O papel das selenoproteínas no câncer

Almondes, Kaluce Gonçalves de Sousa; Leal, Greisse Viero da Silva; Cozzolino, Sílvia Maria Franciscato; Philippi, Sônia Tucunduva; Rondó, Patrícia Helen de Carvalho

doi:10.1590/s0104-42302010000400025

Cited by 30 publications

(11 citation statements)

References 61 publications

(70 reference statements)

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“…In addition, it can act in the formation of hormones, in DNA synthesis, fertility, reproduction, increasing muscle functions, and delaying the aging process (Suttle, 2010;Cabaraux et al, 2006). Furthermore, there are reports of cancer prevention through the action of selenoenzymes, which reduce damages caused to the DNA and decreases reactive oxygen species, increasing the production of tumor suppressor proteins (Almondes et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Agronomic biofortification of carrot with selenium

et al. 2018

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The selenium (Se) is essential for human metabolism, but a large part of the world's population has deficiency in this element. This can be reversed by the consumption of biofortified foods, given that plants can efficiently act in controlling excessive and/or accidental consumption of an element that can occur in humans through the use of dietary supplements. The objective of this study was to evaluate the effect of different application forms and sources of Se in the growth, production, nutrition, physical-chemical characteristics, content and accumulation of Se in carrots. The experiment was conducted under greenhouse conditions, using pots containing 4 dm 3 of Red-yellow Latosol. A completely randomized design was used in a 2x2x2 factorial scheme (with and without Se application, two sources of Se: selenate and selenite, two forms of application of Se: soil and foliar applications), with five replicates. Foliar application of selenate increased the yield and titratable acidity, reducing root ripening index. Foliar application of selenite increased the content of Se in the shoots and the content of carotenoids in the roots. Both sources of Se (selenate and selenite) and application forms (soil or foliar application) increased their content in the roots. However, the foliar application of selenate was the most effective source and form of application. Therefore, it is possible to increase the contents of Se in the edible part of carrots, favoring the consumption of this element by the population. Index terms:Daucus carota Lam; selenate; selenite; maturation index; carotenoids. RESUMOO selênio (Se) é essencial para o metabolismo humano, porém, grande parte da população mundial apresenta deficiência nesse elemento. Isto pode ser revertido pelo consumo de alimentos biofortificados, uma vez que as plantas podem atuar de forma eficiente no controle do consumo excessivo e / ou acidental de um elemento que pode ocorrer nos seres humanos através do uso de suplementos dietéticos. Objetivou-se com o presente estudo avaliar o efeito de formas de aplicação e fontes de Se no crescimento, produção, nutrição, características físico-químicas, teor e acúmulo de Se na cenoura. O experimento foi desenvolvido em casa de vegetação, utilizando vasos com quatro dm 3 contendo Latossolo Vermelho Amarelo. Adotou-se o delineamento inteiramente casualizado, em fatorial 2 x 2 x 2 (com e sem aplicação do Se; duas fontes do Se: selenato e selenito; duas formas de aplicação do Se: via solo e foliar), com cinco repetições. O selenato aplicado via foliar aumenta a produção e a acidez titulável e reduz o índice de maturação das raízes. O selenito via foliar aumenta o teor de Se na parte aérea e o teor de carotenoides nas raízes de cenoura. As duas fontes de Se (selenato e selenito) e formas de aplicação (via solo ou foliar) promovem aumento do seu teor nas raízes de cenoura, porém o selenato via foliar é a fonte e forma mais efetiva. Dessa forma, é possível aumentar os teores de Se na parte comestível da cenoura e, assim, favorecer a in...

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Section: Introductionmentioning

confidence: 99%

Agronomic biofortification of carrot with selenium

et al. 2018

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“…A selenometilselenocisteína é o principal composto de selênio encontrado em vegetais como alho, cebola, brócolis e alho poró. 13 A presença ou combinação de alguns fatores como concentração de proteínas, vitaminas E e A na dieta, presença de inibidores como metais pesados (cádmio, mercúrio e enxofre), a própria concentração de selênio, bem como a forma química do mineral presente na dieta podem influenciar a sua biodisponibilidade. Outros fatores, como as interações ocasionadas pela ingestão de compostos presentes na dieta, tais como o conteúdo de fitatos, pectina e fibras totais podem reduzir a biodisponibilidade do selênio.…”

Section: Aspectos Metabólicos E Fisiológicos Do Selêniounclassified

Participação do selênio no diabetes mellitus tipo 2

Beserra¹,

Oliveira²,

Feitosa³

et al. 2015

Nutrire

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Objective: This review aims to bring updated information on the relationship between oxidative stress and the role of selenium as antioxidant nutrient in mechanisms involved in the pathogenesis of type 2 diabetes mellitus. Data source: The bibliographic survey was conducted in PubMed, SciELO and Lilacs, considering the 2002-2014 period, and included the following types of studies: randomized or quasi-randomized controlled trials, cohort, case-control study, case series and case report. Forty-nine pertinent scientific studies were selected. Data synthesis: Several studies have demonstrated the contribution of acute and/or chronic hyperglycemia to the manifestation of oxidative stress in type 2 diabetic patients. Accordingly, selenium has an important participation in controlling this disease due to its antioxidant role in the elimination of free radicals, present in excess, and because it blocks the activation of nuclear transcription factor kappa B, a regulator sensitive to oxidants that stimulates the production of inflammatory mediators (cytokines) and adhesion molecules. Conclusions: There is convincing experimental evidence demonstrating the involvement of selenium in glycemic control. However, current information is still scarce and inconsistent, and it is necessary to conduct further studies on the subject to determine the selenium intake safety range as well as clarify the influence of this mineral on the manifestation of type 2 diabetes mellitus and its associated disorders.

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“…The protective effect of this mineral is especially associated with its presence in glutathione peroxidase and thioredoxin reductase, enzymes that protect the DNA and other cellular components against oxidative damage caused by ROS. Several studies have demonstrated reduced expression of these enzymes in various types of cancer, especially when associated with a low intake of selenium, which may exacerbate the damage (Almondes et al, 2010). A total of 1312 patients (mean age, 63 years; range, 18-80 years) with a history of basal cell or squamous cell carcinomas of the skin were randomized from 1983 through 1991.…”

Section: Seleniummentioning

confidence: 99%

Antioxidants in Cancer Treatment

Nepomuceno¹

2011

Current Cancer Treatment - Novel Beyond Conventional Approaches

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Current Cancer Treatment-Novel Beyond Conventional Approaches 624 concern that antioxidants might reduce oxidizing free radicals created by radiotherapy and some forms of chemotherapy, and thereby decrease the effectiveness of the therapy. The authors that support the idea that administration of oral antioxidants is contraindicated during cancer therapeutics, suggest that a drug's ability to destroy micrometastases may be impaired by the addition of antioxidants and, this may result in an improved short-term tolerance to treatment followed by an increased long-term chance for recurrence. On the other hand, there are several articles showing no evidence of significant decreases in the efficacy of chemotherapy with antioxidant supplementation and that supplementation of antioxidant vitamins during cancer treatment is effective, increasing quality and life expectancy. Considering that the use of antioxidants during treatment is a very contentious issue, the purpose of this chapter is to review studies in humans to evaluate the use of these antioxidants as a therapeutic intervention in cancer patients, and their interactions with radiation therapy and chemotherapy. 2. Classes of agents used in cancer treatment that produce a reactive oxygen compound or free radical The ultimate clinical effectiveness of any anti-cancer drug requires that it kill malignant tumor cells in vivo at doses that allow enough cells in the patient's critical tissues (e.g., bone marrow, gastrointestinal tract) to survive so that recovery can occur. This is difficult to accomplish because, in general, anticancer drugs are most useful against malignant tumor with a high proportion of dividing cells, and some normal tissues such as the bone marrow and G1 tract also have a high cell-proliferation rate. Anticancer drugs used by themselves are primarily effective against high-growth-fraction tumors such as the leukemias and lymphomas. The most common malignant tumors, however, are "solid" tumors, including those of the colon, rectum, lung and breast. These tumors usually have a low proportion of dividing cells and therefore are less susceptible to treatment by drugs alone (Pratt, 1994). There are some standard methods of cancer treaments: surgery, chemotherapy, radiation therapy, immunotherapy and biologic therapy. Undoubtedly, chemotherapy and radiotherapy are the treatments to fight cancer with more side effects. Chemotherapy agents can be divided into several categories: alkylating agents (e.g., cyclophosphamide, ifosfamide), antibiotics which affect nucleic acids (e.g., doxorubicin, bleomycin), platinum compounds (e.g., cisplatin), mitotic inhibitors (e.g., vincristine), antimetabolites (e.g., 5-fluorouracil), camptothecin derivatives (e.g., topotecan), biological response modifiers (e.g., interferon), and hormone therapies (e.g., tamoxifen). The agents most noted for creating cellular damage by initiating free radical oxidants are the alkylating agents, the tumor antibiotics, and the platinum compounds (Lamson & Brignall, 1999). 2.1 Alkylating ...

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O papel das selenoproteínas no câncer

Cited by 30 publications

References 61 publications

Agronomic biofortification of carrot with selenium

Agronomic biofortification of carrot with selenium

Participação do selênio no diabetes mellitus tipo 2

Antioxidants in Cancer Treatment

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