Citocinas pró-inflamatórias e dor

Kraychete, Durval Campos; Calasans, Maria Thais De Andrade; Valente, Camila Motta Leal

doi:10.1590/s0482-50042006000300007

Cited by 21 publications

(22 citation statements)

References 61 publications

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“…In these cases, restoration of function is reduced if not impossible, and pain can be felt from nonnociceptive stimulus [12]. This can happen on cesarean section, a surgery that is frequently performed in women during fertile age [13].…”

Section: Introductionmentioning

confidence: 99%

Predictors for Moderate to Severe Acute Postoperative Pain after Cesarean Section

Borges

Pereira

Moura

et al. 2016

Pain Research and Management

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Background. Moderate to severe postoperative pain affects performance of daily activities and it contributes to persistent postoperative pain. In patients submitted to cesarean section, this pain can also interfere with women's ability to care for their babies, to effectively breastfeed, and to satisfactorily interact with their children. Factors influencing the pain perception during the immediate postoperative period have not been widely pursued. Objective. To investigate the incidence and predicting factors of postoperative pain after cesarean section. Methods. A prospective longitudinal study with 1,062 women submitted to cesarean section. We collected sociodemographic, clinical, surgical, and health behavior data. We used the 11-point Numerical Pain and the Hospital Anxiety and Depression Scales. We performed logistic analysis to identify predictors of moderate to severe postoperative pain. Results. The incidence of moderate-severe postoperative pain was 78.4% (CI: 95%: 75.9%–80.8%). The preoperative anxiety (OR = 1.60; CI 95%: 1.22–2.30) and intrathecal morphine with fentanyl (OR = 0,23; CI 95%: 0.08–0.66) were significantly associated with moderate-severe postoperative pain report. Conclusion. The preoperative anxiety increases the risk of moderate-severe postoperative pain in women submitted to cesarean section. The intrathecal morphine with fentanyl added to bupivacaine was a protective factor against this pain.

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Section: Introductionmentioning

confidence: 99%

Predictors for Moderate to Severe Acute Postoperative Pain after Cesarean Section

Borges

Pereira

Moura

et al. 2016

Pain Research and Management

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“…IL-1β is possibly involved in the inhibition of the ability of glial cells to remove glutamate molecules from the synaptic cleft, adding to neuronal excitability of tumor necrosis factor receptor 1. 4 A significant increase in the expression of these inflammatory cytokines in tendinitis leads to fibroplast proliferation and therefore to tendon degeneration. 5 Iontophoresis has been studied for over a century due to its ability to release medicinal drugs through the transcutaneous pathway based on low-frequency electrical currents.…”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticles and diclofenac diethylammonium administered by iontophoresis reduce inflammatory cytokines expression in Achilles tendinitis

Venancio¹,

Possato²,

Zeferino³

et al. 2012

IJN

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Introduction Tendinitis affects a substantial number of people in several occupations involving repetitive work or direct trauma. Iontophoresis is a therapeutic alternative used in the treatment of injury during the inflammatory phase. In recent years, gold nanoparticles (GNP) have been studied due to their therapeutic anti-inflammatory capacity and as an alternative to the transport of several proteins. Purpose This study evaluates the therapeutic effects of iontophoresis using GNPs and diclofenac diethylammonium on inflammatory parameters in rats challenged with traumatic tendinitis. Methods Wistar rats were divided in three treatment groups (n = 15): (1) iontophoresis + diclofenac diethylammonium; (2) iontophoresis + GNP; and (3) iontophoresis + diclofenac diethylammonium + GNP. External control was formed by challenged tendons without treatment (n = 15). Iontophoresis was administered using 0.3 mA direct current on 1.5 cm 2 electrodes. Results The levels of both inflammatory cytokines were significantly higher in untreated challenged rats, when compared with the control (5.398 ± 234 for interleukin 1 beta and 6.411 ± 432 for tumor necrosis factor alpha), which confirms the occurrence of an inflammatory stage in injury ( P < 0.05). A significant decrease was observed in expression of cytokines interleukin 1 beta in the three treatment groups, in comparison with untreated challenged tendons, although, in the group treated with diclofenac and GNP, results were similar to the control (1.732 ± 239) ( P < 0.05). Concerning tumor necrosis factor alpha, only the group treated with the association diclofenac and GNPs presented decreased levels, compared with the control (3.221 ± 369) ( P < 0.05). Conclusion The results show the efficacy of drug administration using direct current to treat tendinitis in an animal model, and the potential anti-inflammatory, carrier, and enhancing effects of GNPs in iontophoresis.

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“…Cytokines, low molecular weight glycoproteins secreted by different cells of the body, play an important role in this process as inflammatory mediators (biomarkers) that control the duration and intensity of inflammation, capable of acting at or near the sites where they are produced, or being released into the bloodstream [14]. Chronic inflammation, which persists over longer periods, seems to have a harmful effect on the body [8,12].…”

Section: Introductionmentioning

confidence: 99%

Association between inflammatory mediators, grip strength and mobility in community-dwelling elderly

et al. 2018

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Introduction: Aging is associated with loss of muscle mass, immunosenescence and increased production of inflammatory mediators, high levels being predictors of a decline in functional capacity in the elderly. Objective: To assess the association between inflammatory mediators, interleukin 6 (IL-6) and C-reactive protein (CRP) and functional capacity in the elderly. Methods: Cross-sectional study with 308 community-dwelling elderly. The study was approved by the Research Ethics Committee, under protocol number 067/2010. Grip strength (GS) was measured using a JAMAR® dynamometer and functional capacity by the Timed Up and Go (TUG) test. Blood tests were performed and serum levels of C-reactive protein and interleukin 6 assessed. Spearman’s coefficient was applied to analyze the correlation between variables and the Mann-Whitney for intergroup comparison. Significance was set at 0.05. Results: There was no significant correlation between GS, the TUG and inflammatory mediators (CRP and IL-6). However, by adjusting for variables such as age, sex and muscle mass, a significant and inverse correlation (p = 0.023) was observed between GS and CPR. Conclusion: Elderly subjects with low C-reactive protein levels performed better in the grip strength test. It is important to investigate the adverse effects on functional capacity that can be influenced by inflammatory cytokines in the elderly during aging.

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Citocinas pró-inflamatórias e dor

Cited by 21 publications

References 61 publications

Predictors for Moderate to Severe Acute Postoperative Pain after Cesarean Section

Predictors for Moderate to Severe Acute Postoperative Pain after Cesarean Section

Gold nanoparticles and diclofenac diethylammonium administered by iontophoresis reduce inflammatory cytokines expression in Achilles tendinitis

Association between inflammatory mediators, grip strength and mobility in community-dwelling elderly

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