Leishmaniose tegumentar americana

Abstract

Homem, 68 anos, trabalhador rural, natural e procedente de Sabará/MG, foi atendido previamente pelo Serviço de Clínica Médica da Santa Casa de Sabará. Apresentava uma extensa úlcera na perna esquerda, indolor, de bordas bem definidas e moderada secreção purulenta, com início havia sete meses. Tabagista (20 cigarros/dia por 40 anos) e hipertenso (em uso de hidroclorotiazida 25 mg/dia). Negava diabetes e uso de outras medicações. Sem outras queixas. Ausculta cardíaca e pulmonar sem alterações. Abdome normal sem tumorações e visceromegalias. Pesquisa bacteriológica e cultura da secreção produzida identificaram presença de Staphylococcus aureus. Recebeu tratamento com antibiótico oral (cefalexina 500 mg) e agentes tópicos, sem resultados. Consultou outros médicos em duas outras situações. Em ambas recebeu tratamento semelhante sem alteração do quadro. Um cirurgião vascular descartou a possibilidade de doença periférica arterial FATORES ASSOCIADOS À INTERRUPÇÃO DE TRATAMENTO ANTI-RETROVIRAL TRATAMENTO DE CRIANÇAS DESNUTRIDAS HOSPITALIZADAS SARNI ROS ET AL.

Diethyldithiocarbamate loaded in beeswax-copaiba oil nanoparticles obtained by solventless double emulsion technique promote promastigote death in vitro

“…This disease presents manifestations ranging from the formation of the single ulcer to disseminated forms and can affect the mucous [1,2]. It consists of a Public Health problem, due to its high incidence, wide distribution and great complexity, with the possibility of the appearance of destructive, disfiguring and even incapacitating lesions for infected individuals [3,4]. Despite advances in parasite studies, as well as knowledge of the disease, therapies have now been based on the use of pentavalent antimonials such as sodium stibogluconate (Pentostam®) and antimoniate N-methyl-glucamine (Glucantime®), besides the use of amphotericin B or pentamidines, however they present difficulties of administration, high cost and important side effects [5][6][7].…”

Leishmaniose tegumentar americana: estudo clínico, epidemiológico e laboratorial realizado no Hospital Universitário de Campo Grande, Mato Grosso do Sul, Brasil

“…This variation has been associated with the patient's immunological status and with the species of Leishmania. 3,[11][12][13] This aspect of the infection makes clinical diagnosis difficult, and there needs to be a strong proof of suspicion of the disease.…”

Ecological aspects and molecular detection of Leishmania DNA (Kinetoplastida: Trypanosomatidae) in phlebotomine sand flies (Diptera: Psychodidae) from a rural settlement in the Eastern Amazon, Brazil

“…(V.) braziliensis in Acre (Ávila et al, 2018), Rondônia (Grimaldi et al, 1991) and Pará (Souza et al 2010), Le. (L.) amazonensis in Amazonas and Rondônia (Resadore et al, 2019), besides being also considered one of the potential vectors of Leishmania (V.) naiffi in the Amazon region (Castellón et al, 1994;Gontijo and Carvalho, 2003;Gonçalves et al, 2016). This species has already been found as the most abundant in studies carried out in the Eastern Amazon (18.2%) (Pereira Júnior et al, 2019), in our study, it was the fifth most collected species (6.0%), and was found infected with DNA from Leishmania spp.…”