Objective:The study was performed to determine the quality of life and factors affecting the quality of life of elderly nursing home residents. Methods: This cross-sectional study was conducted with 150 elderly individuals residing in nursing homes situated in Istanbul in the period December 2013-February 2014. Data were collected using the sociodemographic questionnaire and World Health Organization Quality of Life Scale(WHO-QOL-BREF). Descriptive statistics, Mann-Whitney U test, Kruskal-Wallis test, one way ANOVA, student's t-test, and multiple regression analysis were performed. Results: The mean age of elderly nursing home residents was 72.31±6.22 years. The mean score of the physical health domain was found to be statistically significantly higher in male elderly nursing home residents than in female elderly nursing home residents. The mean scores of the physical health, social relationship, and environment domains were found to be statistically significantly higher in elderly nursing home residents without chronic diseases than in those with chronic diseases. Moreover, the mean score of the physical health domain was found to be statistically significantly higher in elderly nursing home residents who did not have pain than in those who did have pain. The mean scores of the physical health, environment, and psychological domains were found to be statistically significantly higher in elderly nursing home residents who were not concerned about health than in those who were concerned about health. The mean scores of the physical health, social relationship, and psychological domains were found to be statistically significantly higher in elderly nursing home residents who consumed fruits and vegetables than in those who did not consume fruits and vegetables. The mean scores of the physical health and social relationship domains were found to be statistically significantly higher in elderly nursing home residents who exercised than in those who did not exercise. The mean scores of the physical health, environment, psychological, and social relationship domains were found statistically significantly higher in elderly nursing home residents who had a good relationship with friends, did not feel lonely, and were satisfied to stay in a nursing home than in other elderly individuals (p<0.05). Conclusion: It was observed that if elderly nursing home residents did not have pain, had a good relationship with friends, consumed fruits and vegetables, and were satisfied to stay in a nursing home, they had a better quality of life in terms of physical health, and if they had a good relationship with friends, had frequent visitors, and did not have chronic diseases, they Veriler tanımlayıcı istatistikler, Mann Whitney U testi, Kruskal Wallis testi, One-way Anova, student t testi ve çoklu regresyon analizi kullanılarak değerlendirildi. Bulgular: Araştırmaya katılan bireylerin yaş ortalaması 72,31±6,22'dir. Erkeklerin bedensel sağlık alt boyut puan ortalaması, kadınlara göre, kronik hastalığı olmayanların bedensel sağlık, sosy...