Studies on Cross-linking of succinic acid with chitosan/collagen

Mitra, Tapas; Sailakshmi, G.; Gnanamani, A.; Mandal, Asit Baran

doi:10.1590/s1516-14392013005000059

Cited by 77 publications

(52 citation statements)

References 32 publications

(27 reference statements)

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“…These results suggest that the treatment with formic acid at 55 C increases the thermal stability of collagen fibers by itself and low concentrations of NDs (C1) do not interfere with this stabilization. The higher thermal stability of collagen fibers due to treatment with formic acid found in blank-2 with respect to the blank-1 sample is compatible with the hypothesis that formic acid favors the cross linking process [44]. The correlation between the thermal stability of the samples analyzed and the higher values of the 1660/1690 cm À1 ratio found in the FTIR study seems to support the correlation of this ratio with crosslinked structures, in agreement with the literature data [32e34].…”

Section: Thermogravimetric (Tg) Analysessupporting

confidence: 81%

“…The weak acid conditions of leather (pH < 3.5, isoelectric point of collagen) are mandatory in order to favorite the interaction of sulphonic groups of ADs with protonated amino groups of collagen [43]. We can hypothesize that in these conditions formic acid may act as a cross-linker for collagen, as well as succinic acid [44]. In the case of succinic acid the crosslinking is due to the ion interaction between the carboxylate groups and the protonated amine group of the collagen.…”

Section: Amide I Peak Fittingmentioning

confidence: 99%

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Study of the interaction between collagen and naturalized and commercial dyes by Fourier transform infrared spectroscopy and thermogravimetric analysis

Pellegrini

Corsi²,

Bonanni³

et al. 2015

Dyes and Pigments

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Section: Thermogravimetric (Tg) Analysessupporting

confidence: 81%

Section: Amide I Peak Fittingmentioning

confidence: 99%

Study of the interaction between collagen and naturalized and commercial dyes by Fourier transform infrared spectroscopy and thermogravimetric analysis

Pellegrini

Corsi²,

Bonanni³

et al. 2015

Dyes and Pigments

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“…The absorption in 1635 cm -1 and 1473 cm -1 correspond to the presence of asymmetric N-H (-NH 3 + ) band and asymmetric -COO-stretching respectively. Peaks at 1080 cm -1 , 860 cm -1 and 712 cm -1 in chitosan/gum arabic nanoparticles spectrum were similar to the native chitosan spectrum, which indicates no change in the main backbone of chitosan structure [28]. These resulted ionic interaction and multiple intermolecular hydrogen bonding between the -NH 2 groups of chitosan and consequently the crosslinking that resulted in the observed improved mechanical properties [11,28].…”

Section: Ftir Spectra Of the Synthesized Materialsmentioning

confidence: 74%

Synthesis and Characterization of Chitosan/Gum Arabic Nanoparticles for Bone Regeneration

Ibekwe¹,

Oyatogun²,

Esan³

et al. 2017

AJMSE

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Chitosan /gum arabic nanoparticles (C/G)have been prepared by ionic gelation method. This was with a view to enhance the mechanical properties and its application as bone graft scaffold. The cowry shells were washed, dried, pulverized and subsequently sieved with mesh No. 60, size 250 µm. It was deproteinized, Chitin was isolated from the synthesis by demineralising in 0.5 M Hydrochloric acid, and subsequently deacetylated by the addition of 40% (W/V) of Sodium hydroxide to synthesize chitosan. The raw chitosan was purified using 2% (v/v) acetic acid solution. The synthesized chitosan and gum arabic, a product of Acacia tree, were used to prepare chitosan/gum arabic nanoparticles by ionic gelation method. Mechanical characterization was carried out on the synthesized material using universal testing machine. Analysis of the chemical composition was carried out using Fourier transform infrared spectrometer (FTIR) and X-Ray fluorescence, (XRF). Furthermore, the morphology of the materials were studied using scanning electron microscopy, SEM and the dimension of the nanoparticles were characterized using transmission electron microscopy (TEM). Finally, an attempt was made to ascertain its suitability for bone regeneration. The FTIR spectra result confirmed that the nanoparticle was actually a derivative of chitosan by the observed shift in the peak 3462 to 3404cm- -1 and 712 cm -1 on C/G nanoparticles spectrum were similar to the native chitosan spectrum which shows that there was no change in the main backbone of chitosan structure. The scanning electron microscopy (SEM) study revealed chitosan as polymeric rods, while the chitosan /gum arabic nanoparticles in aggregate. The TEM was to confirm nanoparticles of average size of 200nm. The ultimate compressive strength was found to have increased by 78.21%, the Young Modulus by 54.4 % and percentage elongation by 7%. In overall assessment, mechanical properties of the chitosan/gum arabic nanoparticles were better than native chitosan. The study concluded that crosslinking of chitosan with gum arabic to form its nanoparticles derivative improved the mechanical properties of chitosan and consequently its application as a bone graft substitute for bone regeneration.

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“…42,44,45 Indeed, under our experimental conditions (3.5 < pH < 4.5), the amine groups of chitosan (p K a = 6.5) are protonated to form positively charged chains. 46 Simultaneously, the two carboxyl ends of MAc (p K a = 1.92) are fully ionized.…”

Section: Resultsmentioning

confidence: 81%

Assembly of Layered Monetite-Chitosan Nanocomposite and Its Transition to Organized Hydroxyapatite

Ruan

Liberman

Zhang

et al. 2016

ACS Biomater. Sci. Eng.

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Bioinspired synthesis of hierarchically structured calcium phosphate (CaP) material is a highly promising strategy for developing improved bone substitute materials. However, synthesis of CaP materials with outstanding mechanical properties still remains an ongoing challenge. Inspired by the formation of lamellar structure in nacre, we designed an organic matrix composed of chitosan and cis-butenediolic acid (maleic acid, MAc) that could assemble into a layered complex and further guide the mineralization of monetite crystals, resulting in the formation of organized and parallel arrays of monetite platelets with a brick-and-mortar structure. Using the layered monetite-chitosan composite as a precursor, we were able to synthesize hydroxyapatite (HAp) with multiscale hierarchically ordered structure via a topotactic phase transformation process. On the nanoscale, needlelike HAp crystallites assembled into organized bundles that aligned to form highly oriented plates on the microscale. On the large-scale level, these plates with different crystal orientations were stacked together to form a layered structure. The organized structures and composite feature yielded CaP materials with improved mechanical properties close to those of bone. Our study introduces a biomimetic approach that may be practical for the design of advanced, mechanically robust materials for biomedical applications.

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Studies on Cross-linking of succinic acid with chitosan/collagen

Cited by 77 publications

References 32 publications

Study of the interaction between collagen and naturalized and commercial dyes by Fourier transform infrared spectroscopy and thermogravimetric analysis

Study of the interaction between collagen and naturalized and commercial dyes by Fourier transform infrared spectroscopy and thermogravimetric analysis

Synthesis and Characterization of Chitosan/Gum Arabic Nanoparticles for Bone Regeneration

Assembly of Layered Monetite-Chitosan Nanocomposite and Its Transition to Organized Hydroxyapatite

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