A review on antimicrobial potential of species of the genus Vernonia (Asteraceae)

Sobrinho, Antonio Carlos Nogueira; Souza, Elnatan Bezerra de; Fontenelle, Raquel Oliveira dos Santos

doi:10.5897/jmpr2015.5868

Cited by 13 publications

(5 citation statements)

References 83 publications

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“…27 It has a wide folkloric use against diverse diseases. More importantly, it has gained wide application in the management of wound, [28][29][30][31][32][33] and other medicinal uses such as relieve of headache, 34 antiplasmodial, [35][36][37][38][39] antibacterial, 34,40,41 diarrheal disease, [42][43][44][45] snake bite poison, [46][47][48][49] cataract, 40,50 toothache, 44 placenta removal, 33,51,52 skin cut/infection, [53][54][55] dermatitis, 56 febrile convulsion, 57 anti-trypanosomal, 33 endo/ ectoparasite, 58,59 cancer or tumour, 60 and eye infection and warts. 61 The volatile oil from the leaf, crude extracts, fractions, and isolated pure compounds were tested in vitro to evaluate antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Wound Healing Activity of Methanolic Crude Extract and Solvent Fractions of the Leaves of Vernonia auriculifera Hiern (Asteraceae) in Mice

Lambebo¹,

Kifle²,

Gurji³

et al. 2021

JEP

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Background Medicinal plants play an important role in treating various diseases. Vernonia auriculifera Hiern is one of the medicinal plants used traditionally for the management of wounds. However, there were no scientific reports documented so far on the wound healing activities to substantiate the claim. Thus, the present study provides a scientific evaluation for the wound healing potential of the crude extract as well as solvent fractions of the leaves of Vernonia auriculifera Hiern. Methods Extraction was carried out by maceration using 80% methanol and part of the crude extract fractionated with chloroform, ethyl acetate, and aqueous solvents. Simple ointment bases were prepared using hard paraffin, cetostearyl alcohol, white soft paraffin and wool fat according to British Pharmacopoeia. Then, two types of ointment formulations were prepared from the extract, ie, 5% w/w and 10% w/w. Mice and rats were employed for wound healing study and dermal toxicity test, respectively. Wound healing effects were evaluated by percent of wound contraction, period of epithelialization, tensile strength, and histological analysis as parameters in excision, incision, and burn wound models. Finally, the data were expressed as mean ± SEM, and the results were analyzed using one-way ANOVA followed by post hoc Tukey-test. Results In the excision wound model, the 10% w/w crude extract ointment showed significant wound contraction ( P < 0.001) from day 4 to day 18 as compared to the negative control. Both the 5% w/w ( P < 0.001) and 10% w/w ( P < 0.05) crude extract ointments have showed statistically significant difference in epithelialization period as compared to the negative control. Groups treated with the ethyl acetate and aqueous fractions ointments in incision wound model showed a statistically significant ( P < 0.001) increase in tensile. The 10% w/w and 5% w/w ointments of the crude extract showed a significant ( P < 0.001) increase in breaking strength compared to simple ointment and the untreated control groups. In burn wound model, significant reduction in epithelialization period was observed in 5% w/w ( P < 0.05) and 10% w/w ( P < 0.001), and the percentage of wound contraction was significantly increased in most of post wounding days by 10% w/w ( P < 0.001) and 5% w/w ( P < 0.05) crude extract ointments and compared to the negative control. Conclusion The crude, aqueous, and ethyl acetate fraction of Vernonia auriculifera leaves possess wound healing activities. This finding justifies the use of the leaves of this plant for wound healing as claimed in the traditional medicine literature.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Wound Healing Activity of Methanolic Crude Extract and Solvent Fractions of the Leaves of Vernonia auriculifera Hiern (Asteraceae) in Mice

Lambebo¹,

Kifle²,

Gurji³

et al. 2021

JEP

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“…Asteraceae, the biggest eudicotyledon family, is notable for its medicinal, cosmetic, and aromatic properties. 5 Several Vernonia species are used in herbal medicine to treat a variety of diseases. Different species of Vernonia have also been investigated experimentally revealing many properties such as anti-plasmodial, analgesic, anti-inflammatory, antimicrobial, antidiabetic, antioxidant, and antitumor.…”

Section: Introductionmentioning

confidence: 99%

“…Different species of Vernonia have also been investigated experimentally revealing many properties such as anti-plasmodial, analgesic, anti-inflammatory, antimicrobial, antidiabetic, antioxidant, and antitumor. 5 In Uganda and Kenya, cold water infusion of V. auriculifera is taken orally to relieve fever associated with bacterial and viral infections. 6 In Ethiopia, V. auriculifera , locally known as “Barewa”, is a known medicinal plant for wounds, fever reduction, hepatitis, headaches, venereal diseases, diabetes, and gastrointestinal problems.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Antioxidant and Wound Healing Properties of 80% Methanol Extract and Solvent Fractions of the Leaves of Vernonia auriculifera Hiern. (Asteraceae)

Ashenafi

Abula

Abay

et al. 2023

CCID

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Background The leaves of Vernonia auriculifera (Asteraceae) have traditionally been used to treat wounds in several regions of Ethiopia. The purpose of this study was to assess the wound healing properties of the leaf extract and solvent fractions of V. auriculifera in mice. The leaf extract and solvent fractions of V. auriculifera have also been evaluated for their anti-oxidant properties because of their impact on the wound healing process. Material and Methods Air-dried leaves were extracted using 80% methanol. They were also successively fractionated with n-hexane, ethyl acetate, and methanol. The residue was then macerated in water for 72 hr. Simple ointment bases were formulated according to British Pharmacopoeia. Thereafter, two types of ointment formulations, 2.5% w/w and 5% w/w, were formulated. Wound healing and acute dermal toxicity studies were performed on mice. To assess free radical scavenging activity, a 2,2-diphenyl-2-picrylhydrazyl free radical (DPPH) assay was performed. Results In both models, wounds treated with 2.5% and 5% (w/w) of the ME, the aqueous fraction (AQF), methanol fraction (MEF), and ethyl acetate fraction (EAF) ointments demonstrated significant wound healing activity, as shown by enhanced wound contraction, a shortened epithelialization time, increased hydroxyproline content, and enhanced tissue breaking strength. The extract and solvent fractions displayed free radical scavenging activity with IC50 values of 1.2 mg/mL, 1.46 mg/mL, 1.5 mg/mL, and 2.83 mg/mL for ME, AQF, MEF, and EAF, respectively, as compared to 1.42 mg/mL for ascorbic acid. Conclusion The result of this study indicates that 80% of methanol extract and solvent fractions are endowed with wound healing activity. Additionally, this study has also revealed that ME, AQF, MEF, and EAF have the capacity to scavenge free radicals. The study indicated that the wound healing effect could be attributed to the anti-inflammatory and antioxidant activities.

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“…It is an annual herb, erect and highly branched, it can grow up to a height of 80 cm, it is found mostly at the roadside, open waste places and dry grassy sites, among crop plantations (Ahsanul et al, 2012;Josh, 2014), and fallowed farm land. This genus is predominantly found in Africa, Asia and South America (Antonio et al, 2015). V. cinerea has many therapeutic applications in the practice of traditional medicine with every part of the plant used medicinally for treating ailments such as fevers, helminths, arthritis, diuresis, cancer, abortion, eye infection and various gastrointestinal disorders (Antonio et al, 2015;Verma, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…This genus is predominantly found in Africa, Asia and South America (Antonio et al, 2015). V. cinerea has many therapeutic applications in the practice of traditional medicine with every part of the plant used medicinally for treating ailments such as fevers, helminths, arthritis, diuresis, cancer, abortion, eye infection and various gastrointestinal disorders (Antonio et al, 2015;Verma, 2018). The plant is also used for smoking cessation, wound healing and eruptive boils (Sonibare et al, 2016) as well as quicker healing of accidental wounds (Rajendra and Abirami, 2012).…”

Section: Introductionmentioning

confidence: 99%

Pharmacognostic studies and thin layer chromatography profile of the aerial parts of Vernonia cinerealess. (Asteraceae)

ISA,

Adam,

Abdurahman

et al. 2023

jcbr

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Vernonia cinerea(VC) Less is synonymously known as Cyanthillium cinereum and Vernonia abbreviate belongs to Asteraceae family. Different parts of the plant are extensively used in traditional medicine for treatment of various disease conditions. However, there was no scientific evaluation of the plant’s pharmacognosy and thin layer chromatography (TLC), which necessitate these studies, to bring out characters that will facilitate its proper identification, standardization and, nature of secondary metabolites in aerial parts of the plant. To carry out detailed pharmacognostic studies and TLC evaluation on the aerial parts of Vernonia cinerea. Aerial plant parts of V. cinerea were studied for their organoleptic, macroscopic, microscopic, physicochemical features and bitterness properties, their elemental and nutritional values were evaluated using standard procedures. In the TLC, reagents were used to evaluate presence of various bioactive constituents in the parts studied. Pharmacognostic studies of aerial parts of VC highlighted features that are diagnostic from microscopic characters and their dimensions, different ergastic substances in the chemomicrocopical study. The elemental analysis showed the presence of macro, micro and trace elements. Nutritionally, there are presence of macro molecules such as carbohydrates, protein and fats. All these will serve as criteria to differentiate it from other species in the same and other families. The TLC profile showed spots of different colour shades after spraying with general and specific reagents and, their Rf values determined. Detailed pharmacognostic studies on the aerial parts of VC showed characters which might be useful to provide information with regard to its identification, standardization and types of phytochemicals present.

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A review on antimicrobial potential of species of the genus Vernonia (Asteraceae)

Cited by 13 publications

References 83 publications

Evaluation of Wound Healing Activity of Methanolic Crude Extract and Solvent Fractions of the Leaves of Vernonia auriculifera Hiern (Asteraceae) in Mice

Evaluation of Wound Healing Activity of Methanolic Crude Extract and Solvent Fractions of the Leaves of Vernonia auriculifera Hiern (Asteraceae) in Mice

Evaluation of the Antioxidant and Wound Healing Properties of 80% Methanol Extract and Solvent Fractions of the Leaves of Vernonia auriculifera Hiern. (Asteraceae)

Pharmacognostic studies and thin layer chromatography profile of the aerial parts of Vernonia cinerealess. (Asteraceae)

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