Bupivacaína racêmica, levobupivacaína e ropivacaína em anestesia loco-regional para oftalmologia: um estudo comparativo

Magalhães, Edno; Govêia, Cátia Sousa; Oliveira, Keyla B.

doi:10.1590/s0104-42302004000200038

Cited by 13 publications

(13 citation statements)

References 12 publications

(12 reference statements)

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“…The short latency for maximal motor blockade in both groups in the present study is in accord to the report of previous works 15,49 . Peribulbar anesthesia can cause a temporary increase in the intraocular pressure due to the compressive effect of anesthetic solution on the eye and increase in intraorbital pressure.…”

Section: Discussionsupporting

confidence: 94%

“…A small increase, between 13 mmHg and 15.6 mmHg was observed without clinical significance, since the levels remained within normal limits. This increase, followed by a reduction of the intraocular pressure in bupivacaine group, is in agreement with other reports in the literature 15,50 . In ropivacaine group, a significant reduction or even a tendency towards stabilization of intraocular pressure was observed with values around 13 mmHg in all measurements.…”

Section: Discussionsupporting

confidence: 93%

“…Comparison of different concentrations of ropivacaine in 68 patients showed that the concentration of 0.75% is preferable to 0.5% and 1.0%, which produce, respectively, lower akinesia and prolonged anesthetic recovery 36 . Comparing peribulbar ropivacaine, racemic bupivacaine, and levobupivacaine, all in concentrations of 0.75%, in 96 patients, significant differences regarding the quality of the motor blockade were not observed 15 . Equimolar concentrations of ropivacaine and bupivacaine in peribulbar anesthesia seem to have the same anesthetic potency.…”

Section: Discussionmentioning

confidence: 88%

“…In peribulbar anesthesia, the profile of ropivacaine regarding latency and intensity of the motor blockade is similar to that of bupivacaine 15 . However, its vasoconstrictive effect on the ocular circulation remains unknown.…”

Section: Introductionmentioning

confidence: 89%

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Anestesia peribulbar com ropivacaína: estudo da ação vasoconstritora

Govêia¹,

Magalhãe²

2010

Rev. Bras. Anestesiol.

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Summary: Govêia CS, Magalhães E -Ropivacaine in Peribulbar Anesthesia -Vasoconstrictive Properties.Background and objectives: Peribulbar anesthesia can reduce ocular blood flow (OBF) by increasing intraocular pressure (IOP) or due to the action of drugs. Ropivacaine has low toxicity and intrinsic vasoconstrictive properties, yet to be proven on the ocular vasculature. Measurements of ocular pulse amplitude (OPA) allow the indirect evaluation of the OBF. The objective of the present study was to evaluate through the OBF the vasoconstrictive properties of ropivacaine in peribulbar anesthesia.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 89%

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Anestesia peribulbar com ropivacaína: estudo da ação vasoconstritora

Govêia¹,

Magalhãe²

2010

Rev. Bras. Anestesiol.

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“…As the period of action of a local anesthetic is characterized by the contact time of this anesthetic with the nerve (GREENE, 2002) and the volume and concentration used (MAMA;STEFFEY, 2003;MAGALHÃES;GOVÊIA;OLIVEIRA, 2004), we infer that branches from the facial nerve that address the secretory function of the lacrimal gland would be less subject to the action of anesthetics compared to those responsible for the sensory part of the cornea. In any event, the innervation of the lacrimal gland is not completely understood, and it is known that other nerve branches are involved in its function (SLATTER, 2005;SAMUELSON, 2007), as well as the third eyelid gland which also helps with tear production, although to a lesser extent (SLATTER, 2005;GIULIANO;MOORE, 2007).…”

Section: Discussionmentioning

confidence: 99%

Ocular effects of retrobulbar block with different local anesthetics in healthy dogs

et al. 2014

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The objective of this study was to evaluate the ocular effects, the feasibility and the quality of retrobulbar block using the inferior temporal technique with different local anesthetics applied with the Tuohy epidural needle in dogs. Eight dogs were included in the experiment and each one was studied four times, with interval of 15 days between the treatments: Lido -2% lidocaine, Ropi -0.75% ropivacaine, Bupi -0.5% racemic bupivacaine and Levo -0.75% levobupivacaine. Except for the ropivacaine, all of the local anesthetics contained epinephrine at 1:200.000. The blocks were performed in the right eyes immediately after anesthetic induction, and the left eyes were not blocked and were used as controls. The intraocular pressure, tear production and corneal sensitivity were evaluated before any procedure (T0), 30 min after premedication (TMPA), 30 min after anesthetic induction (T30), after recovery from anesthesia (TREC), every 60 min up to 360 min and 12 and 24 h after the block. The pupil diameter was evaluated at the same time points, excepted at T0. The maximum pupillary dilatation was observed in Lido group at T120 followed by Ropi at TREC, and Bupi and Levo at T30. All of the anesthetics maintained eye pressure within acceptable levels for normal dogs and significantly reduced tear production. Tear production returned earliest in group Lido, followed by Bupi, Ropi and Levo. The corneal sensitivity returned earliest in group Lido, followed by Ropi, Bupi and Levo. The retrobulbar block using the temporal inferior technique proved to be feasible and safe, although lubrication of the ocular surface is suggested. Key words: Bupivacaine, dogs, levobupivacaine, lidocaine, ropivacaine ResumoO objetivo deste estudo foi avaliar os efeitos oculares, a exequibilidade e qualidade do bloqueio retrobulbar pela técnica inferior temporal, em cães, com diferentes anestésicos locais empregando-se agulha epidural de Tuohy. Oito cães foram incluídos no experimento e cada um foi estudado quatro vezes, com intervalo de 15 dias entre os tratamentos: Lido -lidocaína a 2%; Ropi -ropivacaína a 0,5%, Bupi -bupivacaína racêmica a 0,5% e Levo -levobupivacaína a 0,75%. Com exceção da ropivacaína, todos os anestésicos continham epinefrina 1:200.000. Os bloqueios foram realizados nos olhos direitos dos animais imediatamente após a indução anestésica, e os olhos esquerdos, não bloqueados, foram utilizados como controle. Avaliou-se a pressão intraocular, a produção lacrimal e a sensibilidade corneal antes de qualquer procedimento (T0), 30 min após a medicação pré-anestésica (TMPA), 30 min após a indução anestésica (T30), após a recuperação da anestesia (TREC), a cada 60 min até 360 min e 12 e 24 h após o bloqueio. O diâmetro pupilar foi avaliado nos mesmos momentos, exceto no T0. A máxima dilatação pupilar foi observada no grupo Lido seguida pelos grupos Ropi, Bupi e Levo. Todos os anestésicos mantiveram a pressão ocular dentro dos níveis normais para cães e reduziram significativamente a produção lacrimal. A produção lacrimal reto...

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Levobupivacain in der Regionalanästhesie

Urbanek

Kapral

2006

Anaesthesist

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Levobupivacaine [S(-)bupivacaine], the levorotatory S-enantiomer of racemic bupivacaine, is commercially available in the U.S. and in most European countries. We performed a systematic review (MEDLINE database) and identified 88 articles on the clinical application of levobupivacaine in more than 3,000 patients. The use of levobupivacaine is described for epidural, caudal, and spinal anesthesia, for peripheral nerve blocks, for ophthalmic and dental anesthesia, for different pediatric indications and for intravenous regional anesthesia. In these regional techniques, levobupivacaine was used for all common indications in a wide range of clinical settings. Epidural levobupivacaine was combined with fentanyl, morphine, sufentanil, epinephrine, and clonidine, spinal levobupivacaine was combined with sufentanil, fentanyl, and epinephrine. In most studies, levobupivacaine was compared to bupivacaine and/or ropivacaine.

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Bupivacaína racêmica, levobupivacaína e ropivacaína em anestesia loco-regional para oftalmologia: um estudo comparativo

Abstract: Considering the advanced age of most of these patients and the high concentrations of local anesthetics used in peribulbar blockade, the use of ropivacaine and levobupivacaine produces motor blockade as effective as racemic bupivacaine while minimising risks for cardiotoxicity.

Cited by 13 publications

References 12 publications

Anestesia peribulbar com ropivacaína: estudo da ação vasoconstritora

Anestesia peribulbar com ropivacaína: estudo da ação vasoconstritora

Ocular effects of retrobulbar block with different local anesthetics in healthy dogs

Levobupivacain in der Regionalanästhesie

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