam

Tomai

Schaaps

Foidart

2011

J of Obstet and Gynaecol

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“…11 Various theories have been offered to explain the etiology for the nuchal fluid accumulation. 16 Possible mechanisms for increased NT are: cardiac failure in association with the abnormalities of heart and great arteries, venous congestion in the head and neck due to various reasons, altered composition of the extracellular matrix, abnormal or delayed development of the lymphatic system and also failure of the lymphatic drainage, fetal anemia or hypoproteinemia, congenital infection of the fetus etc. 17 Whatever the etiologies for fetal nuchal translucency are, measurement of nuchal translucency as a screening method has firmly taken place in practice.…”

Section: Discussionmentioning

confidence: 99%

Sensitivity and specificity of a prenatal screening method using the combination of maternal age and fetal nuchal translucency thickness for fetal aneuploidy: a clinical study in eastern India

Chaudhury

Mukherjee²

2016

Int J Reprod Contracept Obstet Gynecol

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“…An increased fetal NT thickness was defined at 3 cut-off points of 2.4 mm, 2.5 mm [8,9] and 95th percentile of CRL measurement [10,11] to evaluate and compare the detection rate of trisomy 21 and its false positive rate.…”

Section: Clinical Testmentioning

confidence: 99%

Evaluation of Trisomy 21 Screening by Fetal Nuchal Translucency Thickness, Maternal Age and Biochemical Serum in the South of Vietnam

Tomai¹,

Schaaps²

2012

Gynecol Obstet

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Aims: This study aimed to evaluate the most effective approach screening of trisomy 21 in the first trimester in Vietnam Method: A prospective study carried out during 1 year. All pregnancies screened the risk of trisomy 21 by association of the fetal nuchal translucency, maternal age and biochemical serum (free β-hCG and PAPP-A) as a combined test in the first trimester. The amniocentesis was used to diagnose trisomy 21. In each 4 approaches screening (the isolated maternal age, the maternal age and fetal NT thickness, maternal age and biochemistry, and combined test), the detection rate and false positive rate of trisomy 21 were calculated to find out the most effective screening method.Results: Followed up 2500 singleton pregnancies, the incidence of trisomy 21 was 0.6% (16/2500) (95%CI 0.4-1.0%). The absence of nasal bone and poly-malformation were the essential ultrasonographic findings of Down's syndrome. An increased fetal NT (≥ 2.4 mm) related significantly to this aneuploidy (OR=58.6, 95%CI 17.3-251, p < 0.0001). In comparison of 4 approaches screening, the most possibility of Down's syndrome detection was the combined test (87.5% of sensitivity for 2.6% of false positive rate). Conclusion:The combined test was effectively screening method for Down syndrome in Vietnamese pregnancies.

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Nuchal translucency: an ultrasound marker for fetal chromosomal abnormalities

Abstract: The measurement of nuchal translucency was found to be fairly accurate as an ultrasound marker for fetal abnormalities and measurements equal to or higher than 2.5 mm were the best fixed cutoff points.

Cited by 5 publications

References 34 publications

Fetal nuchal translucency thickness in different cut‐off points for aneuploidy screening in the south of Vietnam

Fetal nuchal translucency thickness in different cut‐off points for aneuploidy screening in the south of Vietnam

Sensitivity and specificity of a prenatal screening method using the combination of maternal age and fetal nuchal translucency thickness for fetal aneuploidy: a clinical study in eastern India

Evaluation of Trisomy 21 Screening by Fetal Nuchal Translucency Thickness, Maternal Age and Biochemical Serum in the South of Vietnam

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