Síndrome do ovário policístico: abordagem dermatológica

Moura, Heloisa Helena G.; Costa, Dailana Louvain Marinho; Bagatin, Ediléia; Sodré, Celso Tavares; Manela-Azulay, Mônica

doi:10.1590/s0365-05962011000100015

Cited by 44 publications

(34 citation statements)

References 39 publications

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“…In addition, as a result of the IR, the pancreas produces much more insulin than normal. This condition, called hyperinsulinemia, accelerates lipogenesis with increased production of free fatty acids, reduces levels of sex hormone binding globulin (SHBG), increases luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels, and, finally, leads to an increase in the production of ovarian androgens and also in their biologically active portion potentially leading to hyperandrogenism ( Figure 2 ) [ 6 , 7 ]. Hyperandrogenism, a common endocrine disorder of women of reproductive age with a prevalence of 5–10%, comprises a heterogeneous group of conditions that exhibit a common phenotype.…”

Section: Insulin Insulin Resistance and Skinmentioning

confidence: 99%

Insulin Resistance and Skin Diseases

Napolitano

Megna

Monfrecola

2015

The Scientific World Journal

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In medical practice, almost every clinician may encounter patients with skin disease. However, it is not always easy for physicians of all specialties to face the daily task of determining the nature and clinical implication of dermatologic manifestations. Are they confined to the skin, representing a pure dermatologic event? Or are they also markers of internal conditions relating to the patient's overall health? In this review, we will discuss the principal cutaneous conditions which have been linked to metabolic alterations. Particularly, since insulin has an important role in homeostasis and physiology of the skin, we will focus on the relationships between insulin resistance (IR) and skin diseases, analyzing strongly IR-associated conditions such as acanthosis nigricans, acne, and psoriasis, without neglecting emerging and potential scenarios as the ones represented by hidradenitis suppurativa, androgenetic alopecia, and hirsutism.

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Section: Insulin Insulin Resistance and Skinmentioning

confidence: 99%

Insulin Resistance and Skin Diseases

Napolitano

Megna

Monfrecola

2015

The Scientific World Journal

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“…In the last decade, it has been observed that the majority of women with PCOS presents some degree of insulin resistance, even non obese. Studies suggest the existence of Genetic predisposition, which ends up manifesting as a result of life style and obesity [16]. The resulting hyperinsulinemia insulin resistance causes an increase in both the production of androgens as in the biologically active portion.…”

Section: Insulin Resistancementioning

confidence: 99%

Polycystic Ovary Syndrome (PCOS) and Fertility

Barbosa¹,

Sá²,

Rocha³

et al. 2016

OJEMD

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The polycystic ovary syndrome (PCOS) is defined as a combination of hyperandrogenism (hirsutism and acne) and anovulation (oligomenorrhea, infertility, and dysfunctional uterine bleeding), with or without the presence of polycystic ovaries on ultrasound. It represents the main endocrine disorder in the reproductive age, affecting 6% -15% of women in menacme. It is the most common cause of infertility due to anovulation, and the main source of female infertility. When in the presence of a menstrual disorder, the diagnosis of PCOS is reached in 30% -40% of patients with primary or secondary amenorrhoea and in 80% of patients with oligomenorrhea. PCOS should be diagnosed and treated early in adolescence due to reproductive, metabolic and oncological complications which may be associated with it. Treatment options include drugs, diet and lifestyle improvement.

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“… 5 Levels of circulating androgens may be normal; however, local conversion may be increased due to a higher sensitivity of the receptors. 4 , 6 …”

Section: Introductionmentioning

confidence: 99%

Study of lipid profile in adult women with acne

Cunha¹,

Batista²,

Macedo³

et al. 2015

CCID

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ObjectiveThe aim of this study was to establish the lipid profile of female patients with acne in the Acne-in-Adult-Women Ambulatory Care Clinic in order to observe the prevalence of dyslipidemia in those patients.MethodsThis is a retrospective transversal study that evaluated the medical records of 416 patients who attended at the Acne-in-Adult-Women Ambulatory Care Clinic, at the Dermatology Department, Faculdade de Medicina do ABC, Santo André, São Paulo, Brazil, in the year 2012. Relevant data included age and clinical classification of acne. The lipid profile was analyzed according to the results of laboratory tests ordered during outpatient visits, which included total and fractionated cholesterol levels and triglycerides.ResultsThe epidemiological study sample was of 219 patients, with ages ranging from 21 to 61 years (mean of 32.23 years). The predominant clinical grade was papule-pustule acne (grade II) with 156 patients (71%). Regarding the lipid profile of the patients, there was a high increase in total cholesterol levels in 17.35% of the cases. High-density lipoprotein levels were low in 11.42% of the patients, with normal prevalence in 194 subjects. Low-density lipoprotein levels were normal in most patients (60.27%). Very-low-density lipoprotein values were normal in almost all patients (94.06%) and increased in only 13 patients (5.94%). Only 18 patients presented high levels of triglycerides (8.22%).ConclusionThe conclusion was that patients with grades II and III acne are more likely to have total cholesterol and low-density lipoprotein altered. A correct and early diagnosis can be an important measure for the prevention of the metabolic syndrome in these patients.

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Síndrome do ovário policístico: abordagem dermatológica

Cited by 44 publications

References 39 publications

Insulin Resistance and Skin Diseases

Insulin Resistance and Skin Diseases

Polycystic Ovary Syndrome (PCOS) and Fertility

Study of lipid profile in adult women with acne

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