Comparação de diferentes doses de colagenase em modelo de indução de tendinite para eqüinos: estudo clínico e ultra-sonográfico

Yamada, Ana Lúcia Miluzzi; Alves, Ana Liz Garcia; Hussni, Carlos Alberto; Nicoletti, José Luiz de Mello; Thomassian, Armen; Watanabe, Marcos Jun; Carneiro, Rodrigo Lima

doi:10.1590/s0103-84782009005000035

Cited by 5 publications

(9 citation statements)

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“…Ao ser aplicada no tendão flexor superficial, a colagenase promoveu dor à palpação de leve a intensa e claudicação de grau 1 a 3 em uma escala de 1 a 4 (FERNANDES et al, 2003;MARXEN et al, 2004;YAMADA et al, 2009). CAMINOTO (2003), ao injetar colagenase no LS, observou aumento de volume por três semanas e de sensibilidade e temperatura por duas semanas após a injeção.…”

Section: Resultsunclassified

“…Nos tendões flexores (YAMADA et al, 2009) ) no LS e não obteve sucesso, sendo necessária uma segunda aplicação, na dose de 0,5mL (5mg mL -1 ), no mesmo local da primeira aplicação.…”

Section: Introductionunclassified

“…Talvez em razão da ação enzimática contínua e da grande reação inflamatória promovida, as lesões produzidas por colagenase podem demorar até três semanas para estabilizar, havendo grande variação entre indivíduos e doses (CAMINOTO, 2003;YAMADA et al, 2009 Os objetivos do presente estudo foram propor um novo modelo para induzir lesão no LS equino, por meio da utilização de punch para biópsia cutânea, e avaliar, por meio de exames clínicos e ultrassonográficos, seus efeitos sobre os animais.…”

Section: Introductionunclassified

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Modelo de indução de lesão no ligamento suspensório equino com utilização de punch para biópsia cutânea

et al. 2010

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Modelo de indução de lesão no ligamento suspensório equino com utilização depunch para biópsia cutânea Suspensory ligament lesion model in horses using a skin biopsy punch RESUMO O objetivo deste estudo foi avaliar um novo modelo de lesão no ligamento suspensório (LS). INTRODUÇÃOO estudo das claudicações em equinos é uma das áreas de maior importância para a espécie, pois os problemas do sistema locomotor estão entre os mais comuns nos equinos. Entre as afecções mais frequentes, destaca-se a desmite do suspensório, uma enfermidade que acomete os membros torácicos e/ou pélvicos dos cavalos atletas. Grandes perdas econômicas ocorrem, pois o animal pode diminuir seu desempenho mesmo antes de os sinais clínicos se tornarem evidentes. Durante o longo período de tratamento, o animal necessita de repouso, ficando afastado de competições e treinamento. Alguns autores consideram que essa seja a maior causa de claudicação e perda da função nos cavalos atletas (HERTHEL, 2001

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Section: Resultsunclassified

“…Nos tendões flexores (YAMADA et al, 2009) ) no LS e não obteve sucesso, sendo necessária uma segunda aplicação, na dose de 0,5mL (5mg mL -1 ), no mesmo local da primeira aplicação.…”

Section: Introductionunclassified

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Modelo de indução de lesão no ligamento suspensório equino com utilização de punch para biópsia cutânea

et al. 2010

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“…Gillis (1997) observed that tendon enlargement culminates in adaptation to physical training. Yamada et al (2009) and Sousa et al (2021) agree that training is directly linked to an increase in the crosssectional area in some tendons and tendinous regions. The present work corroborates previous studies in some specific zones of evaluation: the increase of the DDFT is more accentuated and visible when at the end of the training.…”

Section: Discussionmentioning

confidence: 80%

Ultrasound evaluation of digital flexor tendons of jumping horses undergoing treadmill training

Buzzetti

Nothaft

Paganela³

et al. 2022

Braz. J. Vet. Med.

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This study aimed to perform ultrasonographic evaluation of the digital flexor tendons of jumping horses undergoing complementary training on a treadmill. Fifteen Brazilian Sport horses were divided into two groups: Group I with 7 animals in physical training complementary to the standard training at the Brazilian Army's Riding School; and Group II with 8 animals in standard training used in the Brazilian Army's Riding School. Complementary training was performed on a treadmill on an inclined plane. Ultrasonographic images were taken at the beginning and at the end of training. The left thoracic and pelvic limbs of horses were evaluated for echogenicity values and cross-sectional areas of the superficial digital flexor tendons (SDFTs) and deep digital flexor tendons (DDFTs) in zones IA, IIB, and IIIB. The mean areas of the SDFT were 93.7 mm 2 and 95.8 mm 2 at the beginning and the end of training, respectively. The cross-sectional area of DDFT increased from 124.6 mm 2 at the beginning of training to 136.8 mm 2 at the end of training. The echogenicity values of both tendons were between 0 and 1 as expected, concluding that clinically, the animals showed adaptation to the exercise protocol with no signs of tendon injury being detected, implying that traditional training and complementary training are safe.

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“…One way of inducing a tendon lesion that has been described in the literature is through the intratendinous application of collagenase at various doses. For example, 0.5 mL at a concentration of 2.5 mg/ mL [23,24] or 1.0 mL at a concentration of 2.5 mg/mL [25] has shown good results for lesion evolution, oedema formation and palpation sensitivity, with effects similar to the normal inflammatory process in the SDFT. However, this experimental model allows the collagenase to continue acting on the tissue for a long period of time, which makes it difficult to control the lesion [26].…”

Section: Discussionmentioning

confidence: 99%

Effect of phototherapy with light-emitting diodes (890 nm) on tendon repair: an experimental model in sheep

et al. 2014

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The effect of phototherapy with 890-nm light-emitting diodes (LEDs) on the healing of experimentally induced tendinitis in sheep was evaluated in this study. Partial tenotomies measuring 0.2 cm wide × 0.5 cm long were performed on the second third of the superficial digital flexor tendons of 10 healthy sheep. The animals were divided into two groups: "treated" (TG), treated with LEDs at the aforementioned wavelength, and "control" (CG), a control group treated with a placebo. Kinesiotherapy, which consisted of 5-min walks on grassy ground, was performed on both groups. B-mode and power Doppler ultrasonographies (US) were performed to evaluate the tendon healing process during the first 14 days after surgery and on the 21st and 28th postoperative days. Biopsies were performed on day 28 for the histopathological assessment of neovascularisation and the pattern of the tendon fibres. The absence of lameness and a significant improvement (p < 0.05) in the sensitivity to pain during palpation were observed in the treated group. Furthermore, a significant reduction in oedema and an increased number of vessels (p < 0.05) were observed in this group with the B-mode and power Doppler US, respectively. No significant difference in the evolution of the lesion was found. There was a histological difference (p < 0.05) in neovascularisation in the treated group. Phototherapy with 890-nm light-emitting diodes decreases the inflammatory process.

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Comparação de diferentes doses de colagenase em modelo de indução de tendinite para eqüinos: estudo clínico e ultra-sonográfico

Abstract: IComparação de diferentes doses de colagenase em modelo de indução de tendinite para equinos: estudo clínico e ultra-sonográfico

Cited by 5 publications

References 11 publications

Modelo de indução de lesão no ligamento suspensório equino com utilização de punch para biópsia cutânea

Modelo de indução de lesão no ligamento suspensório equino com utilização de punch para biópsia cutânea

Ultrasound evaluation of digital flexor tendons of jumping horses undergoing treadmill training

Effect of phototherapy with light-emitting diodes (890 nm) on tendon repair: an experimental model in sheep

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