Grupos sanguíneos e lúpus eritematoso crônico discoide

Abstract

Resumo: FUNDAMENTOS: Lesão discoide é a manifestação cutânea mais comum do lúpus eritematoso, e formas cutâneas crônicas apresentam características imunológicas próprias, direcionadas ao polo Th1. Diversas doenças possuem associação com grupos sanguíneos, o que não foi ainda estudado no lúpus discoide. OBJETIVO: Investigar a associação entre tipos sanguíneos (ABO e Rh) e lúpus eritematoso discoide. MÉTODOS: Estudo prospectivo tipo transversal envolvendo tipagem sanguínea ABO e Rh, inquérito de dados clínicos e dosagem de FAN e C4 de portadores de lúpus discoide sem critérios de doença sistêmica, atendidos em hospital universitário. RESULTADOS: Foram incluídos no estudo 69 pacientes, sendo 71,0% do sexo feminino (p < 0,01). A idade do surgimento da doença foi de 32,8 ± 13,1 anos. Formas disseminadas ocorreram em 47,8%; história de tabagismo foi verificada em 59,4%; FAN > 1:160, em 31,9%; e níveis baixos de C4, em 8,7%. Não houve diferença significativa entre as frequências dos grupos sanguíneos dos pacientes e da população local; entretanto, o grupo A foi associado às formas disseminadas da doença (OR 4,1 e p < 0,05). CONCLUSÕES: Grupos sanguíneos de pacientes com lúpus discoide apresentam frequência semelhante à da população; porém, formas clínicas disseminadas foram mais prevalentes entre portadores do grupo A. Palavras-chave: Epidemiologia; Lúpus eritematoso discoide; Sistema do grupo sanguíneo ABO; Sistema do grupo sanguíneo Rh-Hr Abstract: BACKGROUND: Discoid lesion is the commonest cutaneous finding in lupus erythematosus and chronic types have their own immunological features, with Th1 inflammation profile. Although many diseases have association with blood-group systems, this fact was not enlightened in discoid lupus erythematosus. OBJECTIVE: To investigate the association between blood groups (ABO and Rh) and discoid lupus erythematosus. METHODS: A prospective cross-sectional study assessing clinical information, blood group systems (ABO and Rh), FAN and C4 serum levels from discoid lupus patients without characteristics of systemic disease, was carried out at a clinic from a Brazilian university hospital. RESULTS: Sixty-nine patients were enrolled in the study, 71.0% were females (p<0.01), mean age of disease onset was 32.8±13.1 years, and disseminate form occurred in 47.8%, smoking was related in 59.4%, FAN>1:160 in 31.9%, and low levels of C4 in 8.7%. There was no significant difference between the frequency of blood groups from discoid lupus patients and local population, however, blood group A was associated to disseminate forms of the disease (OR 4.1 and p <0.05). CONCLUSIONS: Discoid lupus erythematosus patients with ABO and Rh blood groups exhibit similar frequencies as in the general population; nevertheless, disseminate clinical forms were more prevalent among group A patients.

The Relationship Between ABO Blood Groups and Psoriasis Vulgaris

“…Antigen A, more patients in this study were found in the erythrocytes of this antigen alone, but also the superficial tissues, such as leather carrying nuclear cells are also available [26]. A blood group B antigen in the form of people isoaglutinin cell membrane protein expression and antibody production may contribute to a hyperproliferative disease such as psoriasis can lead to the development of the phenotype.…”

“…There are publications that evaluated the relationship between blood groups and skin diseases such as vitiligo, pemphigus vulgaris, discoid lupus erythematosus, lichen planus and malignant skin tumors [21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32]. Antigenic expression of genes or genetic instability due to the separation from each other and contribute to the production of antibodies because of the different types of diseases associated with blood group [26]. There was no publication in the literature, assessing the relationship between ABO blood groups and psoriasis vulgaris.…”

“…ABO blood group genes are map at 9q in which the genetic alteration is common in many skin diseases [26]. Thus, ABO blood group antigen expression may be effected by the genetic change of dermatoses [22].…”

Male individuals with Robin Sequence: emerging significant association with ABO and RhD blood group phenotypes

“… 23 Tamega et al revealed predominance of the A phenotype in individuals with chronic discoid lupus erythematosus, thereby facilitating the prognosis in disseminated clinical presentations of the disease. 24 The study of Sharma et al demonstrated a higher prevalence of malocclusions in individuals with the B phenotype in the population of Jaipur, India. 25 It is important to point out that the present research demonstrated a possible association of RS with ABO and RhD blood group phenotypes.…”

DNA mobility shift assay as a tool for the detection of anti‐dsDNA antibodies in sera from discoid lupus erythematosus patients

“…Discoid lupus erythematosus occurs in genetically predisposed individuals and, although childhood DLE has been reported, the disease is usually detected in adults with a reported female : male ratio of 2.5:1 6,7 . Diagnosis is made by clinical examination and histopathology; additional laboratory tests occasionally performed include anti‐nuclear antibodies titers and presence of circulating antibodies against dsDNA.…”