Clinical correlations of recent developments in the pathogenesis of atopic dermatitis

Abstract

Atopic dermatitis is a chronic inflammatory skin disease with a steadily increasing prevalence affecting 10-20 % of infants and 1-3% of adults globally. It is often the first clinical manifestation of atopic disease preceding asthma and allergic rhinitis. Probably half of the children with atopic dermatitis develop some other form of atopic disease later in life. The pathogenesis involves a complex interplay of factors including genetic predisposition due to altered immune or skin barrier function, interactions with the environment such as food and allergen exposures, and infectious triggers of inflammation. In this review, we summarize the recent advances in understanding the contribution of different factors in the pathophysiology of atopic dermatitis and how insights provide new therapeutic potential for its treatment. Keywords: Asthma; Atopic Dermatitis, Eczema; Eosinophils; Genetics; Immunoglobulin E; Keratinocytes; Rhinitis, T-Lymphocytes Resumo: A dermatite atópica é uma doença cutânea inflamatória crônica cuja prevalência tem aumentado de forma constante, afetando 10-20% dos lactentes e 1-3% dos adultos em todo o mundo. Ela é freqüentemente a primeira manifestação clínica de doença atópica, precedendo a asma e a rinite alérgica. Provavelmente metade das crianças com dermatite atópica desenvolvem alguma

Association Between Atopic Dermatitis and Autism Spectrum Disorders: A Systematic Review

“…In turn, the enhanced inflammatory response may complicate AD with bacterial infections. Staphylococcal exotoxins activate LCs to produce inflammatory mediators, including IL-1b and tumor necrosis factor (TNF)-a [88]. In some cases AD is characterized by an increase in IgE levels, which is responsible for antigen presentation [18].…”

O uso da medicina alternativa ou complementar em crianças com dermatite atópica

“…1 Atopic dermatitis (AD) in childhood is a common disease and its incidence has been increasing. 2 The use of ACM has been increasing around the world, including for the treatment of AD and there are few clinical trials in the area. Homeopathy, phytotherapy, acupuncture, aromatherapy, chromotherapy, topical application of animal products, meditation practices, relaxation techniques, massages as therapy and nutritional diets constitute ACM resources used for treating atopic eczema.…”

“…(* In memorian) 2 Tutor from the post graduation course in Health Sciences from UnB, coordinator at the ambulatory of Dermatopediatrics from the University of Brasília (UnB) -Brasília (DF), Brazil.…”

Barreira cutânea na dermatite atópica

“…Any trauma to the barrier activates a cascade of cytokines secreted by keratinocytes, aggravating and perpetuating the inflammatory process. 43,44 Many mediating agents are involved in the genesis of the inflammated skin pruritus; histamine is essential, but not the only one: cytokines, prostaglandines, tachykinins, P substance, and others also play a role in the development of the symptom. 45 Another factor is the modulation of sensory nerves in the presentation of antigens and skin inflammation.…”