Tramadol effects on clinical variables and the mechanical nociceptive threshold in horses

Franco, Leandro Guimarães; Moreno, Juan Carlos Duque; Neto, Antônio Raphael Teixeira; Souza, Moisés Caetano e Escola de Veterinária e Zootecnia; Silva, Luiz Antônio Franco da Escola de Veterinária e Zootecnia

doi:10.1590/s0103-84782014000300021

Cited by 7 publications

(3 citation statements)

References 19 publications

(25 reference statements)

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“…It has highly variable oral bioavailability in horses [145][146][147][148][149][150]. The analgesic effects in experimental models of lameness have been inconsistent [104,146,151] such that no recommendations can currently be made about its use. Tapentadol has been shown to have more reliable pharmacokinetics in humans and may prove to be a more useful analgesic agent in the horse [152].…”

Section: Tramadolmentioning

confidence: 99%

BEVA primary care clinical guidelines: Analgesia

Bowen

Redpath

Dugdale

et al. 2019

Equine Veterinary Journal

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Summary Primary care guidelines provide a reference point to guide clinicians based on a systematic review of the literature, contextualised by expert clinical opinion. These guidelines develop a modification of the GRADE framework for assessment of research evidence (vetGRADE) and applied this to a range of clinical scenarios regarding use of analgesic agents. Key guidelines produced by the panel included recommendations that horses undergoing routine castration should receive intratesticular local anaesthesia irrespective of methods adopted and that horses should receive NSAIDs prior to surgery (overall certainty levels high). Butorphanol and buprenorphine should not be considered appropriate as sole analgesic for such procedures (high certainty). The panel recommend the continuation of analgesia for 3 days following castration (moderate certainty) and conclude that phenylbutazone provided superior analgesia to meloxicam and firocoxib for hoof pain/laminitis (moderate certainty), but that enhanced efficacy has not been demonstrated for joint pain. In horses with colic, flunixin and firocoxib are considered to provide more effective analgesia than meloxicam or phenylbutazone (moderate certainty). Given the risk of adverse events of all classes of analgesic, these agents should be used only under the control of a veterinary surgeon who has fully evaluated a horse and developed a therapeutic, analgesic plan that includes ongoing monitoring for such adverse events such as the development of right dorsal colitis with all classes of NSAID and spontaneous locomotor activity and potentially ileus with opiates. Finally, the panel call for the development of a single properly validated composite pain score for horses to allow accurate comparisons between medications in a robust manner.

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Section: Tramadolmentioning

confidence: 99%

BEVA primary care clinical guidelines: Analgesia

Bowen

Redpath

Dugdale

et al. 2019

Equine Veterinary Journal

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“…A motilidade intestinal foi avaliada pelo método de auscultação abdominal após a administração do tramadol, pela via intravenosa, na dose de 2,0mg/kg, e constatou-se diminuição dos escores de movimentos intestinais nos primeiros 60 minutos (Franco et al, 2014). No presente estudo, com dose inferior e via de administração diferente, não foi observada alteração significativa na avaliação objetiva do trânsito intestinal.…”

Section: Resultsunclassified

A influência da morfina ou tramadol pela via epidural no trânsito gastrintestinal de equinos

Bertonha

Valadão

Cruz³

et al. 2018

Arq. Bras. Med. Vet. Zootec.

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RESUMO Os opioides são utilizados na medicina veterinária na analgesia dos animais, porém há restrição quanto ao uso desses fármacos em equinos, pois podem desencadear alterações gastrintestinais, mas a administração pela via epidural minimiza os efeitos adversos. Assim, oito equinos hígidos foram utilizados em três grupos experimentais, objetivando-se avaliar a influência no trânsito gastrintestinal da injeção epidural de morfina (0,2mg/kg), tramadol (1,0mg/kg) ou NaCl 0,9%. Para a avaliação do trânsito gastrintestinal, foi administrada a lignina purificada e enriquecida (Lipe®), pela via oral, a qual posteriormente foi analisada nas fezes. As fezes foram coletadas para investigação desse marcador, antes da epidural e em intervalos até totalizar 48 horas do início do experimento. Os dados foram submetidos à análise de variância (ANOVA) de uma via, com repetições múltiplas. As médias entre cada momento dos grupos e dos momentos dentro de cada grupo foram comparadas pelo teste de Student-Newman-Keuls (P≤0,05). A morfina ou o tramadol administrados pela via epidural não alteraram o tempo médio de retenção da fase líquida, a taxa de passagem e o tempo de trânsito do marcador utilizado. Diante de tais achados, conclui-se que a morfina ou o tramadol pela via epidural não alteram o trânsito gastrintestinal.

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“…Quantitative pain assessment could be done using equipments like digital force gauge algometer, anaesthesiometer and WAGNER Pain Test TM Algometer. Pressure algometry has been proven to be a valid measure of localized pain in muscle, joints, tendons, ligaments and bones (Franco et al, 2014; Manufacturer's guide). Hence, Pain Test TM Algometer produced by WAGNER were used to test for pain threshold, tolerance and monitor the treatment progress by pressure algometry at different point of incision.…”

mentioning

confidence: 99%

Analgesic effect of Sansevieria longiflora (Sim) water extract and xylocaine cream on surgical wound incision in rats

Kilani

Hassan

Fadason

et al. 2020

Bangladesh J. Sci. Ind. Res.

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Analgesic effect of Sansevieria longiflora (S. longiflora) on surgically created wound was studied. Phytochemical screening of the crude water extracts was carried out following standard procedures. Sansevieria longiflora leaves was heated and the sap was squeezed into a sample bottle to be used as it was traditional believed. Its water extract was also prepared following standard procedure. Four (4) albino rats consisting of 2 males and 2 females were used for the study. One centimeter full thickness skin incision was created on 4 different locations at the dorsal region of each rat under anaesthesia. Each of the 4 wounds created was topically treated once daily with S. longiflora sap (E), S. longiflora water extract (F), Physiological saline solution (C) and xylocaine cream (G). The treatment regimen was rotated in a clockwise direction on each rat. Pain perception was evaluated with an algometer at 6:00 GMT (morning) and 18:00 GMT (evening) from day 1 post surgery for 5 days. The phytochemical studies revealed that S. longiflora contains carbohydrates, glycoside, saponins, steroids, triterpenes, flavonoids, alkaloids and tannins. Day1 after the surgery, the mean morning value of force (N) required to elicit pain in xylocaine treated wounds (5.2 ± 0.79) were significantly higher (p<0.001) than that of physiological saline solution (2.8 ± 0.29) whereas, not different from that of S. longiflora sap (4.48 ± 0.57) and water extract (4.2 ± 0.6). Similarly, on the day 5 after the surgery, the mean morning value of force (N) required to elicit pain in xylocaine treated wounds were significantly higher (p<0.0001) than that of physiological saline solution (PSS) treated wounds and not different from that of S. longiflora sap and water extract. This showed that S. longiflora sap and water extract possess analgesic effect on incisional wounds. This study serves as a preliminary study on this plant towards searching for potent analgesics that could be used for procedural pain management. Bangladesh J. Sci. Ind. Res.55(2), 99-106, 2020

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Tramadol effects on clinical variables and the mechanical nociceptive threshold in horses

Abstract: This study assessed the clinical effects and the mechanical antinociceptive potential of intravenous (IV) tramadol in horses.A blinded and randomized study was designed with

Cited by 7 publications

References 19 publications

BEVA primary care clinical guidelines: Analgesia

BEVA primary care clinical guidelines: Analgesia

A influência da morfina ou tramadol pela via epidural no trânsito gastrintestinal de equinos

Analgesic effect of Sansevieria longiflora (Sim) water extract and xylocaine cream on surgical wound incision in rats

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