Childhood linear immunoglobulin A dermatosis is a rare autoimmune vesiculobullous
disease. It results in linear deposition of autoantibodies (immunoglobulin A)
against antigens in the basal membrane zone, leading to subepidermal cleavage.
Additional depositions of immunoglobulin G and complement-3 might occur. It is
still debated whether concomitant findings of immunoglobulins A and G should be
considered a subtype of this dermatosis or a new entity. Further studies are
needed to recognize this clinical variant.
Woolly hair nevus is a rare condition characterized by a structural anomaly of
the hair, restricted to certain areas of the scalp. The hair becomes coiled and
slightly hypopigmented. The term woolly hair refers to changes that affect all
the scalp and has a hereditary character. We present a case of woolly hair
nevus, that developed at the age of 2 years, associated with dental diastema and
verrucous epidermal nevus.
Taxanes are drugs used to treat many types of cancer, including breast and lung
cancer. The most common side effects of these drugs are neutropenia and mucositis.
Signs of skin toxicity are observed in about 65% of cases and include alopecia,
hypersensitivity reactions, persistent supravenous erythematous eruption, nail
changes, scleroderma reactions and others. We report two cases of skin reaction to
docetaxel and warn that it is not necessary to interrupt the treatment in these
cases.
Cowden's disease or multiple hamartoma syndrome is an autosomal dominant inherited
disease and the main dermatological features are facial trichilemmomas (hamartomas of
the follicular infundibula), oral fibroma and benign acral keratoses. The importance
of this disease lays in the increased susceptibility to malignization of some
lesions, especially breast, thyroid and genitourinary tract. Despite its varied
phenotypic expression, this disease is generally unknown. Consequently, many cases
are undiagnosed or diagnosis comes at a late stage, which reinforces the importance
of an early investigation of the disease so the patient may have periodic check-ups
to discover and treat malignancies.
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