Adenocarcinoma pulmonar em um bovino

Viott, Aline de Marco; Langohr, Ingeborg M.; Vannucci, Fábio A.; Almeida, Arlindo; Leite, Rômulo Cerqueira; Ecco, Roselene

doi:10.1590/s0103-84782010005000014

Cited by 4 publications

(4 citation statements)

References 6 publications

(6 reference statements)

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“…In pancreatic adenocarcinomas, areas of hemorrhage, mineralization, or necrosis are also frequently present [8]. In the present study, metastases were found in the lymph nodes and greater omentum, and similar findings have been reported by Viott et al [16] and Santarosa et al [10].…”

Section: Discussionsupporting

confidence: 91%

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Primary Pulmonary Adenocarcinoma in a Cow

Neto¹,

Souto²,

Cajueiro³

et al. 2019

Acta Scientiae. Vet.

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Background: Primary neoplasms of the respiratory tract are rare in cattle, and they present with nonspecific clinical signs and are usually found at post-mortem. Pulmonary adenocarcinoma of the acinar type is uncommon, and information about this neoplasm in cattle is scarce. This paper aims to describe the clinical, laboratory, and pathological findings in a cow with this neoplasm.Case: A 10-year-old, adult, mixed-breed Holstein cow weighing 300 kg was referred to the Garanhuns Cattle Clinic of the Campus of Federal Rural University of Pernambuco, Brazil, with a history of decreased appetite, tiredness, weight loss, and difficulty in breathing for two months. The animal had been treated at the farm of origin with enrofloxacin, florfenicol, and flunixin meglumine. The animal’s appetite improved, but no improvement in the respiratory symptoms was observed. On examination at our center, the cow was in an orthopedic position, with neck extension and elbow abduction; and it remained in a recumbent position. The cow had neutrophilia, normochromic normocytic anemia, and hyperfibrinogemia. The body condition score (BCS) was 1 (BCS ranges from 1 to 5), and the cow had moderate enophthalmia, serous secretions in nostrils, tachycardia, and tachypnea. It also had increased breathing intensity; increased breath sounds in the cranial regions of both lungs; areas of reduced breath sounds in the medial portions of the lungs; intermittent wheezing in the cranial region of the left lung medially and in the cranial region of the right lung medially; intermittent crepitations in the cranial region of the right lung medially; reduced thoracic expansion; and expiratory dyspnea. Pulmonary ultrasonography revealed hyperechogenic multifocal structures in both lungs. In view of the severe clinical condition and unfavorable prognosis, the owner opted for euthanasia. Necropsy revealed that there was a significant amount of yellow fluid in the thoracic cavity, and the cut surfaces of the lungs were covered with fibrin and pleural adhesions. The lungs had irregular surfaces with multifocal nodules of various sizes and firm consistency. The texture of the cut nodules was solid, and the nodules had a yellowish color. Histologically, the pulmonary nodules were composed of neoplastic cells. They were pleomorphic, infiltrative epithelial cells with little cytoplasm; large and spherical nuclei with abundant euchromatin; occasional anisokaryosis; visible nucleolus; and numerous mitotic figures. Results of anti-cytokeratin immunohistochemistry were strongly positive for cytokeratin in the lungs and lymph nodes. Discussion: The diagnosis of acinar pulmonary adenocarcinoma was based on clinical, laboratory, histopathological, and immunohistochemical findings. Clinical signs and lung ultrasound suggested a severe respiratory disease. Pulmonary tumors are usually solid, and they show areas of central necrosis that resemble granulomas. However, the histopathological findings in the current case were compatible with a primary pulmonary neoplasm. Primary pulmonary neoplasms, although rare, should be considered in the differential diagnosis of weight loss, cachexia, and respiratory symptoms in adult cattle. The morphological pattern and the strong immunoreactivity on immunohistochemical examination were conclusive for a diagnosis of a primary pulmonary adenocarcinoma of the acinar type because these tumors specifically contain cytokeratin.

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Section: Discussionsupporting

confidence: 91%

“…The first detailed report of a pulmonary adenocarcinoma in a cow in Brazil was by Viott et al [16], and it was subsequently followed by reports by Sousa et al [12] and Santarosa et al [10]. Other cases have been reported in retrospective studies of neoplasms diagnosed during necropsies performed in veterinary hospitals [6,9].…”

Section: Introductionmentioning

confidence: 99%

Primary Pulmonary Adenocarcinoma in a Cow

Neto¹,

Souto²,

Cajueiro³

et al. 2019

Acta Scientiae. Vet.

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“…12 Although adenocarcinomas (ADs) are considered rare, these are the most frequent histological type reported in cattle. 5,46,60 Metastatic neoplasms may be more common, as observed in a study by Anderson and Sandinson 4 in which metastatic tumors were more than twice as frequent as primary tumors in cattle. In addition, reports of pulmonary metastases in cattle are frequent.…”

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confidence: 91%

Histological and immunohistochemical features of carcinomas with pulmonary involvement in cattle

Vielmo,

Santos,

Piva

et al. 2023

Vet Pathol

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Primary pulmonary neoplasms in cattle are rare. There are few studies on the pathological findings of these neoplasms in this species. This study aimed to describe the histological and immunohistochemical findings of primary and metastatic pulmonary carcinomas in cattle. We conducted a retrospective study of 19 cases of epithelial neoplasms with pulmonary involvement. Histologically, most of the neoplasms were classified as primary pulmonary neoplasms, including different adenocarcinoma subtypes (4/19, 21%) and adenosquamous carcinomas (3/19, 16%), followed by squamous cell carcinoma (6/19, 32%), metastatic uterine adenocarcinoma (4/19, 21%), metastatic hepatocellular carcinoma (1/19, 5%), and metastatic cholangiocarcinoma (1/19, 5%). By immunohistochemistry, all neoplasms were positive for pancytokeratin, and 4/19 (21%) were positive for vimentin. Primary pulmonary neoplasms had immunoreactivity for thyroid transcription factor-1 (6/7), while only 2 of these cases were positive for napsin A. All cases with squamous differentiation (9/9) had immunoreactivity for cytokeratin (CK) 5/6, while only 7 of these cases were positive for p40. CK20, CK7, and CK8/18 showed varied immunoreactivity in the primary and metastatic pulmonary carcinomas but were important markers to confirm the diagnosis of primary mucinous adenocarcinoma and metastatic cholangiocarcinoma. HepPar-1 was only positive in the metastatic hepatocellular carcinoma. The limited number of cases of metastatic uterine adenocarcinomas in this study precluded identification of a specific immunophenotype for this tumor. Immunohistochemistry proved to be an important tool to confirm the proper classification of these neoplasms.

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“…Os tumores primários do pulmão são considerados raros em bovinos e, quando ocorrem, são geralmente adenocarcinomas (Viott et al, 2010). No Brasil, casos foram descritos por Viott et al (2010), Lucena et al (2011), Sousa et al (2014) e Andrade Neto et al (2019).…”

Section: Introductionunclassified

Adenocarcinoma pulmonar associado à infecção por Mycobacterium sp. em vaca - relato de caso

Medeiros

Frade

Souto

et al. 2020

Arq. Bras. Med. Vet. Zootec.

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RESUMO Descrevem-se os aspectos clínicos, anatomopatológicos, imuno-histoquímicos, microbiológicos e moleculares de um caso de adenocarcinoma pulmonar associado à infecção por Mycobacterium sp. em uma vaca. O animal apresentou hiporexia, emagrecimento, vocalizações, postura ortopneica, ingurgitamento da jugular, estase venosa positiva, gemido expiratório e morte. Na necropsia, os pulmões estavam aumentados e apresentavam, na superfície pleural, nódulos branco-amarelados, firmes, multifocais a coalescentes, interpostos por áreas avermelhadas. Ao corte, os nódulos aprofundavam-se ao parênquima e possuíam múltiplos focos de aspecto caseoso e friável e áreas de mineralização. O saco pericárdico e os linfonodos traqueobrônquicos, ilíacos, lombares aórticos e mamários apresentavam lesões semelhantes. Histologicamente, observou-se neoformação carcinomatosa associada a áreas multifocais de necrose e mineralização. As células neoplásicas foram fortemente imunomarcadas pelo anticorpo antipancitoqueratina AE1/AE3. Na cultura microbiológica de fragmentos dos pulmões, houve crescimento de colônias bacterianas compatíveis com micobactérias atípicas. O sequenciamento molecular submetido ao BLASTn identificou o Mycobacterium sp. WCM 7299 (ID: gb|KJ873243.1|).

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Adenocarcinoma pulmonar em um bovino

Abstract: Pulmonary adenocarcinoma in a bovine RESUMO Um bovino Guzerá, fêmea, adulto, com

Cited by 4 publications

References 6 publications

Primary Pulmonary Adenocarcinoma in a Cow

Primary Pulmonary Adenocarcinoma in a Cow

Histological and immunohistochemical features of carcinomas with pulmonary involvement in cattle

Adenocarcinoma pulmonar associado à infecção por Mycobacterium sp. em vaca - relato de caso

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