Extratos de Moringa oleifera e Vernonia sp. sobre Candida albicans e Microsporum canis isolados de cães e gatos e análise da toxicidade em Artemia sp.

Rocha, Marcos Fábio Gadelha; Aguiar, F.L.N.; Brilhante, Raimunda Sâmia Nogueira; Cordeiro, Rossana de Aguiar; Teixeira, Carlos Eduardo Cordeiro; Castelo-Branco, Débora de Souza Collares Maia; Paiva, Manoel de Araújo Neto; Zeferino, João P. O.; Mafezoli, Jair; Sampaio, Célia Maria de Souza; Barbosa, Francisco Geraldo; Sidrim, José Júlio Costa

doi:10.1590/s0103-84782011001000022

Cited by 10 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The plants from the genus Vernonanthura are widely used, especially the leaves and roots, in cases of flu, colds, cough, bronchitis, bruises, hemorrhoids, rheumatism, hepatic colic, bleeding, and uterine infections [ 17 , 21 ]. Studies show the potential of this plant as a therapeutic alternative with anti-inflammatory, antimicrobial, antifungal, insecticidal, antioxidant, immunomodulatory, anthelmintic, antinociceptive, and antiprotozoal action [ 12 , 18 , 22 , 23 , 24 , 25 ]. Some studies also report the activity of the essential oil of V. brasiliana against L. amazonensis , L. infantum , and L. donovani promastigotes [ 23 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Characterization and Leishmanicidal Activity In Vitro and In Silico of Natural Products Obtained from Leaves of Vernonanthura brasiliana (L.) H. Rob (Asteraceae)

et al. 2023

View full text Add to dashboard Cite

Vernonanthura brasiliana (L.) H. Rob is a medicinal plant used for the treatment of several infections. This study aimed to evaluate the antileishmanial activity of V. brasiliana leaves using in vitro and in silico approaches. The chemical composition of V. brasiliana leaf extract was determined through liquid chromatography-mass spectrometry (LC-MS). The inhibitory activity against Leishmania amazonensis promastigote was evaluated by the MTT method. In silico analysis was performed using Lanosterol 14alpha-demethylase (CYP51) as the target. The toxicity analysis was performed in RAW 264.7 cells and Tenebrio molitor larvae. LC-MS revealed the presence of 14 compounds in V. brasiliana crude extract, including flavonoids, flavones, sesquiterpene lactones, and quinic acids. Eriodictol (ΔGbind = −9.0), luteolin (ΔGbind = −8.7), and apigenin (ΔGbind = −8.6) obtained greater strength of molecular interaction with lanosterol demethylase in the molecular docking study. The hexane fraction of V. brasiliana showed the best leishmanicidal activity against L. amazonensis in vitro (IC50 12.44 ± 0.875 µg·mL−1) and low cytotoxicity in RAW 264.7 cells (CC50 314.89 µg·mL−1, SI = 25.30) and T. molitor larvae. However, the hexane fraction and Amphotericin-B had antagonistic interaction (FICI index ≥ 4.0). This study revealed that V. brasiliana and its metabolites are potential sources of lead compounds for drugs for leishmaniasis treatment.

show abstract

Section: Introductionmentioning

confidence: 99%

Chemical Characterization and Leishmanicidal Activity In Vitro and In Silico of Natural Products Obtained from Leaves of Vernonanthura brasiliana (L.) H. Rob (Asteraceae)

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Humans have always used plants for therapeutic purposes to control microbial infections and other medical conditions (Rangel et al, 2001). The increase of bacterial and fungal infections and the development of microbial resistance to synthetic drugs have led to renewed interest in recent years to investigate plants as natural sources of substances for therapy against microorganisms of medical and veterinary importance (Denning, 2002;Rocha et al, 2011;Nascimento et al, 2000;Bautista-Baños et al, 2003). Numerous plants have been used for prophylactic purposes and to cure infections.…”

Section: Introductionmentioning

confidence: 99%

A review on antimicrobial potential of species of the genus Vernonia (Asteraceae)

Sobrinho¹,

Souza²,

Fontenelle³

2015

J. Med. Plants Res.

View full text Add to dashboard Cite

Natural products are sources of various biologically active chemicals. Therefore, ethnopharmacological and ethnobotanical studies are essential to discover new substances for the treatment of diseases. In this context, many studies have been conducted of the Asteraceae family demonstrating medicinal properties of its representatives, such as species of the genus Vernonia, which are rich in bioactive substances like sesquiterpene lactones, flavonoids, tannins and steroids. This review presents an overview of Vernonia species with antimicrobial potential, their main phytochemical characteristics and ethnomedicinal uses.

show abstract

Natural Compounds Extracted from Moringa oleifera and Their Agricultural Applications

Khairulmazmi

Tijjani

2019

Natural Bio-Active Compounds

View full text Add to dashboard Cite

Natural bio-active compounds synthesized by plants as secondary metabolites are well known and established. Today, their application in various fields such as medicine in the form of drugs and biopesticides in agriculture is well documented. In recent times, the delivery of such compounds is achieved through nanodelivery technology, which is gaining acceptability in both field of drugs and agrochemical industries. The bio-active compounds with chemical diversity are obtained from nature either as homogenous plant crude extracts or as purified compounds. Crude plant extracts exist as a combination of different bio-active compounds with various polarities, and their partition remains a challenge in the process of characterization and identification. Extraction of these compounds from plant species is achieved by different solvents and extraction methods. Analytical methods like HPLC have commonly been utilized with GC-MS and LC-MS/MS chromatography methods to identify the compounds. Crude extracts from different morphological parts of plant species including Moringa oleifera are increasingly becoming important in the context of agricultural pest management and human medicine. M. oleifera is a medicinal plant that synthesizes such metabolites which include phenolic acids, carotenoids, quinones, antraquinones, flavonoids, flavonols, flavones, tannins, alkaloids, coumarins, terpenoids, amines, cyanogenic glycosides, triterpenoids, non-protein amino acids, glucosinolates, polyacetylenes, polyketides, phenylpropanes, steroids and saponins. They exert biological activities and can potentially be used to retard microbial activities. Other uses of M. oleifera are medicinal uses and other purposes such as water purification, fertilizer, biogas and biopesticides. The aim of this chapter is to highlight the uses and profiling of bio-active compounds of M. oleifera, their mode of action and prospects in commercial biopesticides for agricultural applications.

show abstract

Extratos de Moringa oleifera e Vernonia sp. sobre Candida albicans e Microsporum canis isolados de cães e gatos e análise da toxicidade em Artemia sp.

Abstract: II1Extratos de Moringa oleifera e Vernonia sp. sobre Candida albicans e Microsporum canis isolados de cães e gatos e análise da toxicidade em Artemia sp.

Cited by 10 publications

References 16 publications

Chemical Characterization and Leishmanicidal Activity In Vitro and In Silico of Natural Products Obtained from Leaves of Vernonanthura brasiliana (L.) H. Rob (Asteraceae)

Chemical Characterization and Leishmanicidal Activity In Vitro and In Silico of Natural Products Obtained from Leaves of Vernonanthura brasiliana (L.) H. Rob (Asteraceae)

A review on antimicrobial potential of species of the genus Vernonia (Asteraceae)

Natural Compounds Extracted from Moringa oleifera and Their Agricultural Applications

Contact Info

Product

Resources

About