Reações tegumentares adversas relacionadas aos agentes antineoplásicos: parte I

Abstract

Abstract:The local and systemic treatment of tumors can cause changes in the skin, mucous membranes, hair and nails. Accurate diagnosis and appropriate treatment of side effects require knowledge about the patterns of the most common adverse reactions to drugs the patient may be using. The dermatologist must be familiar with the manifestations of certain soft tissue neoplasms, as well as with the adverse mucocutaneous forms of cancer treatment. Keyword s: Chemotherapy, adjuvant; Drug therapy; Drug therapy, combination; Skin; Skin abnormalities; Skin pigmentation Resumo: O tratamento local e sistêmico das neoplasias pode causar alterações na pele, membranas mucosas, cabelos e unhas. O diagnóstico preciso e o tratamento adequado destes efeitos colaterais requerem conhecimento dos padrões das reações adversas mais comuns para as medicações que o paciente está utilizando. O dermatologista deve estar familiarizado com as manifestações tegumentares das neoplasias, bem como com os efeitos adversos mucocutâneos dos tratamentos antineoplásicos.

Inhibitory Effects of Resveratrol Analogs on Mushroom Tyrosinase Activity

“…Skin pigmentation disorders consist of an overproduction or uneven distribution of melanin, which results in skin spots that mainly affect mainly the face [2]. Such conditions may arise due to numerous factors, including skin aging, sun exposure [3,4], genetic factors [5], ethnicity [6,7], pregnancy [8], disease [9,10], use of certain medicines [11] and others.…”

Do you know this syndrome? Hand-foot syndrome

“…The two most commonly used criteria are provided by the World Health Organization and by the National Cancer Institute ( Chart 1 ). 7 …”

Persistent docetaxel-induced supravenous erythematous eruption

“… 2 , 3 The skin, the mucous membranes and skin appendages are tissues that have rapid cellular proliferation, therefore are very susceptible to adverse reactions resulting from anticancer systemic treatment. Docetaxel may cause a variety of side effects as alopecia, acral erythrodysesthesia, onycholysis, hyperpigmentation of the nail plate, urticaria, angioedema and persistent erythematous rash that follows the venous pathway 2 , 4 . The persistent erythematous eruption that follows the venous pathway, also known as serpiginous eruption, is characterized by erythematous macules or erythematous-purpuric papules at the site of infusion of the chemotherapeutic agent or along the venous pathway, which many times can progress with residual hyperpigmentation.…”