Síndrome hipereosinofílica idiopática associada à doença eosinofílica disseminada em um cão

Fighera, Rafael A.; Souza, Tatiana Mello de; Kommers, Gláucia D.; Barros, Claudio S.L.

doi:10.1590/s0103-84782004000300045

Cited by 2 publications

(4 citation statements)

References 7 publications

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“…The thickening of the intestinal mucosa, with an irregular surface and nodulation formation, in addition to a reactive hyperplasia in regional lymph nodes can be observed in the abdominal ultrasound of dogs with IHES (RODRIGUEZ et al, 1995). These formations correspond to granulomas composed of mature and immature eosinophil infiltrates with notorious fibroplasia (FIGHERA et al, 2004). Thickening of the intestinal wall occurs when the submucosal and muscular layers are replaced by granulomatous tissue.…”

Section: Discussionmentioning

confidence: 99%

“…However, the search for the histological finding of eosinophilic infiltrate in the viscera and/or involved structures, in association with clinical-epidemiological aspects, blood, spinal and imaging alterations, in addition to the absence of underlying diseases, is recommended for the definitive IHES diagnosis (LILLIEHOOK;TVEDTEN, 2003;FIGHERA et al, 2004). Despite the lack of a histopathological analysis for the reported case, the congregation of epidemiological, clinical, hematological, cytological, and ultrasonographic data led to the diagnostic suspicion for IHES, which confirmation was obtained with satisfactory therapeutic results.…”

Section: Discussionmentioning

confidence: 99%

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Clinical, laboratory and therapeutic aspects of canine idiopathic hypereosinophilic syndrome: case report

Silva¹,

Ferreira²,

Fernandes³

et al. 2018

AVB

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Article historyThe idiopathic hypereosinophilic syndrome (IHES) is a rare disease, characterized by variable eosinophilia and its massive infiltration into various organs. This study aimed to report clinical-laboratory findings and therapy in a canine with IHES. A one-year, 10-month-old male Rottweiler dog had a history of emesis, weight loss, hyporexia, and persistent eosinophilia on prior hematological exams. Vaccinations and worming were up to date. A complete blood count, serum biochemistry, bone marrow cytology, serology for leishmaniasis, chromatographic immunoassay for the detection of Dirofilaria immitis antigen, and abdominal ultrasound were requested. The tests for infectious diseases were negative. Blood biochemistry revealed no significant changes. An intense eosinophilia was observed in the hematology. A large number of cell precursors of the eosinophilic lineage were detected in the bone marrow cytology. Abdominal ultrasound showed thickening of intestinal loops. Considering the clinical and laboratory findings, the diagnosis of IHES was defined. Prednisolone treatment was instituted. The recurrence of peripheral eosinophilia occurred on the 35th day after therapy initiation. At that time, we opted to suspend the use of prednisolone and indicate the administration of deflazacort. With follow-up, therapeutic success with deflazacort was demonstrated, promoting the complete regression of clinical and ultrasound signs. The last glucocorticoid was maintained, but with a gradual dose reduction. The recognition of clinical and laboratory manifestations related to canine IHES is essential to establish an adequate diagnosis and therapy. Deflazacort emerges as a promising drug for controlling this disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical, laboratory and therapeutic aspects of canine idiopathic hypereosinophilic syndrome: case report

Silva¹,

Ferreira²,

Fernandes³

et al. 2018

AVB

View full text Add to dashboard Cite

show abstract

“…Of the reported cases, more than half have been Rottweilers (AROCH et al, 2001;DROUOT et al, 2007;FIGHERA et al, 2004;JAMES;MANSFIELD, 2009;JENSEN;NIELSEN, 1992;NDIKUWERA et al, 1992;PERKINS;WATSON, 2001;SYKES et al, 2001). The Rottweiler is a breed that has a high frequency of eosinophilic disorders.…”

Section: Discussionmentioning

confidence: 99%

“…Any organ can undergo infiltration and subsequent tissue damage by eosinophils with the lung, spleen, liver, lymph nodes, bone marrow, and gastrointestinal tract most commonly affected. As a result the clinical signs of the disease are extremely varied (FIGHERA et al, 2004;PERKINS;WATSON, 2001;SYKES et al, 2001). Rottweilers appear predisposed to the development of eosinophilic disorders, such as eosinophilic meningoencephalitis and HES (BENNET et al, 1997;LILLIEHÖÖK et al, 2000;NDIKUWERA et al, 1992;SYKES et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Idiopathic hypereosinophilic syndrome in a rottweiler: a case report

Ferian

Bach

Salbego

et al. 2017

SCA

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Eosinophils are cells of the immune system that have several important functions including phagocytosis of microorganisms, antigen presentation, contribution to chronic inflammation, and immunity against parasites. The hypereosinophilic syndrome (HES) is a rare disease in humans that is characterized by persistent eosinophilia (over six months) and variable eosinophil infiltration in organs such as the lungs, spleen, liver, lymph nodes, bone marrow, and gastrointestinal tract. Once in the tissues, these cells can cause damage by various mechanisms such as release of cytotoxic oxygen free radical and proteins. No etiology has yet been established for HES. The clinical signs vary and relate to the organs involved. In veterinary medicine, the disease has been described in cats, but rarely in dogs, with Rottweilers apparently more predisposed to developing the disease. Owing to the small number of cases reported in the veterinary literature, the prognosis of this disease and the most appropriate treatment options are unclear. Although it can be fatal in animals showing severe clinical symptoms, spontaneous remission may also occur. This study reports a case of HES in a Rottweiler in which the predominant clinical sign was abdominal effusion. We discuss the clinical and laboratory aspects of the disease. Key words: Abdominal effusion. Dog. Eosinophils. ResumoOs eosinófilos são células do sistema imunológico que tem importantes funções, tais como fagocitose de micro-organismos, apresentação de antígenos, contribuição para a cronicidade do processo inflamatório e imunidade contra parasitas. A síndrome hipereosinofílica (SHE) é uma enfermidade rara que acomete seres humanos, caracterizada por eosinofilia periférica persistente (acima de seis meses) e infiltração variável de eosinófilos em diferentes órgãos, como pulmão, baço, fígado, linfonodos, medula óssea e o trato gastrointestinal. Uma vez nos tecidos, essas células causam danos por diversos mecanismos, como liberação de proteínas citotóxicas e radicais livres de oxigênio. Não é possível identificar uma etiologia nos casos de SHE. Os sinais clínicos são variáveis, e diretamente relacionados com os órgãos acometidos. Em medicina veterinária, a moléstia já foi descrita em felinos, mas raramente em cães, sendo que animais da raça Rottweiler são mais predispostos ao desenvolvimento da doença. Em função do pequeno número de casos descritos na literatura veterinária, a evolução da doença e as opções mais apropriadas de tratamento são pouco conhecidas. Embora alguns animais apresentem sinais clínicos graves, podendo evoluir para o óbito, a remissão espontânea também pode ocorrer. O presente trabalho tem por objetivo relatar um caso de SHE com sinal clínico predominante de efusão abdominal em um filhote de cão da raça Rottweiler, abordando aspectos clínicos e laboratoriais da enfermidade. Palavras-chave: Cão. Efusão abdominal. Eosinófilos.

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Síndrome hipereosinofílica idiopática associada à doença eosinofílica disseminada em um cão

Cited by 2 publications

References 7 publications

Clinical, laboratory and therapeutic aspects of canine idiopathic hypereosinophilic syndrome: case report

Clinical, laboratory and therapeutic aspects of canine idiopathic hypereosinophilic syndrome: case report

Idiopathic hypereosinophilic syndrome in a rottweiler: a case report

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