Analysis of the abortive and/or infertilizing activity of Stryphnodendron adstringens (Mart. Coville)

Bürger, Marilise Escobar; Ahlert, Neusa; Baldisserotto, Bernardo; Langeloh, Augusto; Schirmer, Baltazar; Foletto, Rejane

doi:10.1590/s1413-95961999000600003

Cited by 8 publications

(9 citation statements)

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“…The crude extract of stem bark was administered at high doses in mice and tested in liver mitochondria, showing signs of liver toxicity. Other studies have been conducted with other parts of the plant [25, 26]. Studies by De Sousa et al [27] and Costa et al [28] showed that S. adstringens had no genotoxic effects in Drosophila melanogaster or micronuclei (bone marrow) and Artemia salina tests in mice, respectively.…”

Section: Introductionmentioning

confidence: 99%

Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark ofStryphnodendron adstringens(Barbatimão) in Rodents

Costa

Mello

Kaneshima

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Stryphnodendron adstringens has a high tannin content and is used as an antiseptic and antimicrobial and in the treatment of leucorrhea, gonorrhea, wound healing, and gastritis. The present study evaluated the toxic effects of the heptamer prodelphinidin (F2) from the stem bark of S. adstringens in rodents. In the acute toxicity test, the mice that received oral doses exhibited reversible effects, with an LD50 of 3.015 mg · kg−1. In the chronic toxicity test at 90 days, Wistar rats were treated with different doses of F2 (10, 100, and 200 mg · kg−1). In the biochemical, hematological, and histopathological examinations and open-field test, the different dose groups did not exhibit significant differences compared with controls. The present results indicate that F2 from the stem bark of S. adstringens caused no toxicity with acute and chronic oral treatment in rodents at the doses administered.

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Section: Introductionmentioning

confidence: 99%

Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark ofStryphnodendron adstringens(Barbatimão) in Rodents

Costa

Mello

Kaneshima

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…Decreased live fetuses and uterus weight without affecting implantation Burger et al, 1999 a Incomplete information because the complete original study could not be retrieved; GD: gestational day; n: number of animals per group. Luiz Fernando Verissimo et al for pregnant women, usually aware and afraid of the risks that synthetic drugs may have in their pregnancy and progeny, well designed studies evaluating female reproductive and/or developmental toxicity of these herbs urge if they may become phytomedicines.…”

Section: Discussionmentioning

confidence: 99%

Herbs of interest to the Brazilian Federal Government: female reproductive and developmental toxicity studies

Veríssimo¹,

Bacchi²,

Zaminelli³

et al. 2011

Rev. bras. farmacogn.

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Abstract:In 2009 the Brazilian Ministry of Health published a document named RENISUS that lists 71 herbs traditionally used in Brazil that could result in phytomedicines to be dispensed by the governmental health care program. This manuscript reviews female reproductive and/or developmental toxicity information of these herbs. More than half (35) of the herbs lack information regarding female reproductive and/or developmental effects. From the fourteen herbs used traditionally to disturb female reproduction, five present experimental data corroborating their actions as abortifacients (Maytenus ilicifolia, Momordica charantia, Plectranthus barbatus, Ruta graveolens) or labour facilitator (Bidens pilosa). For 23 of the herbs evaluated experimentally for any type of female reproductive endpoint, only a single study was retrieved and at least twelve of these studies were conducted with a single dose. This scenario suggests that the scientific power of the published information is very low and that a scientifically-based risk/benefit analysis about the use of these herbs during pregnancy is not possible. Considering the appeal that phytomedicines have for pregnant women, usually aware and afraid of the risks that synthetic drugs may have in their pregnancy and progeny, well designed studies evaluating reproductive and/or developmental toxicity of these herbs urge.

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“…The Combretaceae family comprises 20 genera and more than 600 species (GARCEZ et al, 2003). Combretum and Terminalia are the most speciesrich genera, with over 200 species each (KATERERE et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Tannins and terpenes are also present in plants from this genus. These chemical compounds were isolated from green leaves of Buchenavia oxicarpa (HERNES;HEDGES, 2004;PEÑUELAS et al, 1996). Numerous reports are available about the influence of tannins on rats, causing systemic effects such as metabolism and blood disturbances (HERNES;HEDGES, 2004;SALUNKHE et al, 1990), and reproductive toxicity (BURGÜER et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

“…These chemical compounds were isolated from green leaves of Buchenavia oxicarpa (HERNES;HEDGES, 2004;PEÑUELAS et al, 1996). Numerous reports are available about the influence of tannins on rats, causing systemic effects such as metabolism and blood disturbances (HERNES;HEDGES, 2004;SALUNKHE et al, 1990), and reproductive toxicity (BURGÜER et al, 1999). Terpenes produce several reproductive effects such as developmental toxicity and estrous cycle irregularity (DELGADO et al, 1993;RASIER et al, 2006;SATO et al, 2003;WASUNTARAWAT et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Buchenavia tomentosa consumption on female rats and their offspring

Nunes

Paiva

Ramos

et al. 2010

Acta Sci. Biol. Sci.

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ABSTRACT. Buchenavia tomentosaEichler is a common plant in Brazilian cerrado. Fruits of this plant are employed in human feeding and folk medicine. Cattle producers affirm that consumption of the fruits cause abortion in cows, and even death. Considering that the plant may be consumed by pregnant women and animals, the present study was undertaken to evaluate the possible toxic effects of the ingestion of B. tomentosa fruit (10% added to the diet), from the first to the twenty-first days of gestation, on reproductive parameters and on physical and neurobehavioral development of rats offspring. An increase in food consumption at pregnancy days 11 and 17, and weight increase at day 17 of pregnancy were observed. Besides that, we verified an increase in weight of male offspring on post natal day 1. Other parameters were not affected by plant consumption. These results indicate that the consumption of B. tomentosa at 10% during pregnancy cause slight toxicological effects. The changes verified in the present study indicate toxic action of the fruit possibly induced by flavonoids with hormonal action; however, further studies must be accomplished to corroborate this hypothesis.Key words: teratology, developmental toxicology, reproductive toxicology,toxic plant. RESUMO. Efeitos do consumo de Buchenavia tomentosa em ratas e em suas proles.Buchenavia tomentosa Eichler é uma planta típica do cerrado brasileiro. Os frutos desta planta são empregados na alimentação humana e medicina popular. Criadores de bovinos afirmam que o consumo desta planta produz aborto em vacas bem como a morte destes animais. Uma vez que a planta pode ser consumida pelo homem e animais, em idade fértil e inclusive gestantes, o presente estudo avaliou os possíveis efeitos tóxicos da ingestão de dieta com 10% de frutos de B. tomentosa do primeiro ao vigésimo primeiro dia de gestação sobre os parâmetros reprodutivos e sobre o desenvolvimento físico e neurocomportamental das ninhadas de ratos. Foram observadas elevações no consumo de alimentos nos dias 11 e 17 de gestação e no peso ao dia 17 de gestação. Aumento do peso dos filhotes machos foi verificado no primeiro dia após o nascimento. Outros parâmetros não foram afetados pelo consumo da planta. Estes resultados indicam que a ingestão, durante a gestação, de uma dieta acrescida com 10% de B. tomentosa causa efeitos tóxicos leves. As alterações verificadas no presente estudo indicam ação tóxica do fruto possivelmente induzidos por flavonoides de ação hormonal; no entanto, estudos detalhados devem ser conduzidos para garantir esta hipótese. Palavra-chave: teratologia, toxicologia do desenvolvimento, toxicologia da reprodução, planta tóxica.

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Analysis of the abortive and/or infertilizing activity of Stryphnodendron adstringens (Mart. Coville)

Cited by 8 publications

References 1 publication

Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark ofStryphnodendron adstringens(Barbatimão) in Rodents

Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark ofStryphnodendron adstringens(Barbatimão) in Rodents

Herbs of interest to the Brazilian Federal Government: female reproductive and developmental toxicity studies

Effects of Buchenavia tomentosa consumption on female rats and their offspring

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