Participação do selênio no diabetes mellitus tipo 2

Beserra, Bruna Teles Soares; Oliveira, Ana Raquel Soares de; Feitosa, Mayara Monte; Cruz, Kyria Jayanne Clímaco; Torres–Leal, Francisco Leonardo; Marreiro, Dilina do Nascimento

doi:10.4322/2316-7874.03213

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…Furthermore, higher dietary Se intake may increase the release of glucagon and consequently increase hyperglycemia (53), and increase the expression of glutathione peroxidase 1. The high activity of this enzyme may interfere with insulin signaling, favoring resistance to the action of insulin, and hyperinsulinemia (54).…”

Section: Discussionmentioning

confidence: 99%

Dietary Selenium Intake and Type-2 Diabetes: A Cross-Sectional Population-Based Study on CUME Project

et al. 2021

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Background and Aim: Previous studies have suggested that the specific association between selenium (Se) and diabetes remains unclear. This study aimed to investigate the association between dietary Se and type-2 diabetes (T2D) in the Brazilian cohort [Cohort of Universities of Minas Gerais (CUME)].Methods and Results: This cross-sectional study was conducted with a large sample comprising 4,106 participants of the CUME project, a concurrent open cohort restricted to a highly educated population group, composed of graduates of federal institutions of higher education located in the State of Minas Gerais, Brazil. Data on socioeconomic and dietary characteristics, as well as anthropometric measures, were collected from each subject for analysis. The sample was classified into energy-adjusted tertiles of dietary Se intake (μg/day). Differences in the continuous data were evaluated by the Kruskal–Wallis H-test (abnormal data), and the χ2-test assessed differences in qualitative data. As there was no relationship between T2D and Se intake in the bivariate analysis, multivariate analysis was not performed. The prevalence of T2D in the studied population was 2.8%. The mean age was 36 years. Regarding gender, 1,209 are males and 2,807 are females. Among females, the mean Se intake was 165.12 μg/day and the mean intake was 157.4 μg/day. Among males, it was 168.4 μg/day. Significant differences were observed across all Se intake tertiles in terms of age, gender, activity level, alcohol intake, energy intake, sugar, carbohydrates, lipids, fiber, and energy-adjusted meat intake. However, no significant differences were observed across all Se intake tertiles in terms of BMI, smoking status, and T2D. The results indicated that there was no significant association between dietary Se intake and the prevalence of T2D.Conclusion: Dietary Se intake was not associated with the prevalence of T2D, despite the high intake of this micronutrient in the sample. These results contradict studies that identified the association between Se intake and T2D, with values of Se intake much lower than those observed in this study. Thus, this relationship seems to remain controversial.

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Section: Discussionmentioning

confidence: 99%

Dietary Selenium Intake and Type-2 Diabetes: A Cross-Sectional Population-Based Study on CUME Project

et al. 2021

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Selenium Concentrations and Their Relation to Insulin Resistance in Obese Women

Soares

Cardoso

Dias

et al. 2023

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Several studies have shown the importance of selenium in preventing important metabolic disorders associated with obesity, such as chronic inflammation, oxidative stress and insulin resistance. However, the results of these studies are still controversial. Thus, this study aimed to evaluate selenium concentrations and their relation to insulin resistance in obese women. A cross-sectional study involving 213 women divided into a case group (obese women, n = 84) and a control group (eutrophic women, n = 129). Energy, macronutrient and selenium intake were obtained from the three-day food record. Evaluation of selenium in plasma, erythrocyte and urine was performed by inductively coupled plasma optical emission spectrometry. Serum glucose concentrations were determined according to the colorimetric enzymatic method. Fasting insulin and glycated hemoglobin were analyzed according to the chemiluminescence method. The mean values of dietary selenium intake (µg/kg/day) by obese women were lower than the control group (p < 0.001). Plasma and erythrocyte concentrations had reduced values in the obese women (p < 0.001), while selenium concentrations found in urine were higher (p < 0.001). There was no statistical difference between the groups regarding glycemic control parameters (p > 0.05). There was a positive correlation between dietary selenium intake (µg/day), fasting insulin, glycated hemoglobin and HOMA-β, as well as between dietary intake (µg/kg/day), fasting insulin and HOMA-β (p < 0.05). The evaluated women with obesity present alterations in the nutritional status regarding selenium. In addition, it evidences a positive relationship between dietary selenium and markers of glycemic control, which may reflect the possible negative action of selenium on insulin action signaling.

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Participação do selênio no diabetes mellitus tipo 2

Cited by 2 publications

References 38 publications

Dietary Selenium Intake and Type-2 Diabetes: A Cross-Sectional Population-Based Study on CUME Project

Dietary Selenium Intake and Type-2 Diabetes: A Cross-Sectional Population-Based Study on CUME Project

Selenium Concentrations and Their Relation to Insulin Resistance in Obese Women

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