The carcinogenic potential of cadmium in the palatal and gingival epithelium of rats: a morphologic and morphometric analysis

Motta, Ana Carolina Fragoso; Migliari, Dante Antônio; Gioso, Marco Antônio; Komesu, Marilena Chinali; Sala, Miguel Ángel; Lopes, Ruberval Armando

doi:10.1590/s1413-95962004000300006

Cited by 6 publications

(10 citation statements)

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“…Although in vitro studies have demonstrated the genotoxic potential of cadmium 16 , it does not seem to demonstrate a carcinogenic action on the oral mucosa during chronic exposure, shown by the current study among other previously published studies 10,11 who found a lack of dysplastic or neoplastic lesions (benign and malignant) in the oral epithelium. The cells of the keratinized epithelium and salivary glands undergo reduction and variation in nuclear shape by chronic exposure to cadmium 10 .…”

Section: Discussioncontrasting

confidence: 79%

“…Although some studies on the effects of cadmium have shown alteration of the oral epithelium and salivary glands by chronic cadmium exposure 10,11 as described above, in this study, despite exposure to cadmium having been greater than in anterior study 10 , which used 300 mg/L, we observed no change in the buccal mucosa, tongue or salivary glands.…”

Section: Discussioncontrasting

confidence: 62%

“…The cells of the keratinized epithelium and salivary glands undergo reduction and variation in nuclear shape by chronic exposure to cadmium 10 . Among the buccal cell changes presented in offspring of rats given cadmium during lactation, there was a reduction of cytoplasmic volume and an increase in the number of cells per mm 3 , as well as thinning of the keratinous layer 11 .…”

Section: Discussionmentioning

confidence: 99%

“…The cadmium chloride solution (400 mg/L; adapted to Motta et al 10 ) was administered to animals in the drinking water daily for six months 10 . The drinking water was refreshed three times a week to avoid pH change.…”

Section: Animal Protocolmentioning

confidence: 99%

“…A better understanding of the changes caused by cadmium in the body and possible ways to block these changes are important for preventing diseases related to this element. There are few studies in the literature that evaluate changes caused by cadmium in the oral mucosa and salivary glands 10,11 .…”

Section: Introductionmentioning

confidence: 99%

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Influence of water pH in oral changes caused by cadmium poisoning: an experimental study in rats

Martelli

Melo

Nai

et al. 2014

Rev. odontol. UNESP

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Objective: This study aims to evaluate the effect of the pH of drinking water in the oral changes caused by cadmium poisoning. Material and method: Ninety male Wister rats were divided into the following six groups: A - 15 rats were given cadmium chloride solution (400 mg/L) in drinking water with a neutral pH (pH 7.0); B - 15 rats received cadmium chloride solution (400 mg/L) in drinking water with an acidic pH (pH 5.0); C - 15 rats were treated with a cadmium chloride solution (400 mg/L) in drinking water with a basic pH (pH 8.0); D - 15 rats received drinking water with an acidic pH (pH 5.0); E - 15 rats were given drinking water with a basic pH (pH 8.0); F - 15 rats received water with a neutral pH (pH 7.0). All animals were sacrificed six months after the beginning of the experiment. A biopsy of the buccal mucosa, tongue and salivary gland of each animal was taken for microscopic analysis. Result: No changes were observed in the buccal mucosa, tongue mucosa or salivary glands in any of the groups. Conclusion: Drinking water that contains a high concentration of cadmium with differing pH levels demonstrated no damage to the oral mucosa and salivary glands of male Wistar rats.

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Section: Discussioncontrasting

confidence: 79%

Section: Discussioncontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Animal Protocolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Influence of water pH in oral changes caused by cadmium poisoning: an experimental study in rats

Martelli

Melo

Nai

et al. 2014

Rev. odontol. UNESP

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Respiratory tract cadmium-induced injuries—poisoning via intake and water pH could influence their genesis? An experimental study in rats

et al. 2017

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Study of the influence of the ph of water in the initiation of digestive tract injury in cadmium poisoning in rats

et al. 2015

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Cancer has genetic and environmental causes, one of which is the ingestion of heavy metals such as cadmium.ObjectiveTo evaluate the lesions caused by cadmium poisoning in the digestive tract and the possible effect of the drinking water pH in the initiation of these lesions.Methods90 male Wistar rats were used, divided into six groups (n = 15): A – received 400 mg/l cadmium chloride (CdCl2) in drinking water at a neutral pH of 7.0; B – received CdCl2 (400 mg/l) in drinking water at an acidic pH of 5.0; C – received CdCl2 (400 mg/l) in drinking water at a basic pH of 8.0; D – received water at an acidic pH of 5.0; E – received water at a basic pH of 8.0; and F – received water at a neutral pH of 7.0. Animals were euthanized after 6 months. Samples of the esophagus, stomach, small intestine and large intestine of each rat were removed for microscopic analysis.ResultsThere were no microscopic changes in either the esophagus or small and large intestines. Only cadmium-exposed animals showed mild dysplasia of the gastric mucosa (p = 0.012), regardless of the pH (p > 0.05).ConclusionCadmium exposure led to the formation of dysplastic lesions in the gastric glandular epithelium, regardless of the water pH.

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The carcinogenic potential of cadmium in the palatal and gingival epithelium of rats: a morphologic and morphometric analysis

Cited by 6 publications

References 0 publications

Influence of water pH in oral changes caused by cadmium poisoning: an experimental study in rats

Influence of water pH in oral changes caused by cadmium poisoning: an experimental study in rats

Respiratory tract cadmium-induced injuries—poisoning via intake and water pH could influence their genesis? An experimental study in rats

Study of the influence of the ph of water in the initiation of digestive tract injury in cadmium poisoning in rats

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