Variáveis fisiológicas em cães submetidos à infusão contínua de diferentes doses de propofol

Ferro, P. C.; Nunes, Newton; Paula, Danielli Parrilha de; Nishimori, Celina Tie; Conceição, E. D. V.; Guerrero, Piedad Natalia Henao; Arruda, L. M.

doi:10.1590/s0103-84782005000500018

Cited by 11 publications

(14 citation statements)

References 11 publications

(13 reference statements)

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“…In PG, the stability of HR and CO corroborates data registered by Nunes et al (2008). According to Ferro et al (2005), in dogs breathing spontaneously, the continuous rate infusion of propofol (0.2; 0.4 and 0.8mg kg -1 minute -1 ) did not promote changes in heart rate.…”

Section: Discussionsupporting

confidence: 78%

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Intracranial variables in propofol or sevoflurane-anesthestized dogs subjected to subarachnoid administration of iohexol

Nunes

Leite²,

Paula³

et al. 2011

Arq. Bras. Med. Vet. Zootec.

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Intracranial variables in propofol or ABSTRACTThe effects of subarachnoid administration of iohexol on intracranial hemodynamic in dogs anesthetized with propofol or sevoflurane were evaluated. Thirty adult animals (10.92.9kg) were distributed into two groups: PG, where propofol was used for induction (100.5mg/kg), followed by a continuous rate infusion at 0.550.15mg/kg/hour, and SG, where sevoflurane was administered for induction (2.5 MAC) and for anesthetic maintenance (1.5 MAC). A fiberoptic catheter was implanted on the right superficial cerebral cortex to monitor intracranial pressure (ICP). After 30 minutes, cerebrospinal fluid (CSF) was collected at the cisterna magna and iohexol was injected. The measurements were performed before CSF collection (TA), after the iohexol injection (T0), and at 10-minute intervals (T10 to T60). Intracranial pressure decreased at T0 in SG. Cerebral perfusion pressure at T0 was higher than at TA, T50 and T60 in PG, but in SG, the mean value at T0 was higher than the ones from T20 to T60. Mean arterial pressure at T0 was higher than at TA in PG, while in SG, the values from T20 to T60 were lower than at T0. The heart rate at T60 was lower than at T0 in PG. Cardiac output at TA was lower than at T60 in SG. The cerebrospinal fluid collection and administration of iohexol promoted decrease in intracranial pressure in sevolflurane-anesthetized dogs and increase in cerebral perfusion pressure in propofol-anesthetized dogs.Keywords: anesthesia, dogs, cerebral autoregulation, myelography Palavras-chave: cão, anestesia, autoregulação cerebral, mielografia RESUMO Avaliaram-se os efeitos da administração subaracnóidea de iohexol sobre a hemodinâmica intracraniana em cães anestesiados com propofol ou sevofluorano. Trinta e dois animais (10,9±2,9kg) foram distribuídos em dois grupos: no GP, o propofol foi usado para indução, 100.5mg/kg, seguido por infusão contínua, 0,55±0,15mg/kg/min; no GS, o sevofluorano foi administrado para indução, 2,5 CAM, e manutenção, 1,5 CAM, da anestesia. O cateter de fibra óptica foi implantado na superfície direita do córtex cerebral para monitorar a pressão intracraniana (PIC). Após 30 minutos, o fluido cerebroespinhal (FCS) foi coletado da cisterna magna e o iohexol injetado. As mensurações ocorreram antes da coleta do FCS (TA), depois da injeção de iohexol (T0) e em intervalos de 10 minutos (T10 a T60

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Section: Discussionsupporting

confidence: 78%

“…In premedicated, debilitated or elderly animals, the dose can be reduced from 20 to 80% (Short and Bufalari, 1999). Ferro et al (2005) used, in dogs, continuous infusions ranging from 0.2 to 0.8mg/kg/minute.…”

Section: Introductionmentioning

confidence: 99%

Intracranial variables in propofol or sevoflurane-anesthestized dogs subjected to subarachnoid administration of iohexol

Nunes

Leite²,

Paula³

et al. 2011

Arq. Bras. Med. Vet. Zootec.

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“…A similar study by Cassu et al (2008) has shown that, after epidural injection of lidocaine alone or combined with fentanyl, temperature gradually decreased, but there was no clinical relevance to it. Furthermore, we cannot discard the influence of propofol, administered through constant rate infusion, on body temperature, which has been described in dogs (Ferro et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…In one retrospective study of 242 dogs and 23 cats, epidural anesthesia with morphine with or without bupivacaine has been associated with respiratory alterations that decreased P E´C O 2 and increased PaCO 2 (Troncy et al, 2002). On the other hand, propofol is known to cause respiratory depression, which will result in high PaCO 2 values (Ferro et al, 2005). According to the same author, this is an effect directly related to the infusion rate.…”

Section: Discussionmentioning

confidence: 99%

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Epidural levobupivacaine alone or combined with different morphine doses in bitches under continuous propofol infusion

Albuquerque¹,

Araújo²,

Ferreira³

et al. 2015

Arq. Bras. Med. Vet. Zootec.

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The aim of this study was to assess the cardiopulmonary, analgesic, adverse effects, serum concentration of cortisol and plasma levels of levobupivacaine and morphine in bitches undergoing propofol anesthesia and epidural analgesia with levobupivacaine alone or combined with morphine. This was a randomized 'blinded' prospective clinical study using 32 adult bitches weighing 9.8±4.1kg that were admitted for elective ovariohysterectomy. Twenty minutes after administration of acepromazine and midazolam, anesthesia was induced with propofol (4mg kg -1 ) and maintained by a continuous rate infusion (CRI). Each animal was randomly assigned to one of four epidural groups: GL = levobupivacaine alone (0.33mg kg -1 ); GLM0.1 = levobupivacaine and morphine (0.1mg kg -1 ); GLM0.15 = levobupivacaine and morphine (0.15mg kg -1 ); and GLM0.2 = levobupivacaine and morphine (0.2mg kg -1 ). Variables obtained during anesthesia were heart rate, respiratory rate, systolic, mean and diastolic arterial blood pressures, oxyhemoglobin saturation, inspired oxygen fraction, end-tidal carbon dioxide tension, blood gases, serum cortisol, and plasma levels of levobupivacaine and morphine. The onset and duration times of the blockade were recorded. Arterial pressures were significantly increased in all groups at the times of ovarian pedicle clamping. There was a decrease in pH, together with an increase in both PaO 2 and PaCO 2 over time. Serum cortisol levels were increased in TESu compared to TB, T30 and TR. Limb spasticity, muscle tremors, opisthotonos and diarrhea were observed in some animals during propofol infusion and ceased with the end of CRI. Reactions happened at different moments and lasted for different periods of time in each individual. Epidural with levobupivacaine alone or combined with morphine allowed for ovariohysterectomy to be performed under low propofol infusion rates, with minimal changes in cardiovascular variables and in serum cortisol levels. Adverse effects were observed in very few animals in each group. Keywords: dog, opioid, ovariohysterectomy, blood gas, regional anaesthesia (0,33mg/kg); GLM0,1 = levobupivacaína + morfina (0,1mg/kg); GLM0,15 = levobupivacaína + morfina (0,15mg/kg) e GLM0,2 = levobupivacaína + morfina (0,2mg/kg RESUMO Objetivou-se avaliar os efeitos cardiovasculares, analgésico, adversos, a concentração sérica de cortisol e os níveis plasmáticos de levobupivacaína e morfina em cadelas submetidas à infusão contínua de propofol e analgesia peridural com levobupivacaína isolada ou associada à morfina. Para tanto, realizou-se um estudo clínico prospectivo randomizado com 32 cadelas adultas pesando 9,8 ± 4,1kg, que foram submetidas à ovário-histerectomia eletiva. Vinte minutos após a administração de acepromazina e midazolam, os animais foram induzidos com propofol (4mg/kg) e mantidos por uma infusão contínua (CRI) do mesmo fármaco. Cada animal foi alocado aleatoriamente em um dos quatro grupos: GL = levobupivacaína isolada

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Propofol at Single Bolus and Continuous Rate Infusion Significantly Increases Serum Triglycerides, but not Cholesterol, In Healthy Bitches Undergoing Elective Ovariohysterectomy

Chagas¹,

Custodio²,

Gusmão³

et al. 2021

Topics in Companion Animal Medicine

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Variáveis fisiológicas em cães submetidos à infusão contínua de diferentes doses de propofol

Cited by 11 publications

References 11 publications

Intracranial variables in propofol or sevoflurane-anesthestized dogs subjected to subarachnoid administration of iohexol

Intracranial variables in propofol or sevoflurane-anesthestized dogs subjected to subarachnoid administration of iohexol

Epidural levobupivacaine alone or combined with different morphine doses in bitches under continuous propofol infusion

Propofol at Single Bolus and Continuous Rate Infusion Significantly Increases Serum Triglycerides, but not Cholesterol, In Healthy Bitches Undergoing Elective Ovariohysterectomy

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