Respiratory tract cadmium-induced injuries—poisoning via intake and water pH could influence their genesis? An experimental study in rats

Nai, Gisele Alborghetti; Marin, Fernanda Freire; Queiroz, Lyara Meira Marinho; Estrella, Mariani Paulino Soriano

doi:10.1007/s00580-017-2474-7

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…The International Agency for Research on Cancer reported that inhalation exposure to Cd could lead to respiratory injury and lung cancer ( ATSDR, 2012 ). Besides, because the lung is a highly vascularized organ ( Nai et al., 2017 ), dietary Cd can have a high rate of accumulation in this organ also. These results suggest that Cd can accumulate in and result in toxicity to various organs, and the accumulation of Cd is the greatest in the kidney, followed by the liver, pancreas, and lung in laying hens.…”

Section: Discussionmentioning

confidence: 99%

Histological changes, lipid metabolism, and oxidative and endoplasmic reticulum stress in the liver of laying hens exposed to cadmium concentrations

Zhu

Bai

et al. 2020

Poultry Science

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The objective of this study was to determine the effects of cadmium ( Cd ) on histological changes, lipid metabolism, and oxidative and endoplasmic reticulum ( ER ) stress in the liver of layers. A total of 480 hens at 38 wk of age were randomly assigned in 5 groups that were fed a basal diet or basal diet supplemented with CdCl 2 2.5H 2 O at 7.5, 15, 30, and 60 mg Cd/kg feed for 9 wk. The results showed that accumulation of Cd was the greatest in the kidney, followed by the liver, pancreas, and lung. Diet contaminated with 30 mg Cd/kg induced antioxidant defenses accompanied by the increase of the activities of antioxidant enzymes in the liver, while dietary supplementation with 60 mg Cd/kg decreased the antioxidant levels significantly ( P < 0.05). Immunofluorescence assay showed Cd induced reactive oxygen species production and endoplasmic reticulum stress in hepatocytes. Exposure to 60 mg Cd/kg significantly upregulated the expression of cytochrome C, caspase 3, caspase 9, caspase 7, Grp78, and Chop ( P < 0.05). Histopathology and quantitative real-time PCR results presented periportal fibrosis, bile duct hyperplasia, and periportal inflammatory cell infiltration in the liver accompanied by upregulating the expression of tumor necrosis factor-α, IL-6 and IL-10 in the 30- or 60-mg Cd/kg groups. Oil Red O staining and RT-qPCR results showed dietary supplementation with 7.5, 15, and 30 mg Cd/kg promoted the synthesis of lipid droplets and upregulated the expression of fatty acid synthase, while dietary supplementation with 60 mg Cd/kg attenuated the synthesis of lipid droplets and downregulated the expression of acyl-CoA oxidase 1, carnitine palmitoyltransferase-1, and perixisome proliferation-activated receptor α ( P < 0.05). Besides, the expression of vitellogenin ( VTG ) II and microsomal triglyceride transfer protein were upregulated in the 7.5-mg Cd/kg group, and the expressions of apolipoprotein B, vitellogenin II, and apolipoprotein very-low-density lipoprotein-II were downregulated in the 30- and/or 60-mg Cd/kg groups ( P < 0.05). Conclusively, although low-dose Cd exposure promoted the synthesis of lipids and lipoproteins in the liver, the increase of Cd exposure could trigger liver injury through inducing oxidative and endoplasmic reticulum stress and negatively affect lipid metabolism and yolk formation in laying hens.

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Section: Discussionmentioning

confidence: 99%

Histological changes, lipid metabolism, and oxidative and endoplasmic reticulum stress in the liver of laying hens exposed to cadmium concentrations

Zhu

Bai

et al. 2020

Poultry Science

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Mitigating the Adverse Effects of Lead and Cadmium Heavy Metals-Induced Oxidative Stress by Phytogenic Compounds in Poultry

Ebrahimi¹,

Ebrahimi

Shakeri

2023

Poultry

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Environmental pollution has increased over the past few decades, posing serious risks to all biological systems, including the poultry sector. Oxidative stress in chickens caused by dietary, environmental, and pathological variables influences how well chickens perform as well as the quality of meat and eggs. Lead (Pb) and cadmium (Cd) are two examples of heavy metals that are harmful for chicken health. They can cause oxidative stress by increasing the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and blocking antioxidants from protecting cells from increased amounts of free radicals. The oxidative state of heavy metals, their interactions with endogenous antioxidants, and chemical processes all affect how hazardous they are to the body. Today, scientists have investigated and applied a variety of nutritional tactics to lessen the harmful effects of oxidative stress on animal health brought on by heavy metals. Researchers have recently become interested in the chemicals because of their chelating and growth-stimulating functions, as well as the antioxidant qualities of useful plant components. The deleterious consequences of oxidative stress induced by two heavy metals on chickens is discussed in this review, along with phytogenic use as a potential intervention strategy to lessen these effects and maintain the redox equilibrium in poultry.

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Respiratory tract cadmium-induced injuries—poisoning via intake and water pH could influence their genesis? An experimental study in rats

Cited by 2 publications

References 15 publications

Histological changes, lipid metabolism, and oxidative and endoplasmic reticulum stress in the liver of laying hens exposed to cadmium concentrations

Histological changes, lipid metabolism, and oxidative and endoplasmic reticulum stress in the liver of laying hens exposed to cadmium concentrations

Mitigating the Adverse Effects of Lead and Cadmium Heavy Metals-Induced Oxidative Stress by Phytogenic Compounds in Poultry

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