Environmental risk factors related to the development of canine non-Hodgkin's lymphoma

Zanini, Danielle Almeida; Kimura, Katia Cristina; Nishiya, Adriana Tomoko; Ubukata, Rodrigo; Leandro, Rafael Magdanelo; Brito, Claudia Prado de; Trombetti, Márcia; Lagoa, Ana Carolina; Macedo, Thaís Rodrigues; Rodrigues, Lucas Campos de Sá; Rosendo, Janaína Aparecida da Silva; Arndt, Helen Lyrio; Dias, Ricardo Augusto; Dagli, M.L.

doi:10.1590/s0103-84782013005000089

Cited by 13 publications

(13 citation statements)

References 24 publications

(26 reference statements)

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“…The potential links between environmental pollutants and the risk of developing human NHL [ 24 , 31 ] and canine lymphomas [ 6 , 20 , 21 , 53 ] have been described. There is, however, a lack of studies relating environmental factors to the biological behavior of canine lymphomas, particularly those with potential prognostic or predictive value.…”

Section: Discussionmentioning

confidence: 99%

“…One of these factors is the exposure to cigarette smoking, which represents a risk factor primarily for follicular lymphomas in human patients[ 26 ]. Some studies have shown different risk factors for the development of canine lymphomas such as breed [ 27 ], sex and hormonal exposure[ 28 ], Bartonella infection [ 29 ], oxidative stress [ 30 ], household chemicals [ 6 , 31 ], herbicides [ 32 ], magnetic fields[ 33 ], and air pollution [ 5 , 19 - 21 , 34 ]. It is noteworthy, though, that no environmental factors were related to the biological behavior of spontaneous canine lymphomas.…”

Section: Introductionmentioning

confidence: 99%

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Immunocytochemical study of canine lymphomas and its correlation with exposure to tobacco smoke

Pinello¹,

Santos²,

Leite-Martins³

et al. 2017

Vet World

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Aim:Canine lymphoma is one of the most common canine neoplasms, but little is known regarding the effects of exposure to tobacco smoke on their biologic behavior. As cytology is the most frequent diagnostic method of canine lymphoma, the aims of this study were to perform an immunocytochemical study of canine lymphomas, including subtyping and cell proliferation analysis, and to establish their correlation with tobacco smoke exposure.Materials and Methods:A total of 23 dogs diagnosed with lymphoma were subjected to careful fine-needle biopsies of enlarged lymph nodes. The smears were air-dried, fixed with cold acetone, and immunocytochemically stained using CD3, PAX5, and Ki-67. Owners were requested to complete an epidemiologic questionnaire.Results:According to the updated Kiel classification, 65% were B-cell lymphomas - three low grade (LG) and 12 high grade (HG) and 35% were T-cell -two LG and six HG. Thirteen tumors presented high Ki67 indexes (>40%) (11 HG and 2 LG), two revealed moderate ones (20-40%) (1 HG and 1 LG), and three had low indexes (≤20%) (1 HG and 2 LG). Both a significant positive correlation and a significant linear-by-linear association (p=0.018) were observed between high Ki67 indexes and smoking owners (r=0.753, p=0.002) as well as with the number of smokers in the household (r=0.641, p=0.001). Moreover, the mean percentage of Ki67+ cells from the group of “smoker owners” was statically higher (p=0.011) than that from the “non-smoker owners.”Conclusion:The results suggest that cytological diagnosis of canine lymphomas benefits from being complemented with immunocytochemical studies that include subtyping and assessment of proliferative activity, both contributing for the prognosis and therapeutic planning. Furthermore, exposure to tobacco smoke seems to be related to the biological behavior of canine lymphomas.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Immunocytochemical study of canine lymphomas and its correlation with exposure to tobacco smoke

Pinello¹,

Santos²,

Leite-Martins³

et al. 2017

Vet World

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“…Estudos realizados por Zanini et al (2013) A forma multicêntrica é frequentemente relatada como sendo a apresentação anatômica mais comum em cães com linfomas (Dobson e Gorman, 1993;Cardoso et al, 2003;Kimura et al, 2011), fato comprovado por Borges et al (2015) em estudo realizado no estado de Pernambuco em 15 animais diagnosticados com linfoma, destes 13 (86,6%) foram classificados anatomicamente em multicêntrico, assim como o caso aqui apresentado.…”

Section: Descrição Do Casounclassified

Linfoma imunoblástico em cão

et al. 2017

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ResumoObjetivou-se com este trabalho relatar um caso de linfoma imunoblástico em uma cadela diagnosticado pelo exame citopatológico. Analisou-se um animal da espécie canina, fêmea, sem raça definida, cinco anos de idade, procedente do Hospital Veterinário da Universidade Federal Rural de Pernambuco. De acordo com o histórico, o animal apresentou há aproximadamente três meses edema submandibular e em membros pélvicos que persistiam, com posterior aparecimento de nodulações nestas regiões, além de emagrecimento progressivo. Ao exame clínico foi constatado o aumento generalizado dos linfonodos superficiais e severa hipertrofia dos linfonodos submandibulares. Realizou-se a coleta de amostras dos linfonodos superficiais pela técnica de Citologia Aspirativa por Agulha Fina (CAAF), para diagnóstico citopatológico. A análise microscópica da amostra obtida pela CAAF revelou alta celularidade, presença de população de células de perfil linfocitário, compatíveis com imunoblastos, apresentando diâmetro nuclear variando entre uma e meia a duas hemácias, cromatina vesicular e nucléolo proeminente e central, citoplasma de basofilia leve a moderada. Foram observados também mitoses atípicas, acentuado pleomorfismo celular, anisocitose e anisocariose. Neste relato o linfoma foi anatomicamente classificado em multicêntrico. As alterações descritas ao exame citopatológico associadas ao histórico clínico do animal são compatíveis com linfoma imunoblástico de alto grau, sendo este o primeiro registro em um cão no estado de Pernambuco. A classificação citomorfológica associada a outros parâmetros pode propiciar ao médico veterinário um adequado direcionamento terapêutico, bem como auxiliar no estabelecimento do prognóstico.Palavras-Chave: canino; citopatologia; doenças linfoproliferativas; neoplasia. AbstractThe purpose of this study was to report a case of immunoblastic lymphoma in a dog diagnosed via cytopathology. A female, mix breed, five-year-old canine was seen at the Veterinary Hospital of the Federal Rural University of Pernambuco, Brazil. According to the history, the animal presented about three months prior with submandibular and pelvic limbs edema that persisted, with later appearance of nodulations in these regions, in addition to progressive weight loss. Clinical examination revealed a generalized increase in superficial lymph nodes and severe hypertrophy of submandibular lymph nodes. Samples of the superficial lymph nodes were collected using Fine Needle Aspiration Cytology (CAAF) for cytopathological diagnosis. The microscopic analysis of the sample obtained by CAAF revealed high cellularity, presence of lymphocytic cell population compatible with immunoblasts, with nuclear diameter ranging from one and a half to two red blood cells, vesicular chromatin and prominent and central nucleolus, cytoplasm of mild to moderate basophilia. Atypical mitoses, marked cellular pleomorphism, anisocytosis and anisokaryosis were also observed. In this report, the lymphoma was anatomically classified as multicentric. The changes descri...

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“…Studies, carried out worldwide, point out that chronic exposure to air pollution increases the risk of cancer (Cui et al, 2014;Jarrett et al, 2005;Portnov, et al, 2009;Vineis, et al, 2004), specifically lung cancer (Ames et al, 1995;Chakraborty, 2012;Cohen, 2000;Jarrett et al, 2013;Nyberg, et al, 2000;Zanini et al, 2013) and possibly also non-Hodgkin lymphomas (NHL). Elevated risks of lung cancer and NHL have been reported in the world's major metropolitan cities, such as Los Angeles, Trieste, and Toronto, especially among populations living in proximity to thoroughfare roads and industrial facilities (Al-Ahmadi and Al-Zahrani, 2013;Johnson et al, 2003;Nyberg, et al, 2000;Parodi et al, 2014;Ramis et al, 2009).…”

Section: Air Pollution and Cancermentioning

confidence: 99%

Application of the double kernel density approach to the analysis of cancer incidence in a major metropolitan area

Davarashvili

Zusman

Keinan‐Boker

et al. 2016

Environmental Research

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Environmental risk factors related to the development of canine non-Hodgkin's lymphoma

Abstract: This research aimed to investigate the possible risk factors associated with the development of canine non- (OR: 3,1, IC 95%: 1,(4)(5)(6)9, P=0,005

Cited by 13 publications

References 24 publications

Immunocytochemical study of canine lymphomas and its correlation with exposure to tobacco smoke

Immunocytochemical study of canine lymphomas and its correlation with exposure to tobacco smoke

Linfoma imunoblástico em cão

Application of the double kernel density approach to the analysis of cancer incidence in a major metropolitan area

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