Estudo experimental anatômico-funcional da cocleotoxicidade da gentamicina com doses habituais para recém-nascidos

“…The authors conclude that the use of a protocol that verifies and validates the fitting of hearing aids in children is necessary. Baggio et al (2009) point that gentamicin is an antibiotic that acts in Gram-negative bacilli infections, having otoxicity as one of the most important side effects. seu efeito colateral mais importante é a ototoxicidade.…”

Section: Mota and Melo Filhamentioning

confidence: 99%

Editorial

Andrade

2009

Pró-Fono R. Atual. Cient.

View full text Add to dashboard Cite

Prezados leitores, O segundo Editorial de 2009 procura compartilhar uma discussão sobre os fatores que influenciam mais ou menos a decisão de um fonoaudiólogo em cursar e concluir um curso de pós graduação estrito senso (mestrado e doutorado) na área. Todos sabemos que a formação de doutores -em campo específico -implica no futuro da Fonoaudiologia, quer quanto à autonomia na geração de conhecimento (pesquisas), quer quanto na prática clínica baseada em evidências (fundamentos que venham de encontro à demanda dos serviços).Dados americanos do Conselho de Programas Acadêmicos em Ciências e Distúrbios da Comunicação Humana (CAPCSD) indicam que num estudo retrospectivo de 20 anos, existe -na América -um perfil de estabilidade do número de fonoaudiólogos que buscam a titulação de doutores. Este número não acompanha o número crescente de profissionais que terminam a graduação e nem refletem as demandas populacionais pelos serviços de Fonoaudiologia.Segundo o CAPCSD, os fatores considerados positivos -ou seja, as razões para quem busca um programa de mestrado e doutorado -são:. gosto e interesse acadêmico e pela pesquisa; . desejo de ter um foco de expertise, respeito e credibilidade confiados pela sociedade ao profissional que se titula; . desejo de crescimento profissional que é refletido pela ascensão aos graus da carreira.Para este conselho, os fatores considerados negativos -ou seja, as razões para quem não busca um programa de mestrado e doutorado -são:. considerações familiares; . fatores financeiros (ganha-se menos na vida acadêmica do que na prática clínica); . falta de interesse e disponibilidade pessoal para estudar; Dear Readers, The second Editorial of 2009 shares a discussion about the factors that, more or less, have an influence on the speech-language pathologist's and audiologist's decision to attend and conclude a post graduation course (master and doctorate) in this area of knowledge. We all know that the formation of doctors -in a specific field of knowledge -implies in the future of the Speech, Language and Hearing Sciences, not only in terms of autonomy for generating knowledge (researches), but also in terms of evidence based clinical practice (basis that attend services demands).American data of the Council of Academic Programs in Sciences and Human Communication Disorders (CAPCSD) indicates, in a retrospective study of the last 20 years, stability in the number of speech-language pathologists and audiologists -in America -who look for a doctorate degree. This number does neither follow the growing number of professionals who conclude graduation or attend population demands for Speech-Language and Hearing services.According to the CAPCSD, factors considered as being positive -i.e. the reasons to look for a master or doctorate program -are:. academic like and interest for research; . desire to have a focus of expertise, respect and credibility given by the society to the professional who receives the title; . desire for professional growth, reflected by the ascension in the career steps.For this...

show abstract

Interaction of gentamicin with phosphatidylserine/phosphatidylcholine mixtures in adsorption monolayers and thin liquid films: morphology and thermodynamic properties

Georgiev

Lalchev

2010

Eur Biophys J

View full text Add to dashboard Cite

Gentamicin possesses strong adverse actions like oto and nephrotoxicity. The latter is a result of strong gentamicin-acid phospholipid interactions, resulting in cell fusion, fission, etc., ions as calcium interact with gentamicin and effectively deter its toxicity. In this work, the interactions of gentamicin and Ca(2+) with phosphatidylserine/phosphatidylcholine (PS/PC) mixtures of different ratio are experimentally characterized. Special attention is paid to bridge thermodynamic and morphological properties of adsorption monolayers and thin liquid films (TLFs) composed of these lipid mixtures. Our results show that gentamicin decreases the stability of common black TLFs formed of pure PS coupled with suppression of lipid surface adsorption to the monolayers at the air-water interface; also, gentamicin reveals effects of lowering of lipid spreading on the interface and significant loss of material during monolayer cycling, increase of condensed phase, and organization of dense net-like domain monolayer texture. Gentamicin addition results in opposite effects for films formed of DPPC/PS (95:5) mixture. It increases the stability of Newton black TLFs formed by DPPC/PS correlated with faster and stronger surface adsorption and better surface spreading; also, gentamicin lowers the amount of condensed phase and organization of domains of smaller size. We also showed that Ca(2+) itself decreases the stability of common black TLFs formed of PS accompanied with weaker surface adsorption, formation of higher amounts of condensed phase and organization of domains. In our experiments, Ca(2+) softens, even deters, the effects of gentamicin on both PS and DPPC/PS films.

show abstract

Estudo experimental anatômico-funcional da cocleotoxicidade da gentamicina com doses habituais para recém-nascidos

Abstract: lesions or alterations in the functioning of the ECC of albino guinea-pigs after the use of 4 mg/Kg/day and 2,5mg/Kg/day every 12 hours for a period 10 and 14 days were not observed.

Cited by 3 publications

References 10 publications

The effects of hyperbaric oxygen therapy upon ototoxic injuries produced by amikacin in guinea pigs

The effects of hyperbaric oxygen therapy upon ototoxic injuries produced by amikacin in guinea pigs

Editorial

Interaction of gentamicin with phosphatidylserine/phosphatidylcholine mixtures in adsorption monolayers and thin liquid films: morphology and thermodynamic properties

Contact Info

Product

Resources

About