Risk factors for infection by extended-spectrum beta-lactamase producing Klebsiella pneumoniae in a tertiary hospital in Salvador, Brazil

Silva, Nanci; Oliveira, Márcio Moysés de; Bandeira, António; Brites, Carlos

doi:10.1590/s1413-86702006000300007

Cited by 26 publications

(19 citation statements)

References 13 publications

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“…pneumoniae, E. coli, others2979NDTanzania [36]2007UniversityBothChildren, adultsUrine, pus, blood d PCR-SequencingK. pneumoniae, E. coli, P. aeruginosa, others22735VIM (12.3 %), OXA-48 (4.9 %), KPC (3.5 %), NDM (3.1 %)Tanzania [57]2012UniversityBothChildren, adultsWoundDDSTPseudomonas spp, Proteus spp, K. pneumoniae, E. coli11735NDTanzania [58]2011UniversityBothChildren, adultsWoundDDSTK. pneumoniae, E. coli, others2471NDTanzania [59]2009UniversityBothChildrenBloodDDSTK.…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis of proportion estimates of Extended-Spectrum-Beta-Lactamase-producing Enterobacteriaceae in East Africa hospitals

Sonda

Kumburu

Zwetselaar

et al. 2016

Antimicrob Resist Infect Control

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BackgroundA high proportion of Extended-Spectrum-Beta-Lactamase (ESBL) producing Enterobacteriaceae is causing common infections in all regions of the world. The burden of antibiotic resistance due to ESBL in East Africa is large but information is scarce and thus it is unclear how big the problem really is. To gain insight into the magnitude and molecular epidemiology of ESBL-producing Enterobacteriaceae in East Africa a literature search was performed in PubMed on 31 July 2015 to retrieve articles with relevant information on ESBL.Methods and resultsMeta-analysis was performed to determine overall proportion estimate of ESBL-producing Enterobacteriaceae. A total of 4076 bacterial isolates were included in the analysis. The overall pooled proportion of ESBL-producing Enterobacteriaceae among included surveys done in East African hospitals was found to be 0.42 (95 % CI: 0.34–0.50). Heterogeneity (I2) between countries’ proportions in ESBL was significantly high (96.95 % and p < 0.001). The frequently detected genes encoding ESBL were CTX-M, TEM, SHV and OXA while the most infrequent reported genes were KPC and NDM.ConclusionThe available studies show a very wide variation in resistance due to ESBL between countries. This highlights a need for active surveillance systems which can help understand the actual epidemiology of ESBL, aid in formulating national or regional guidelines for proper screening of ESBL, and support developing standardized approaches for managing patients colonized with ESBL.Electronic supplementary materialThe online version of this article (doi:10.1186/s13756-016-0117-4) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Meta-analysis of proportion estimates of Extended-Spectrum-Beta-Lactamase-producing Enterobacteriaceae in East Africa hospitals

Sonda

Kumburu

Zwetselaar

et al. 2016

Antimicrob Resist Infect Control

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“…The worldwide spread of ESBL producing E. coli has been strikingly rapid, especially in communities, and is an important case of invasive infection (16, 17). Age over 60, previous antibiotic treatment, long hospitalization, and diabetes were found to be the factors associated with ESBL (18). Identification of betalactamase is essential for a reliable epidemiological investigation of antimicrobial resistance.…”

Section: Discussionmentioning

confidence: 99%

Detection of ctx-M gene in ESBL-producing E. coli strains isolated from urinary tract infection in Semnan, Iran

Tabar¹,

Mirkalantari²,

Amoli³

2016

Electron physician

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IntroductionThe incidence of urinary tract infections caused by Extended-Spectrum Beta Lactamase (ESBL) producing Escherichia coli (E. coli) strains due to long term and overuse of broad-spectrum cephalosporine is on the rise. CTX beta-lactamase type, a broad-spectrum beta-lactamase, has been expanding in many countries. The ctx gene is harbored on a plasmid that is spread between Enterobacteriaceae family, especially in E. coli. The aim of this study was to determine the pattern of antimicrobial resistance and investigate the prevalent ESBL phenotype and the ctx-M gene in E. coli isolated from patients with urinary tract infections (UTI) in Semnan.MethodsA cross sectional study was performed on 109 strains of E. coli isolated from the urine culture of patient suffering from a UTI referred to Shafa hospital (Semnan, Iran) during March–July 2015. Antimicrobial susceptibility testing was applied and the prevalence of the ESBL phenotype was confirmed using combination disk. PCR methods were completed for amplification of the bla ctx gene. Data were analyzed using SPSS version 18 software.ResultsOne hundred ninety samples (4.16%) were identified as E. coli. Twenty one (26.6%) of E. coli were ESBL positive and 73.4% were ESBL negative. There was 100% susceptibility to imipeneme. Twenty (68.97%) out of 29 isolates were positive for the ctx-M gene, as detected by PCR.ConclusionIn urinary tract infections, antibiotic treatment was experimental and detailed information regarding the sensitivity of bacteria in the area can be useful to achieve the best treatment.

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“…The main risk factors for colonization or infection with ESBLproducing bacteria are previous antibiotic use 2,5 , presence of invasive devices such as catheters 23,24 , prolonged hospital stay 25,26 , previous hospitalization 17 , delay in appropriate treatment, presence of ulcers 5,23 and ICU stay 2,17 . The highest incidence of ESBL-producing bacteria was observed in ICUs, which can be explained by the emergent character of this unit.…”

Section: Discussionmentioning

confidence: 99%

Nosocomial infection and characterization of extended-spectrum β-lactamases-producing Enterobacteriaceae in Northeast Brazil

Abreu

Marques

Monteiro-Neto

et al. 2011

Rev. Soc. Bras. Med. Trop.

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Introduction: Extended spectrum β-lactamases (ESBLs) are enzymes that degrade β-lactam antibiotics and have been reported to be an important cause of nosocomial infection in worldwide. Methods: During 2009, 659 enterobacteria strains were isolated from different clinical specimens and tested for ESBL production. The disk approximation test, combined disk method and addition of clavulanic acid were used for phenotypic detection of the ESBL-producing strains and PCR for detection of the bla TEM and bla CTX-M genes. Results: Among the isolates, 125 were ESBL producers. The bla CTX-M and bla TEM genes were detected in 90.4% and 75% of the strains, respectively. Most strains were isolated from urine. Klebsiella pneumoniae was the most prevalent organism. Microorganisms presented high resistance to the antibiotics. Conclusions: These results support the need for extending ESBL detection methods to different pathogens of the Enterobacteriaceae family because these methods are only currently standardized by the CLSI for Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca and Proteus mirabilis. Carbapenems were the antibiotic class of choice for the treatment of infections caused by ESBL-producing Enterobacteriaceae.

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Risk factors for infection by extended-spectrum beta-lactamase producing Klebsiella pneumoniae in a tertiary hospital in Salvador, Brazil

Abstract: Our findings suggest that the use of antibiotics or underlying disease that increases the chance of antibiotic are the main risk factors for ESBL-Kp infections. Programs focusing on rational use of antibiotics are mandatory for prevention and control of such infections.

Cited by 26 publications

References 13 publications

Meta-analysis of proportion estimates of Extended-Spectrum-Beta-Lactamase-producing Enterobacteriaceae in East Africa hospitals

Meta-analysis of proportion estimates of Extended-Spectrum-Beta-Lactamase-producing Enterobacteriaceae in East Africa hospitals

Detection of ctx-M gene in ESBL-producing E. coli strains isolated from urinary tract infection in Semnan, Iran

Nosocomial infection and characterization of extended-spectrum β-lactamases-producing Enterobacteriaceae in Northeast Brazil

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