Síndrome de extravasamento capilar sistêmico

Bressan, Aline Lopes; Gripp, Alexandre Carlos; Oliveira, Elisa Fontenelle de; Silva, Roberto Souto da

doi:10.1590/s0365-05962011000300031

Cited by 10 publications

(2 citation statements)

References 9 publications

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“…[ 11 ] Levels of angiogenic factors like transforming growth factor beta (TGF-β), platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF) have been found to be raised in psoriasis, which can significantly alter the morphology and physiology of the microcirculation, and may have a role in nailfold capillary changes. [ 5 12 13 ] Zaric et al . [ 7 ] have observed sluggishness of blood flow in the nailfold capillaries of psoriasis patients.…”

Section: Discussionmentioning

confidence: 99%

A Cross-Sectional Study of Nailfold Capillary Changes in Psoriasis

Santhosh

Riyaz

Bagde

et al. 2021

Indian Dermatology Online Journal

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Background: Microcirculation in the skin of psoriasis patients significantly differs from unaffected individuals. Vascular changes precede skin lesions and occur even in nonlesional skin. Aims: The primary aim of this work was to study the nailfold capillary changes in psoriasis patients, and to compare it with that of controls. The secondary aim of this work was to compare the nailfold capillary changes in psoriasis patients with and without nail changes. Methods: A comparative cross-sectional study of 40 psoriasis patients and 40 age and sex-matched controls analyzed the capillaries of the proximal nailfold of all fingers using a dermoscope. The mean capillary loop density/mm, tortuous capillaries, capillary hemorrhages, and avascular areas were assessed. Results: The mean nailfold capillary loop density in psoriasis (6.98 ± 0.54 per mm) was significantly less than that in controls (8.01 ± 0.61 per mm) ( P < 0.001). Avascular areas in the nailfold of psoriasis patients (55%) were significantly more than the same in controls (22.5%) ( P = 0.003). Of 40 psoriasis patients, 26 had nail psoriasis. Of this, 19 (73%) had avascular areas ( P = 0.002). No significant association of nailfold capillary density or avascular areas with disease duration or severity was noted. An increase in tortuous capillaries and nailfold hemorrhages noted in psoriasis was not significant. Limitations: Small sample size, not having participants with psoriatic arthropathy, and lack of information on capillary diameter and capillary changes in hyponychium were the limitations. Conclusion: The reduced mean capillary loop density, and higher frequency of avascular areas noted in cases compared to controls, points to a pathogenic role for microvascular damage in psoriasis. Whether the lack of association of these changes with disease duration and severity suggests the possibility of these being early disease markers for psoriasis, needs further analysis in larger prospective studies.

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Section: Discussionmentioning

confidence: 99%

A Cross-Sectional Study of Nailfold Capillary Changes in Psoriasis

Santhosh

Riyaz

Bagde

et al. 2021

Indian Dermatology Online Journal

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“…Systemic capillary leak syndrome is the complication that more frequently results in death, and often occurs from pustular and erythrodermic forms, the most unstable ones. 1 , 2 In systemic capillary leak syndrome the endothelium is deeply involved with increased VEGF and ICAM-1, resulting in thermoregulation disorder, dehydration, tachycardia, pericardial and pulmonary effusion, respiratory distress in adults and even death. This literature review assessed the relevance of these molecules and their links with complications.…”

Section: Introductionmentioning

confidence: 99%

How relevant are vascular endothelial growth factor and intercellular adhesion molecule in the systemic capillary leak syndrome of psoriasis?

Bressan

Pereira²,

Medeiros

et al. 2017

An. Bras. Dermatol.

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Psoriasis is a chronic disease, characterized by erythematous scaly lesions, presented in eight different forms: plaques, guttate, pustular, erythrodermic, inverse, nail and scalp psoriasis, and psoriatic arthritis. Its development depends on genetic factors, external stimulus and immune response alteration.1 Proinflammatory cytokines such as TNF-alpha, IL-12 and 23 may also be involved. In the worst cases, systemic complications linked to endothelial alterations may occur. A literature review was conducted for a better understanding of what roles VEGF (vascular endothelial growth factor) and ICAM-1 (intercellular adhesion molecule) have, among other cytokines, in systemic capillary leak syndrome, involved in erythrodermic and pustular psoriasis, the most unstable forms of the disease.

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Retinoids

Azulay¹,

Vendramini²

2017

Clinical Approaches and Procedures in Cosmetic Dermatology

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Síndrome de extravasamento capilar sistêmico

Cited by 10 publications

References 9 publications

A Cross-Sectional Study of Nailfold Capillary Changes in Psoriasis

A Cross-Sectional Study of Nailfold Capillary Changes in Psoriasis

How relevant are vascular endothelial growth factor and intercellular adhesion molecule in the systemic capillary leak syndrome of psoriasis?

Retinoids

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