Extrato hidroalcoolico da casca do pequi (Caryocar brasiliense) em ratos submetidos à aplicação de doxorrubicina

Moura, Léa Resende; Martins, Aparecida Conceição; Vaz, Liliam Aparecida da Rocha; Orpinelli, Stiwens Roberto Trevisan; Silva, Thiago Lopes da; Faleiro, Mariana Batista Rodrigues; Santos, Suzana C.; Moura, Veridiana Maria Briagnezi Dignani de

doi:10.1590/s0103-84782013000100017

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…Comparing C. coriaceum fruit part extracts, the pulp presented significantly higher antioxidant potential. Regarding the capacity of scavenging free radicals of the extracts, pulp and peel of C. coriaceum fruit showed a better action than that obtained in other plant extracts reported by Moura et al [ 33 ], Penido et al [ 20 ], and Morais et al [ 10 ].…”

Section: Resultsmentioning

confidence: 68%

Flavonoid Composition and Biological Activities of Ethanol Extracts of Caryocar coriaceum Wittm., a Native Plant from Caatinga Biome

Alves

Morais

Tomiotto-Pellissier

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Caryocar coriaceum fruits, found in Brazilian Cerrado and Caatinga, are commonly used as food and in folk medicine, as anti-inflammatory, bactericide, fungicide, leishmanicide, and nematicide. Due to the biological potential of this plant, this study focuses on the evaluation of antifungal and antileishmanial activities, including anticholinesterase and antioxidant tests, correlating with total phenols and flavonoids content. Peel extracts contain higher yield of phenols and flavonoids as analyzed by spectrophotometric methods. HPLC analysis of flavonoids revealed that isoquercitrin is the main flavonoid in both parts of the fruit, and peel extract showed the best antioxidant activity. In the inhibition of the acetylcholinesterase assay, both extracts demonstrate action comparable to physostigmine. The antimicrobial activity of extracts was evaluated against strains of Malassezia sp. and Microsporum canis, using the broth microdilution technique, in which the extracts showed similar MIC and MFC. The extracts present antileishmanial activity and low toxicity on murine macrophages and erythrocytes. Therefore, these results suggest a potential for the application of C. coriaceum fruit's ethanol extracts in the treatment against dermatophyte fungi and leishmaniasis, probably due to the presence of active flavonoids. Further in vivo studies are recommended aiming at the development of possible new pharmaceutical compounds.

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Section: Resultsmentioning

confidence: 68%

Flavonoid Composition and Biological Activities of Ethanol Extracts of Caryocar coriaceum Wittm., a Native Plant from Caatinga Biome

Alves

Morais

Tomiotto-Pellissier

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…Like any chemotherapy drug, doxorubicin has adverse effects, including a dosedependent cardiotoxic effect [9,12,13]. This toxicity is related to the release of free radicals, which are responsible for oxidative stress, leading to lipid peroxidation, protein degradation and cell membrane damage by proteins, carbohydrates and DNA radicals, among other adverse effects [14]. Cyclophosphamide is an alkylating agent in the oxazaphosphorine group that has cytotoxic and immunosuppressive activities [15,16].…”

Section: Introductionmentioning

confidence: 99%

Comparative Effect of Maitake Pro4x with Chemotherapy Breast Cancer Treatment

Braico¹,

Roldan-Deamicis²,

Brie³

et al. 2017

Biol Med (Aligarh)

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Background: Conventional treatments for breast cancer involve surgery followed by radiation and hormonal therapy and/or chemotherapy. Some of these treatments have toxic side effects. Because drugs used in chemotherapy affect both cancer and normal cells to varying degrees, researchers are currently developing targeted drugs that only attack cancer cells without affecting normal cells. One approach to this is to found compounds that are more selective and specific, destroying only tumour cells and prevent metastases without harming normal cells. For thousands of years, medicinal mushrooms have been used because of their healing properties. Maitake (Grifola frondosa) is one of the most promising edible and medicinal mushroom, acting promoting the immune system against the tumorigenesis process.

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Extrato hidroalcoolico da casca do pequi (Caryocar brasiliense) em ratos submetidos à aplicação de doxorrubicina

Cited by 2 publications

References 12 publications

Flavonoid Composition and Biological Activities of Ethanol Extracts of Caryocar coriaceum Wittm., a Native Plant from Caatinga Biome

Flavonoid Composition and Biological Activities of Ethanol Extracts of Caryocar coriaceum Wittm., a Native Plant from Caatinga Biome

Comparative Effect of Maitake Pro4x with Chemotherapy Breast Cancer Treatment

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