Neoplasias mamárias em cadelas: influência hormonal e efeitos da ovario-histerectomia como terapia adjuvante

Fonseca, Cláudia Sampaio; Daleck, Carlos Roberto

doi:10.1590/s0103-84782000000400030

Cited by 41 publications

(55 citation statements)

References 12 publications

(11 reference statements)

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“…The mean of age was 9.3 years old, whose bitches were not castrated, four of them had at least one gestation and two received an injectable contraceptive. Based on this, it is possible to emphasize that these factors contribute to a greater risk of development of breast tumor in old bitches, not castrated and before or after puberty, as well as the use of contraceptives based on progesterone and estrogen [12,24].…”

Section: Discussionmentioning

confidence: 99%

CD4+, CD8+, FoxP3+ and HSP60+ Expressions in Cellular Infiltrate of Canine Mammary Carcinoma in Mixed Tumor

Lopes-Neto

Souza

Bouty

et al. 2017

Acta Scientiae. Vet.

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Background: Cancer is a complex process that receive many influences of the tumor microenvironment. The participation of immune system cells and proteins in tumor microenvironment is not yet completely understood. Thus, the aim of this study was to evaluate the infiltrate cellular, subpopulations of T-lymphocytes and HSP60 of canine mammary carcinoma in mixed tumor (CMCMT). Materials, Methods & Results:Female dogs (n = 20) were selected after Canine mammary tumor (CMT) diagnosis and data were achieved throughout clinical-pathological information. Clinical staging was evaluated and tumor biopsies were processed by histology and cellular infiltrate was performed according criteria and grade. Survival curve were generated by Kaplan-Meier and the lymphocytic infiltrate were compared by Log-Rank followed Chi-Square χ². For immunolabeling it was used anti-CD4, anti-CD8, anti-FoxP3 and HSP60 monoclonal antibodies and were attributed scores from 0 to 3. Clinical-pathological relationship was analyzed using Spearman correlation. This study was approved by the Committee for Ethics in Research using Animals (CEUA-UECE), protocol 12247080-2. Our data showed a mean age of 9.3 years-old, the size of tumors presented more than 5 cm (50%), which were located in inguinal mammary glands (70%), and CMTs shows I (70%) and II (30%) grade. The cellular infiltrate was distributed both in peri and intratumoral regions, dispersed multifocally with moderate intensity and lymphocytes were the major populations found into tumors (n = 826 ± 220). In relationship to cellular infiltrate with CMT grade it was observed that lymphocytes (ρ = 0.28) and plasma cells (ρ = 0.22) showed a slight positive correlation, and an opposed negative correlation of neutrophils (ρ = -0.1) and macrophages (ρ = -0.38). CMT presents moderate lymphocytic infiltrate (< 800 lymphocytes), shows higher (P = 0.01) survival rates as compared to intense lymphocytic infiltrate (≥ 800 lymphocytes). FoxP3+ showed lower intensity while CD4+ and CD8+ expression were concentrated surrounding of lymphocytic infiltrate tumor region. HSP60+ was observed in the inflammatory and tumor cells. Discussion: Our data are according to a greater risk to the development of breast tumor in old bitches, not castrated and before or after puberty, as well as the use of contraceptives based on progesterone and estrogen. In relation to size of tumor, these findings reinforce that there is a relationship of tumor size with a higher malignancy grade and with a worse prognosis. The predominant tumor location was in the inguinal breasts that is attributed to the high activity of the mammary glands to hormonal stimuli. CMT with low clinical staging are associated with greater overall survival of affected bitches. In relation to tumor microenvironment, it has been reported that heterogeneous populations of the immune system cells often infiltrate the mammary tumors, whose lymphocytes are the main cells. It is suggested that tumor lymphocytosis may be necessary for malignant behavior of the tumo...

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Section: Discussionmentioning

confidence: 99%

CD4+, CD8+, FoxP3+ and HSP60+ Expressions in Cellular Infiltrate of Canine Mammary Carcinoma in Mixed Tumor

Lopes-Neto

Souza

Bouty

et al. 2017

Acta Scientiae. Vet.

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“…As cadelas submetidas ao procedimento após os dois anos e seis meses de idade não são beneficiadas pelo efeito profilático dele (Morrison, 1998;Zuccari et al, 2001;Green et al, 2009 Os mastocitomas são as neoplasias dos mastócitos, os quais têm origem na medula óssea e no tecido conjuntivo. Podem se localizar em qualquer tecido, mas são mais frequentes na pele, representando de 7,0% a 21,0% de todos os tumores de pele e 11,0% a 27,0% das neoplasias malignas em cães (Fox, 1998 O hemangiossarcoma (HSA) é uma neoplasia maligna de origem endotelial vascular, que pode estar localizado no baço, fígado, coração, pele, pulmões, rins, músculos, ossos, bexiga urinária e peritônio . Acomete principalmente cães com idade variando entre oito e 13 anos e ocorre, majoritariamente, em raças de grande porte, como o Pastor Alemão, Labrador Retriever, Golden Retriever e Italian Greyhound (Schulteiss, 2004).…”

Section: Introductionunclassified

Prevalência de neoplasias diagnosticadas em cães no Hospital Veterinário da Universidade Eduardo Mondlane, Moçambique

Santos

Cardoso

Oliveira³

et al. 2013

Arq. Bras. Med. Vet. Zootec.

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“…A glândula mamária é o local mais comumente afetado por neoplasias em fêmeas caninas sendo que estas representam 50% de todos os tumores nesta espécie 1,2,3,4,5,6,7,8 . Além disso, atualmente surgiu um especial interesse no estudo dos tumores das glândulas mamárias em cadelas devido à sua semelhança com o câncer de mama em mulheres 3,9,10 .…”

Section: Introductionunclassified

Avaliação da caspase-3 e Ki-67 como marcadores prognósticos nas neoplasias mamárias em cadelas

Terzian

Zuccari

Pereira

et al. 2007

Braz. J. Vet. Res. Anim. Sci.

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A apoptose e a proliferação celular possuem uma participação importante na tumorigênese, determinando o crescimento tumoral e consequentemente sua agressividade. O presente estudo teve como objetivo avaliar a ocorrência da apoptose associada a proliferação celular em neoplasias mamárias em cadelas e a elas a evolução clínica do paciente. Setenta animais foram submetidos à exérese cirúrgica do tumor, sendo este submetido ao diagnóstico histopatológico e marcação imuno-histoquímica para caspase-3 e Ki-67. Estes marcadores de apoptose e proliferação celular demonstraram grande expressão nas neoplasias malignas, principalmente nos carcinomas, considerado o mais maligno dos tumores. Estes resultados corroboram os dados da literatura e contribuem para um prognóstico tumoral criterioso que complementa a classificação tumoral existente proporcionando uma melhor e maior sobrevida devido a uma adequação do procedimento terapêutico de cada paciente.

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Neoplasias mamárias em cadelas: influência hormonal e efeitos da ovario-histerectomia como terapia adjuvante

Cited by 41 publications

References 12 publications

CD4+, CD8+, FoxP3+ and HSP60+ Expressions in Cellular Infiltrate of Canine Mammary Carcinoma in Mixed Tumor

CD4+, CD8+, FoxP3+ and HSP60+ Expressions in Cellular Infiltrate of Canine Mammary Carcinoma in Mixed Tumor

Prevalência de neoplasias diagnosticadas em cães no Hospital Veterinário da Universidade Eduardo Mondlane, Moçambique

Avaliação da caspase-3 e Ki-67 como marcadores prognósticos nas neoplasias mamárias em cadelas

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