The Use of Fibrin Adhesive Derived From Snake Venom and the Evaluation of Skin Grafting Using Skin From the Patient’s Nasolabial Fold

Stolf, Hamílton Ometto

doi:10.1590/s0104-79301999000200011

Cited by 15 publications

(13 citation statements)

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“…Thus, preclinical trials applying the product in the peripheral nervous and musculoskeletal systems [46–56] and as a scaffold for stem cells have been studied extensively [57–60]. Trials in plastic surgery skin repair [61], periodontal surgery [62–64] and in chronic venous ulcers have also been performed [41, 65]. In addition to treating chronic venous ulcers, further clinical trials, especially ones linked to the nervous system and to skeletal muscle, will allow for a more precise use.…”

Section: Discussionmentioning

confidence: 99%

Heterologous fibrin sealant derived from snake venom: from bench to bedside – an overview

Ferreira

Barros

Abbade

et al. 2017

J Venom Anim Toxins Incl Trop Dis

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Hemostatic and adhesive agents date back to World War II, when homologous fibrin sealant came onto scene. Considering that infectious diseases can be transmitted via human blood, a new heterologous fibrin sealant was standardized in the 1990s. Its components were a serine protease (a thrombin-like enzyme) extracted from the venom of Crotalus durissus terrificus snakes and a fibrinogen-rich cryoprecipitate extracted from the blood of Bubalus bubalis buffaloes. This new bioproduct has been used as a coagulant, sealant, adhesive and recently as a candidate scaffold for mesenchymal stem cells and bone and cartilage repair. This review discusses the composition of a new heterologous fibrin sealant, and cites published articles related to its preclinical applications aiming at repairing nervous system traumas and regenerating bone marrow. Finally, we present an innovative safety trial I/II that found the product to be a safe and clinically promising candidate for treating chronic venous ulcers. A multicenter clinical trial, phase II/III, with a larger number of participants will be performed to prove the efficacy of an innovative biopharmaceutical product derived from animal venom.Electronic supplementary materialThe online version of this article (doi:10.1186/s40409-017-0109-8) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Heterologous fibrin sealant derived from snake venom: from bench to bedside – an overview

Ferreira

Barros

Abbade

et al. 2017

J Venom Anim Toxins Incl Trop Dis

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“…The advantages of this adhesive are that it does not transmit infectious agents that might be present in human blood and the availability of an abundant source of the material because of the size of the animals donating the fibrinogen and the possibility of raising snakes to donate the venom 6 . Stolf 7 evaluated this new adhesive in human skin surgery. The cosmetic evaluation of the scar formation was excellent for the glued area, and the patients did not show any local or systemic toxic effects.…”

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confidence: 99%

Fibrin Adhesive Derived From Snake Venom in Periodontal Surgery

Barbosa¹,

Gregh²,

Passanezi³

2007

Journal of Periodontology

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“…It is an adhesive consisting of a thrombinlike enzyme isolated from the Crotalus durissus terrificus snake venom (rattlesnake), which replaces the thrombin. Human fibrinogen is replaced by another enzyme obtained by means of buffalo blood fractioning 12 . Stolf 12 (1999) evaluated this new adhesive in human skin surgery.…”

Section: Introductionmentioning

confidence: 99%

“…Human fibrinogen is replaced by another enzyme obtained by means of buffalo blood fractioning 12 . Stolf 12 (1999) evaluated this new adhesive in human skin surgery. Cosmetic evaluation of the scar formation was excellent for the glued area and the patients did not show any local or systemic toxic effects.…”

Section: Introductionmentioning

confidence: 99%

Fibrin adhesive derived from snake venom in periodontal surgery: histologicalanalysis

Barbosa¹,

Stipp

Passanezi

et al. 2008

J. Appl. Oral Sci.

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Background:A new fibrin adhesive made of buffalo plasma-derived fibrinogen and a thrombin-like snake venom enzyme, has been successfully used to immobilize free gingival grafts. This case series histologically compared sutured grafts (control group) with others immobilized by using the fibrin adhesive (experimental group).Case Description:The grafts were placed in the contralateral mandibular bicuspids of 15 patients, so that each subject received one treatment of each type. Five biopsies of each group were collected at 7, 14 and 45 days of healing, which were histologically and morphometrically analyzed as regards the relative volume density of the different connective tissue components.Results:The sites in the control group presented a higher inflammatory cell density at 7 days and a tendency towards a lower collagen density. In the experimental group, the grafts had an appearance of more advanced healing. Tissue maturity characteristics progressed until 14 and 45 days, but no difference between groups could be noted at these times.Conclusions:Within the limits of the present study, it may be suggested that the alternative fibrin adhesive tested could represent an alternative to sutures in gingival grafts procedures.

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The Use of Fibrin Adhesive Derived From Snake Venom and the Evaluation of Skin Grafting Using Skin From the Patient’s Nasolabial Fold

Cited by 15 publications

References 0 publications

Heterologous fibrin sealant derived from snake venom: from bench to bedside – an overview

Heterologous fibrin sealant derived from snake venom: from bench to bedside – an overview

Fibrin Adhesive Derived From Snake Venom in Periodontal Surgery

Fibrin adhesive derived from snake venom in periodontal surgery: histologicalanalysis

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