Molecular detection of cytomegalovirus, herpes simplex virus 2, human papillomavirus 16-18 in Turkish pregnants

Dinç, Bedia; Bozdayı, Gülendam; Bırı, Aydan; Kalkancı, Ayşe; Doğan, Bora; Bozkurt, Nuray; Rota, Seyyal

doi:10.1590/s1413-86702010000600005

Cited by 5 publications

(6 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The prevalence of HSV demonstrated in this study was higher than that previously described in cervical samples from other countries. Several studies investigated asymptomatic HSV shedding from the uterine cervix by PCR -the lowest rates (approximately 3%) were observed in Turkey and Sweden and the highest in Argentina (21.5%) and Brazil (26%) (6)(7)(8)(9). It was interesting that most cases in our study were HSV1 positive and only one was HSV2 positive.…”

Section: Discussionmentioning

confidence: 53%

Cervical Viral Infections among Asymptomatic Bulgarian Women

Staykova¹,

Belovska²,

Murad³

et al. 2016

Cent Eur J Public Health

View full text Add to dashboard Cite

SUMMARYAim: Although sexually transmitted viral infections are significant and increasing public health concern, little is known about their prevalence among Bulgarian women. The aim of this study was to investigate cervical viral infections in asymptomatic women.Methods: The study group included 52 randomly selected asymptomatic female volunteers from Bulgarian border town Kardzhali. Cervical specimens were tested by real-time PCR for human papillomaviruses (HPV), herpes simplex virus (HSV) types 1 and 2, cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human immunodeficiency virus (HIV).Results: The investigation demonstrated a high rate (61.5%) of infection with one or more viruses of uterine cervix of participating women considered at low risk. The most prevalent was HPV, found in 32.7% of all women. The genotyping of high-risk (HR) HPV positive specimens showed that HPV16 was the most prevalent HR type. HSV prevalence (30.8%) was almost as high as that of HPV and most women were HSV1 infected. 9.6% and 5.8% of all specimens were positive for EBV and CMV, respectively.Conclusions: Our results indicate that women from Kardzhali region, involved in this study, might be at risk for development of genital tract pathology, including cervical cancer, and for transmission of virus infection sexually and perinatally.

show abstract

Section: Discussionmentioning

confidence: 53%

Cervical Viral Infections among Asymptomatic Bulgarian Women

Staykova¹,

Belovska²,

Murad³

et al. 2016

Cent Eur J Public Health

View full text Add to dashboard Cite

show abstract

“…Literature has shown that the prevalence of CMV infection in cervical samples varies significantly: Dinc et al [] showed a prevalence of 1.4%; Leung et al [] found a prevalence of 7.4%; Broccolo et al [] found a prevalence of 66.0%; and Szostek et al [] found a prevalence of 52.0%. This study reveals a significantly lower prevalence of CMV infection (4.5%) when compared with other studies and in addition, this study showed that CMV was only found in women <30 years and >60 years old.…”

Section: Discussionmentioning

confidence: 99%

Characterization of cytomegalovirus and epstein‐barr virus infection in cervical lesions in Portugal

Marinho‐Dias

Ribeiro

Monteiro

et al. 2013

Journal of Medical Virology

View full text Add to dashboard Cite

Infection by high-risk types of human papillomavirus (HPV) is considered necessary but not sufficient for the development of cervical cancer. Previous studies suggested that cytomegalovirus (CMV) and Epstein-barr virus (EBV) could be co-factors of HPV-associated carcinogenesis. The aim of this study was to characterize the prevalence of CMV and EBV and evaluate its association with the development cervical lesions in Portugal. The prevalence of CMV and EBV infections was determined by real-time PCR in 89 cervical samples from women with different histological lesions, who attended the Portuguese Institute of Oncology of Porto. This study revealed an overall prevalence of 4.5% for CMV and 10.1% for EBV. Age-stratified analysis revealed that CMV infection was present in individuals <30 and >60 years old, while EBV infection was present in all age groups. CMV was detected in 9.5% of low-grade lesions and in 22.2% of in situ/invasive carcinomas, while EBV infection was found in all different types of lesions. In addition, data revealed that CMV infection was associated with an increased risk of in situ/invasive carcinoma development (OR=1.28; P=0.035). The study reveals a low prevalence for both viruses; nevertheless, these results are important for knowledge on the shedding of EBV and CMV in cervical samples.

show abstract

“…A large spectrum of cells of the fetus is infected by CMV. The major target fetal organs for CMV infection are the lungs, pancreas, kidneys and the liver but comparing with these organs, CMV DNA level determined in uterine tissue and cervical smear is higher (Dinc et al, 2010).…”

Section: Materials and Methods Sample Collectionmentioning

confidence: 99%

Serological and Molecular Comparison Study for Diagnosis of Cytomegalovirus Infection in aborted Pregnant Women in Iraq

Al-Taie¹,

Abdullah²,

Al-Attar³

2018

RJS

View full text Add to dashboard Cite

This study was conducted to investigate the Cytomegalovirus (CMV) infections of pregnant women. The samples were collected from Mosul and Baghdad hospitals in Iraq for two years and the tested women within the age category of under 20 to above 39 years. One thousand five hundred samples were taken as serum, to use in ELISA (IgM, IgG). EDTA blood, Heparin blood and cervical swabs were used in molecular tests. Three hundred positive samples demonstrating the presence of IgM and IgG antibodies using ELISA test. IgM antibodies were positive in 146 (48.7%) CMV, IgG antibodies were positive in 189 (63%) for CMV. DNA was extracted and Real-Time PCR indicates positive in only four samples (1.3%) in CMV from all 300 positive samples in ELISA tests.

show abstract

Molecular detection of cytomegalovirus, herpes simplex virus 2, human papillomavirus 16-18 in Turkish pregnants

Cited by 5 publications

References 19 publications

Cervical Viral Infections among Asymptomatic Bulgarian Women

Cervical Viral Infections among Asymptomatic Bulgarian Women

Characterization of cytomegalovirus and epstein‐barr virus infection in cervical lesions in Portugal

Serological and Molecular Comparison Study for Diagnosis of Cytomegalovirus Infection in aborted Pregnant Women in Iraq

Contact Info

Product

Resources

About