What factors affect the quality of life of patients with keloids?

Furtado, Fabianne; Hochman, Bernardo; Ferrara, Soraia Francisco; Dini, Gal Moreira; Nunes, José Mário Camelo; Juliano, Yára; Ferreira, Lydia Masako

doi:10.1590/s0104-42302009000600014

Cited by 43 publications

(44 citation statements)

References 17 publications

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“…Keloids are intradermal proliferations of the cutaneous connective tissue, secondary to an abnormal skin repair process with accumulation of collagen . In sub‐Saharan Africa, the frequency of ritual practices of scarification, tattooing, and piercing coupled with the predisposition of the black skin to develop this anomaly make keloids a nightmare for sub‐Saharan Africans, particularly when these lesions are located on uncovered areas . Keloids usually cause few complications, but depending on their size, localization, and associated symptoms, they can lead to functional, esthetic, and/or psychological harm .…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and clinical features of keloids in Black Africans: a nested case–control study from Yaoundé, Cameroon

et al. 2019

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Background Keloids are a common presenting complaint in Black Africans but remain poorly documented in these populations. The aim of our study was to describe the epidemiological and clinical profiles of patients with keloids seen at dermatology outpatient consultations in Yaoundé (Cameroon) and to determine driving factors of keloid occurrence. Methods This was a 1 : 2 case–control study conducted from February to May 2016 at the dermatology unit of five health facilities in Yaoundé, Cameroon. Cases were patients with black skin and diagnosed with keloids while controls had no keloid scar, paired to cases according to age and sex. The diagnosis of keloid was based on clinical history and findings. Results Of 2,940 patients seen during the study period, 102 (54.9% females) had keloids, hence a prevalence of 3.5% (95% confidence interval [CI]: 2.8–4.2). The most affected age group was ≥25 years (69.6%). Lesions at the origin of keloids were mostly traumatic (66.7%). In 68 patients (66.7%), keloid scars were associated with pruritus. The presternal region was the predominant localization (26.5%). Existence of a family history of keloids was significantly associated with presence of keloids (adjusted odds ratio: 4.2, 95% CI: 2.4–7.2; P < 0.001). Conclusions Keloids commonly affect black skin as recorded during dermatology consultations in Yaoundé, Cameroon. More often, they are secondary to skin trauma and seem to occur among those with a family history of keloids. Therefore, these people should be closely monitored accordingly.

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Section: Introductionmentioning

confidence: 99%

Epidemiology and clinical features of keloids in Black Africans: a nested case–control study from Yaoundé, Cameroon

et al. 2019

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“…[1][2][3][4][5] Keloids share several features with hypertrophic scars, including excessive extracellular matrix deposition caused by unknown mechanisms 6 ; significant morbidity caused by itching, pain, and decreased range of motion 7 ; profoundly impacted psychosocial well-being; and impaired overall quality of life for affected patients. [7][8][9][10] Importantly, there are no real cures for either type of scar, despite the availability of multiple treatment options. [11][12][13] The fact that there are no universally accepted treatments for either keloids or hypertrophic scars underscores the heterogeneity of these debilitating lesions and indicates that the key mechanisms involved in abnormal scarring remain to be elucidated.…”

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confidence: 99%

Deep and Superficial Keloid Fibroblasts Contribute Differentially to Tissue Phenotype in a Novel In Vivo Model of Keloid Scar

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Glaser

et al. 2012

Plastic &Amp; Reconstructive Surgery

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“…Some experts see it as just an aesthetic problem [57], but the quality of life of individuals with keloids is as highly affected as with psoriasis and vitiligo [58]. Itching, pain, functional disability and a stretching sensation are commonly reported by keloid carriers [45,46]. The lack of options for clinical treatment, the possibility of postoperative recurrence, and the chances for the emergence of new lesions give the patients the idea that they are suffering from a chronic disease.…”

Section: Discussionmentioning

confidence: 99%

“…The Brazilian version is called "Questionário QualiFibro/Cirurgia Plástica-UNIFESP" [46]. It is composed of questions that are divided into two scales after the scores are processed: one scale shows physical damage and the other scale analyzes the psychological damage.…”

Section: Quality Of Lifementioning

confidence: 99%