Serotonin transporter gene polymorphisms: a case-control study

Abstract

<jats:p>Considerable evidence indicates that serotonergic mechanisms, particularly the serotonin transporter, are involved in alcoholism and tobacco use and are influenced by polymorphism of the promoter region of 5HTT (5-HTTLPR). As alcohol and tobacco consumption have been implicated in the pathogenesis of oral cancer, the purpose of this study was to investigate 5-HTTLPR polymorphism in patients with oral squamous cell carcinoma (OSCC) compared with a control group in a sample of Brazilian patients. One hundred and three patients affected by OSCC and 103 volunteers without OSCC were genotyped for 5-HTTLPR. Both groups were matched for age, sex and tobacco use. The chi-squared test was used for statistical analysis (α=0.05). There was no statistically significant difference in 5-HTTLPR genotypes between case and control group (p= 0.408). In conclusion, the present investigation demonstrated that serotonin transporter polymorphisms are not implicated in the OSSC development.</jats:p>

Association between serotonin transporter gene polymorphism and recurrent aphthous stomatitis

“…Furthermore, the study conducted to determine the association between serotonin transporter gene polymorphism in patients of oral squamous cell carcinoma owing to an increase consumption of tobacco and alcohol in the same ethnic population failed to show any statistically signification correlation. [ 19 ]…”

Polimorfismos genéticos e o câncer de cavidade oral e laringe: contribuição do álcool e fumo

“…A serotonina (5- (Thompson et al, 2000;Matsushita et al, 2001;Herman et al, 2003;van der Zwaluw et al, 2010), enquanto outros não encontraram essa associação (Hopfer et al, 2005;Gacek et al, 2008). Em uma amostra brasileira, Abdo et al (2012) Stephens et al, 2013). A presença do alelo polimórfico A (Asn) tem sido relacionada ao uso precoce, a sensação prazerosa e maior consumo do tabaco e também um risco maior de câncer da cavidade oral e laringe (Lips et al, 2010;Chen et al, 2011;Fowler;Kenny, 2014).…”

Eficácia da ondansetrona no tratamento de dependentes de álcool

“…Assim, somente os alcoolistas com constituição alélica específica para o gene transportador de serotonina (5-HTT) têm sido beneficiados com o sucesso no tratamento com ondansetrona, independente da idade de início dos problemas com o uso do álcool. Alguns estudos realizados em nossa população têm mostrado uma frequência baixa do alelo S, e a ocorrência do genótipo SS foi encontrada em 21,4% da população (Abdo et al 2012;Meira-Lima et al, 2005;Mendes de Oliveira et al, 1998). Essas taxas tão pequenas se devem à alta miscigenação de raças presente no Brasil (Parra et al, 2003 (Rubio et al, 2005).…”